A5002946409- Cancer-related molecular mechanisms research
- Endometrial and Cervical Cancer Treatments
- Circular RNAs in diseases
- Cancer, Stress, Anesthesia, and Immune Response
- RNA modifications and cancer
- Estrogen and related hormone effects
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Chromosomal and Genetic Variations
- Catalytic C–H Functionalization Methods
- Genetic diversity and population structure
- Synthesis and Catalytic Reactions
- RNA Interference and Gene Delivery
- Genomics and Chromatin Dynamics
- Regulation of Appetite and Obesity
- Catalytic Cross-Coupling Reactions
- Adipose Tissue and Metabolism
- Immune cells in cancer
- Extracellular vesicles in disease
- Heat shock proteins research
- Medicinal Plants and Bioactive Compounds
- Digestive system and related health
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Advanced Nanomaterials in Catalysis
- Neurofibromatosis and Schwannoma Cases
Ruijin Hospital
2024
Shanghai Jiao Tong University
2019-2024
Union Hospital
2019-2024
Jilin University
2016-2024
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2024
Zhengzhou University
2017-2023
International Peace Maternity & Child Health Hospital
2019-2022
Shanghai Municipal People's Government
2021-2022
Northwest University
2022
Union Hospital
2016-2019
STAT3 is a ubiquitous transcription factor that indispensable during early embryogenesis. To study the functions of postnatally, we generated conditional STAT3-deficient mice. end, STAT3lox/lox mice were crossed with expressing Cre under control rat insulin II gene promoter (RIP-Cre mice). Immunohistochemical and Western blot analyses showed deleted from β cells in islets Langerhans. Genomic DNA PCR revealed deletion also occurred hypothalamus. Hypothalamic expression was further confirmed...
Perineural invasion (PNI) has guiding significances for nerve preservation in cervical cancer, but there is no definite marker indicating PNI. Two cancer cell lines (HeLa and ME-180) showed significant abilities to migrate along neurites vitro vivo. Morphological observation revealed that Schwann cells (SC) arrived at the sites of before onset metastasis. We used high-throughput antibody array screen signals mediating interaction found high expression CCL2 dorsal root ganglion (DRG)....
Soluble leptin receptor (OBRe), one of several isoforms, is the only bona fide binding protein in plasma. Our earlier studies demonstrated that OBRe modulates levels circulation. Both clinical and vitro have shown expression inversely correlated to body weight levels. However, it not clear whether plays an active role, either collaboration with or independently, maintenance weight.To investigate function regulation energy homeostasis, we generated transgenic mice express under control human...
Abstract Background Emerging evidence demonstrates that lncRNAs play pivotal roles in tumor energy metabolism; however, the detailed mechanisms of regulation glycolysis remain largely unknown. Methods The expression SLC2A1-AS1 was investigated by TCGA, GEO dataset and qRT-PCR. binding GLI3 to promoter detected Luciferase Reporter Assay System Ago2-RIP assay. FISH performed determine localization ESCC cells. Double Report assay used investigate interaction miR-378a-3p with Glut1....
Iron-based nanomaterials have recently been developed as excellent and potent Fenton reagents to reactive oxygen species (ROS) during chemodynamic therapy (CDT). The performance of the materials, however, can be impaired by intrinsic antioxidant defense mechanism in organisms, such autophagy.The nanoscale metal-organic frameworks (nMOFs), nMIL-100 (Fe), were exploited characterized. Also, Fenton-like catalytic characteristics, anti-endometrial cancer (EC) effects potential mechanisms (Fe)...
Abstract Background Swainsonine is a natural indolizidine alkaloid, its anti-tumor activity has been widely reported in varied cancers. This study aimed to investigate whether exerted impact on glioma cells, likewise uncovered the relative molecular mechanisms. Methods After administration with diverse concentrations of Swainsonine, cell growth, migration and invasion U251 LN444 cells were appraised by common-used CCK-8, BrdU, flow cytometry Transwell assays. MiR-92a mimic, inhibitor...
The incidence of endometrial cancer (EC) is intensively increasing. However, due to the complexity and heterogeneity EC, molecular targeted therapy still limited. reliable accurate biomarkers for tumor progression are urgently demanded. After normalizing data from Gene Expression Omnibus (GEO) Cancer Genome Atlas (TCGA), we utilized limma WGCNA packages identify differentially expressed genes (DEGs). copy number variations candidate were investigated by cBioPortal. Enrichment pathways...
Medroxyprogesterone acetate (MPA) is the main conservative treatment for endometrial cancer (EC) patients desirable to preserve fertility and those who cannot suffer from surgery. Considering high incidence of progestin resistance recurrence MPA treatment, we reproposed antipsychotics chlorpromazine (CPZ) as a new strategy both progestin-sensitive -resistant cancer. Cytobiology experiments indicated that CPZ could significantly suppress proliferation, migration/invasion induce apoptosis in...
Germ cell-specific genes are active in oocytes and spermatocytes but silent all other cell types. To understand the basis for this seemingly simple pattern of regulation, we characterized factors that recognize promoter-proximal region germ TFIIAα/β-like factor (ALF) gene. Two protein-DNA complexes formed with liver extracts (C4 C5) due to zinc finger proteins Sp1 Sp3, respectively, whereas another complex (C6) is transcription RFX1. additional (C1 C3) multivalent protein CTCF, a plays role...
Progestin resistance is a critical obstacle for endometrial conservative therapy. Therefore, studies to acquire more comprehensive understanding of the mechanisms are urgent. However, pivotal molecules still unexplored.We downloaded GSE121367 from GEO database. The "limma" R language package was applied identify differentially expressed genes (DEGs). We conducted Gene Set Enrichment Analysis (GSEA) and Variation (GSVA). Protein-protein interaction constructed by STRING visualized in...
Abstract The development of simplified synthetic strategy to create structurally and functionally diverse pseudo‐natural macrocyclic molecules is highly appealing but poses a marked challenge. Inspired by natural scaffolds, herein, we describe practical concise ligand‐enabled Pd(II)‐catalyzed sp 3 C−H alkylation, olefination arylation macrocyclization, which could offer novel set sulfonamides. Interestingly, the potential ligand acceleration in activation also demonstrated an unprecedented...
Perineural invasion (PNI) is the neoplastic of nerves by cancer cells, a process that may prove to be another metastatic route besides direct invasion, lymphatic spread, and vascular dissemination. Given increasing incidence association with poor prognosis, revealing pathogenesis perineural great importance.Four datasets related PNI were downloaded from Gene Expression Omnibus database used construct weighted gene co-expression network analysis (WGCNA). The intersection potential pathways...
Abstract The development of simplified synthetic strategy to create structurally and functionally diverse pseudo‐natural macrocyclic molecules is highly appealing but poses a marked challenge. Inspired by natural scaffolds, herein, we describe practical concise ligand‐enabled Pd(II)‐catalyzed sp 3 C−H alkylation, olefination arylation macrocyclization, which could offer novel set sulfonamides. Interestingly, the potential ligand acceleration in activation also demonstrated an unprecedented...
Polyploids are cells or organisms with a genome consisting of more than two sets homologous chromosomes. Polyploid plants have important traits that facilitate speciation and thus often model systems for evolutionary, molecular ecology agricultural studies. However, due to their unusual mode inheritance double-reduction, diploid models population genetic analysis cannot properly be applied autopolyploids. To overcome this problem, we developed software package entitled vcfpop perform variety...