A5086694164- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Viral gastroenteritis research and epidemiology
- Congenital Diaphragmatic Hernia Studies
- Clinical Nutrition and Gastroenterology
- Respiratory viral infections research
- Pregnancy and preeclampsia studies
- Respiratory Support and Mechanisms
- Birth, Development, and Health
- Breastfeeding Practices and Influences
- Child Nutrition and Water Access
- Innovations in Medical Education
- Biochemical and Molecular Research
- Cerebrospinal fluid and hydrocephalus
- HIV/AIDS drug development and treatment
- Protein Hydrolysis and Bioactive Peptides
- Pediatric Hepatobiliary Diseases and Treatments
- Renal and related cancers
- Extracellular vesicles in disease
- Food Allergy and Anaphylaxis Research
- Congenital Heart Disease Studies
- Infant Development and Preterm Care
- HIV Research and Treatment
- Retinopathy of Prematurity Studies
- Bone Metabolism and Diseases
Oregon Health & Science University
2016-2025
Oregon National Primate Research Center
2023-2025
Doernbecher Children's Hospital
2021
RELX Group (United States)
2020
Stanford University
1997-2012
Santa Clara Valley Medical Center
2011-2012
Palo Alto University
2011
Howard Hughes Medical Institute
1995
University Medical Center
1995
To assess the effects of Bifidobacteriumlongum subsp. infantis EVC001 (Binfantis EVC001) administration on incidence necrotizing enterocolitis (NEC) in preterm infants a single level IV neonatal intensive care unit (NICU).Nonconcurrent retrospective analysis 2 cohorts very low birth weight (VLBW) not exposed and to Binfantis probiotic at Oregon Health & Science University from 2014 2020. Outcomes included NEC NEC-associated mortality, including subgroup extremely (ELBW) infants. Log-binomial...
Abstract Human milk contains extracellular vesicles (HMEVs). Pre‐clinical models suggest that HMEVs may enhance intestinal function and limit inflammation; however, it is unknown if or their cargo survive neonatal human digestion. This limits the ability to leverage HMEV as additives infant nutrition therapeutics. study aimed develop an EV isolation pipeline from small volumes of contents after feeding (digesta) address hypothesis in vivo digestion be taken up epithelial cells (IECs)....
ABSTRACT Prior to the introduction of novel food ingredients into supply, safety risk assessments are required, and numerous prediction models have been developed validated evaluate safety. The allergenic potential Helaina recombinant human lactoferrin (rhLF, Effera™), produced in Komagataella phaffii ( K. ) was assessed by literature search, bioinformatics sequence comparisons known allergens, glycan allergenicity assessment, a simulated pepsin digestion model. search identified no for...
Integrase catalyzes two essential steps in the integration of retroviral genome--end processing and strand transfer--both which require interaction integrase with viral att sites located at ends genomic DNA. These different polynucleotidyl transfer reactions are apparently carried out by a single active site. The end product these reactions, integrated provirus, does not undergo transposition remains stable part host cell genome. A central question understanding mechanism is how site...
For bioactive milk peptides to be relevant infant health, they must released by gastrointestinal proteolysis and resist further until reach their site of activity. The intestinal tract is the likeliest for most bioactivities, but it currently unknown whether are present therein. purpose study was identify antimicrobial bifidogenic in tract. Milk were extracted from samples, activities bulk peptide extracts determined measuring growth Escherichia coli, Staphylococcus aureus, Bifidobacterium...
Introduction Prior to the introduction of novel food ingredients into supply, safety risk assessments are required, and numerous prediction models have been developed validated evaluate safety. Methods The allergenic potential Helaina recombinant human lactoferrin (rhLF, Effera™), produced in Komagataella phaffii ( K. ) was assessed by literature search, bioinformatics sequence comparisons known allergens, glycan allergenicity assessment, a simulated pepsin digestion model. Results search...
Retroviral integration involves two DNA substrates that play different roles. The viral substrate is recognized by virtue of specific nucleotide sequences near the end a double-stranded molecule. target at internal sites with little sequence preference; nucleosomal appears to be preferred for this role. Despite apparent asymmetry in sequence, structure, and roles reaction, existence distinct binding has been controversial. In report, we describe expression Escherichia coli purification...
To prevent infectious diarrhea in infants, orally-supplemented enteric pathogen-specific recombinant antibodies would need to resist degradation the gastrointestinal tract. Palivizumab, a antibody specific respiratory syncytial virus (RSV), was used as model assess digestion of neutralizing infant digestion. The aim determine remaining binding activity RSV F protein-specific monoclonal and naturally-occurring immunoglobulins (Ig) different isoforms (IgG, IgA, sIgA) across an ex vivo...
Abstract Maternal malnutrition increases fetal and neonatal morbidity, partly by affecting placental function morphology, but its impact on hemodynamics are unknown. Our objective was to define the of maternal oxygen reserve perfusion in vivo a rhesus macaque model protein restriction (PR) using advanced imaging. Animals were fed control (CON, 26% protein), 33% PR diet (17% or 50% (13% protein, n = 8/group) preconception throughout pregnancy. underwent Doppler ultrasound biometry followed...
Abstract Amniotic fluid is a complex biological medium that offers protection to the fetus and plays key role in normal fetal nutrition, organogenesis, potentially programming. also critically involved longitudinally shaping utero milieu during pregnancy. Yet, molecular mechanism(s) of action by which amniotic regulates development ill-defined partly due an incomplete understanding evolving composition proteome. Prior research consisting cross-sectional studies suggests proteome changes as...
PurposeRetinopathy of Prematurity (ROP) is one the leading causes blindness in children. Although role oxygen pathophysiology ROP well established, a precise understanding dynamic relationship between exposure incidence and severity lacking. The purpose this study was to evaluate correlation time-dependent variables onset retinopathy premature (ROP).DesignRetrospective cohort studySubjectsTwo hundred thirty infants who were born at single academic center met inclusion criteria. Infants are...
Abstract Objective This study evaluates the effectiveness of a novel device, LifeBubble, in reducing umbilical cord catheter (UC) migration and associated complications neonates. Study design A retrospective review was performed at Oregon Health & Science University’s NICU (2019–2021) to compare standard adhesive securement with LifeBubble. The primary outcomes were UC migration, discontinuation due malposition, CLABSI incidence. Differences between groups statistically analyzed logistic...
Oral administration of engineered immunoglobulins has the potential to prevent enteric pathogen-induced diarrhea in infants. To infection, these antibodies need survive functionally intact proteolytic environment gastrointestinal tract. This research examined both ex vivo and functional survival across infant digestion palivizumab, a model FDA-approved recombinant antibody against respiratory syncytial virus (RSV) F protein. Palivizumab-fortified feed (formula or human milk), gastric...
Pulmonary interstitial emphysema (PIE) is a familiar complication of mechanical ventilation in premature infants. Its most severe form, marked by life-threatening respiratory and cardiovascular compromise, particularly vexing problem neonatology. Treatment modalities rely on decubitus positioning reduction mean airway pressure, but refractory PIE unresponsive to these maneuvers. Other options such as selective unilateral bronchial intubation, balloon catheter occlusion, lung volume...