A5023287585- Yersinia bacterium, plague, ectoparasites research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Vibrio bacteria research studies
- Immunotherapy and Immune Responses
- Galectins and Cancer Biology
- Vector-borne infectious diseases
- Plant-based Medicinal Research
- Bacillus and Francisella bacterial research
- Monoclonal and Polyclonal Antibodies Research
- Pharmacological Effects of Natural Compounds
- Helicobacter pylori-related gastroenterology studies
- Mycobacterium research and diagnosis
University of California, Santa Cruz
2021-2024
Stanford University
2021-2024
The response of gamma delta (γδ) T cells in the acute versus chronic phases same infection is unclear. How γδ function Mycobacterium tuberculosis (Mtb) well characterized, but their during persistent Mtb not understood, even though most infections with manifest as a chronic, clinically asymptomatic state. Here, we analyze peripheral blood from South African adolescent cohort and show that unique CD8 + cell subset features “memory inflation” expands infection. These are hyporesponsive to...
γδ T cells are essential for immune defense and modulating physiological processes. While they have the potential to recognize large numbers of antigens through somatic gene rearrangement, which trigger most cell response remain unidentified, role antigen recognition in function is contentious. Here, we show that some receptors (TCRs) exhibit polyspecificity, recognizing multiple ligands diverse molecular nature. These include haptens, metabolites, neurotransmitters, posttranslational...
ABSTRACT Helicobacter pylori infects roughly half the world’s population, causing gastritis, peptic ulcers, and gastric cancer in a subset. These pathologies occur response to chronic inflammatory state, but it is not fully understood how H. controls this process. We characterized of mutants that cannot produce quorum sensing molecule autoinducer 2 (AI-2) by deleting gene for AI-2 synthase, luxS . Our work shows colonize stomach normally recruit high numbers CD4 + T cells during infection....
The type III secretion system (T3SS) is an appendage used by many bacterial pathogens, such as pathogenic Yersinia , to subvert host defenses. However, because the T3SS energetically costly and immunogenic, it must be tightly regulated in response environmental cues enable survival host. Here we show that expression of Ysc master regulator, LcrF, orchestrated opposing activities repressive H-NS/YmoA histone-like protein complex induction iron oxygen-regulated IscR transcription factor. While...
A key virulence mechanism for many Gram-negative pathogens is the type III secretion system (T3SS), a needle-like appendage that translocates cytotoxic or immunomodulatory effector proteins into host cells. The T3SS target antimicrobial discovery campaigns since it accessible extracellularly and largely absent from non-pathogenic bacteria. Recent studies demonstrated of Yersinia Salmonella are regulated by factors responsive to iron oxygen, which important niche-specific signals encountered...
Summary γδ T cells contribute to host immune defense uniquely; but how they function in different stages (e.g., acute versus chronic) of a specific infection remains unclear. As the role early, active Mycobacterium tuberculosis (Mtb) is well documented, we focused on elucidating cell response persistent or controlled Mtb infection. Systems analysis circulating from South African adolescent cohort identified distinct population CD8+ that expanded this state. These had features indicative...
Abstract The type III secretion system (T3SS) is a appendage used by many bacterial pathogens, such as pathogenic Yersinia , to subvert host defenses. However, because the T3SS energetically costly and immunogenic, it must be tightly regulated in response environmental cues enable survival host. Here we show that expression of Ysc master regulator, LcrF, orchestrated opposing activities repressive YmoA/H-NS histone-like protein complex induction iron oxygen-regulated IscR transcription...