Keng Shen

ORCID: 0000-0003-2867-590X
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About
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Research Areas
  • Endometrial and Cervical Cancer Treatments
  • Cervical Cancer and HPV Research
  • Ovarian cancer diagnosis and treatment
  • Uterine Myomas and Treatments
  • Endometriosis Research and Treatment
  • Gynecological conditions and treatments
  • Estrogen and related hormone effects
  • Sarcoma Diagnosis and Treatment
  • Cancer Diagnosis and Treatment
  • Testicular diseases and treatments
  • Management of metastatic bone disease
  • Cancer Risks and Factors
  • Gestational Trophoblastic Disease Studies
  • Cancer survivorship and care
  • Ovarian function and disorders
  • Laser-induced spectroscopy and plasma
  • Vascular Anomalies and Treatments
  • Intestinal and Peritoneal Adhesions
  • Sperm and Testicular Function
  • Machine Learning in Materials Science
  • HER2/EGFR in Cancer Research
  • Urologic and reproductive health conditions
  • Hernia repair and management
  • Peptidase Inhibition and Analysis
  • Ethics in Clinical Research

Peking Union Medical College Hospital
2013-2024

Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024

South China Normal University
2024

Academia Sinica
2022

National Clinical Research Center for Digestive Diseases
2021

There are limited data comparing the prognosis and fertility outcomes of patients with early cervical cancer treated by trans-vaginal radical trachelectomy (VRT) or abdominal (ART).The objective this study was to compare surgical pathologic characteristics, VRT ART. Matched-case based on a prospectively maintained database underwent in 10 centres China designed Totally 150 cases, 77 73 ART group, were included. provide similar pathological except larger specimens obtained In no patient...

10.1038/bjc.2013.656 article EN cc-by-nc-sa British Journal of Cancer 2013-10-29

Study Objective: To compare the surgical and oncologic outcomes between open abdomen radical hysterectomy (ARH) laparoscopic (LRH) for cervical cancer. methods: Retrospective observational study with propensity score matching was used to ensure balanced groups ARH LRH. One hundred ninety-eight women cancer, 99 treated using LRH, January 2012 December 2014. Outcomes included disease-free survival (DFS), overall (OS), intra-operative factors, post-operator recovery, urinary retention, adverse...

10.3389/fonc.2019.01107 article EN cc-by Frontiers in Oncology 2019-10-30

To evaluate the efficacy and prognosis of fertility-sparing treatment on endometrial cancer (EC) atypical hyperplasia (AEH) patients with BMI ≥ 30 kg/m2.A total 102 EC or AEH obesity who received fertility-preserving therapy in Department Obstetrics Gynecology, Peking Union Medical College Hospital were included our study. All followed up regularly. Clinical characteristics, outcomes, adverse events, reproductive outcomes collected analyzed.A 88 (86.3%) achieved complete response (CR), 92.5%...

10.3389/fonc.2022.812346 article EN cc-by Frontiers in Oncology 2022-02-18

Objective: The objective of this study was to establish a program model for use in wide-spread cervical cancer screening. :Methods: Cervical screening conducted Zhongshan city Guangdong province, China through coordinated network multiple institutes and hospitals. A total 43,567 women, 35 59 years age, were screened during regular gynecological examinations using the liquid-based ThinPrep cytology test (TCT). Patients who tested positive recalled further treatment. Results: TCT-positive rate...

10.7314/apjcp.2014.15.2.671 article EN cc-by Asian Pacific Journal of Cancer Prevention 2014-01-30

Objective: To explore appropriate treatment modality of microinvasive cervical cancer (MIC) and to analyze prognosis risk factors recurrence.Methods: A cohort 324 Chinese patients with MIC diagnosed treated at Peking Union Medical College Hospital was retrospectively reviewed.Demographic features, modalities, pathologic parameters, residual disease, survival recurrence were analyzed.Results: Of all patients, 280 cases staged IA1 44 IA2 MIC.Twenty-five (7.7%) found have lympho-vascular space...

