A5102890010- Cancer-related molecular mechanisms research
- Gynecological conditions and treatments
- Cell Adhesion Molecules Research
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Cervical Cancer and HPV Research
- Wnt/β-catenin signaling in development and cancer
- Caveolin-1 and cellular processes
- Metabolism, Diabetes, and Cancer
- Epigenetics and DNA Methylation
- Liver physiology and pathology
- Genital Health and Disease
- Endometrial and Cervical Cancer Treatments
- Cardiovascular Disease and Adiposity
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Urinary Bladder and Prostate Research
- Uterine Myomas and Treatments
- PARP inhibition in cancer therapy
- Nanoplatforms for cancer theranostics
- Heme Oxygenase-1 and Carbon Monoxide
- Diphtheria, Corynebacterium, and Tetanus
- Ovarian cancer diagnosis and treatment
- Molecular Biology Techniques and Applications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Shanghai East Hospital
2019-2024
Tongji University
2021
Second Military Medical University
2009-2014
Shanghai Pudong New Area Gongli Hospital
2009-2014
MicroRNA-138 (miR-138) acts as a key regulator in the modulation of carcinogenesis numerous tumor types. Chemoresistance is common and relevant to failure multiple treatment strategies for cervical cancer. However, biological role miR-138 progression chemosensitivity cancer still unclear. The present study aimed investigate expression, function mechanism An mimic, inhibitor negative control were transfected into SiHa C33A cells. expression its target assessed by reverse transcription-PCR,...
Mounting evidence has highlighted the immune environment as a critical feature in development of cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC). However, relationship between clinical characteristics CESC remain unclear. Therefore, aim this study was to further characterize tumor microenvironment features using variety bioinformatic methods. Expression profiles (303 CESCs three control samples) relevant data were obtained from The Cancer Genome Atlas. We divided...
Alkaline-encrusted cystitis (AEC) has been reported sporadically during the past 90 years. It occurs mainly in immunocompromised or debilitated patients after urologic procedures. However, we report two unexpected cases of AEC who were young and not under conditions transplantation, immunocompromise debilitation. Both had undergone a ureteroscopic lithotripsy procedure before being diagnosed as having encrusted cystitis. Although no information on such atypical is available, at least to our...
Background: Caveolin-1 (Cav-1) is known to regulate angiogenesis. However, little about Cav-1’s role in polycystic ovary syndrome (PCOS). This study aims investigate expression the endometrium of PCOS rats during implantation window and its association with endometrial Methods: Female Sprague Dawley (SD) were randomly divided into control groups. The group mated after ovulation induction, while estrus period. On 2nd 5th days pregnancy, sacrificed, was isolated from their uteruses....
Abstract Primary leiomyosarcoma of the fallopian tube (PLFT) is an extremely rare gynecological malignancy that has only been described in case reports. Fertility‐sparing treatment for PLFT not reported previously. A 24‐year‐old nulligravida woman was diagnosed with stage IC1 right after experiencing lower quadrant pain 2 weeks. She underwent laparoscopic salpingectomy to preserve fertility followed by adjuvant chemotherapy gemcitabine/docetaxel. subsequently became pregnant spontaneously,...
Objective. To evaluate the efficacy and safety of Yushen Tongluo Granule (YSTLG) combined with clomiphene citrate (CC) in treatment anovulatory infertility. Methods. This randomized, double-blinded, placebo-controlled clinical trial was carried out Department Obstetrics Gynecology Traditional Chinese Medicine (TCM). During 3 menstrual cycle intervention periods, all subjects received 50 mg/day CC from day 5 until 9 menstruation. If no ovulation, amount per increased 150 mg/day. Participants...
Abstract Backgroud Endometrial Carcinoma (EC) is the most common gynecological malignancy among women. Even with a favorable prognosis, cure still elusive recurrence, chemotherapy resistance and poor outcome. Poly ADP-ribose polymerase inhibitors (PARPi) have been emerged as promising cancer therapeutics, especially for tumors deficient homologous recombination (HR) repair. Niraparib example well established ovarian cancer. Metformin, an antidiabetic drug, has reported to be new adjunctive...
Evidence highlighted the immune environment as a critical feature in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC). The aim of this study was to characterize relationship between CESC microenvironment. Expression profiles (303 CESCs) clinical data were obtained from Cancer Genome Atlas (TCGA). We divided cases into subtypes performed differential gene expression analysis. Gene Ontology (GO) set enrichment analysis (GSEA) identify potential molecular mechanisms. Data...