10.3802/jgo.2014.25.4.293 article EN cc-by-nc Journal of Gynecologic Oncology 2014-01-01

Objective: To compare patient survival outcomes between completion hysterectomy and conventional surveillance in locally advanced adenocarcinoma of the cervix after concurrent chemoradiotherapy (CCRT).Methods: Patients with CCRT were identified a tertiary academic center database from 2004 to 2018.Patients received or CCRT.We compared progression-free (PFS) overall (OS) patients without adjuvant hysterectomy.Surgery features, operative complications, pathologic characteristics...

10.3802/jgo.2020.31.e16 article EN cc-by-nc Journal of Gynecologic Oncology 2019-09-24

Fertility-sparing surgery was optimal to patients with tumor diameter smaller than 2 cm. For larger tumors, neoadjuvant chemotherapy can debulk the and offer chance of surgery. We report cases stage IB1 cervical cancer treated by fertility-sparing Relevant literature reviewed. Its safety, efficacy, reproductive outcome need be validated in future.

10.3802/jgo.2013.24.3.287 article EN cc-by-nc Journal of Gynecologic Oncology 2013-01-01

To evaluate the efficacy and prognosis of fertility-sparing re-treatment on patients with recurrent endometrial cancer (EC) atypical hyperplasia (AEH) who wish to preserve their uterus after complete remission (CR) for primary conservative therapy.We performed a retrospective study EC or AEH received achieving CR. Data regarding clinicopathological factors, adverse events, treatment efficacy, tumor prognosis, reproductive outcome were analyzed.Of 98 median disease-free interval period 19...

10.3389/fonc.2021.738370 article EN cc-by Frontiers in Oncology 2021-09-09

Abstract Purpose This study investigated the clinicopathological features and surgical procedures of adnexal masses with abdominal pain in pediatric adolescent patients. Our objective was to better define clinical presentation torsion distinguish characteristics those an alternate diagnosis. Methods Retrospective cohort 212 patients performed who admitted for presenting mass between March 2012 December 2019.Medical records were reviewed age at operation, including symptoms signs; levels...

10.1186/s13023-024-03101-4 article EN cc-by Orphanet Journal of Rare Diseases 2024-03-21

This study aimed to identify the clinical and pathological characteristics possible prognostic factors for Chinese patients with early-stage ovarian endometrioid carcinoma. The present reviewed medical records of who received initial treatment a postoperative diagnosis carcinoma at our center. In all, 78 had stage I this series, 5-year overall survival rate disease-free (DFS) rates was 98.7% 87.2%, respectively. Univariate analysis showed that influence DFS include menopausal status, FIGO...

10.1186/s13048-017-0361-0 article EN cc-by Journal of Ovarian Research 2017-09-18

Introduction: With the expansion of value-based medicine, we explore whether using type III hysterectomy to treat low-risk, early-stage cervical cancer constitutes overtreatment. In present study, evaluate midterm safety and postoperative quality life patients who underwent II versus with systematic lymphadenectomy for low-risk (International Federation Gynecology Obstetrics (FIGO) IA2-IB1; maximum tumor diameter ˂2 cm). Patients methods: The main study was a multicenter, phase III,...

10.3389/fonc.2018.00568 article EN cc-by Frontiers in Oncology 2018-11-28

Objective To evaluate the efficacy and safety of gonadotropin-releasing hormone agonist (GnRHa) combined with a levonorgestrel-releasing intrauterine device (LNG-IUD) or aromatase inhibitor (letrozole) in women endometrial carcinoma atypical hyperplasia who wished to preserve fertility. Methods Patients at Department Obstetrics Gynecology, Peking Union Medical College Hospital between January 2013 December 2020 were retrospectively reviewed. A total 179 patients unsuitable undergo treatment...

10.1136/ijgc-2022-003882 article EN cc-by International Journal of Gynecological Cancer 2022-11-11
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