A5067551418- Folate and B Vitamins Research
- Metabolism and Genetic Disorders
- Esophageal and GI Pathology
- Birth, Development, and Health
- Iron Metabolism and Disorders
- Pregnancy and preeclampsia studies
- Porphyrin Metabolism and Disorders
- Diet and metabolism studies
- Fluoride Effects and Removal
- Gestational Diabetes Research and Management
- Epigenetics and DNA Methylation
- Nutritional Studies and Diet
- Alcoholism and Thiamine Deficiency
- Vitamin D Research Studies
- HIV-related health complications and treatments
- Pharmacological Effects and Toxicity Studies
- GDF15 and Related Biomarkers
- Nutrition, Genetics, and Disease
- Agriculture Sustainability and Environmental Impact
- Gut microbiota and health
- Muscle metabolism and nutrition
- Vitamin C and Antioxidants Research
- Amino Acid Enzymes and Metabolism
- Bone health and osteoporosis research
- Pregnancy and Medication Impact
Saarland University
2016-2025
Corewell Health Children's
2024
Johns Hopkins University
2023
Universitätsklinikum des Saarlandes
2007-2022
Aarhus University
2014-2021
University Medical Center
2016-2017
University of Bonn
2015
Ludwig-Maximilians-Universität München
2015
Klinikum rechts der Isar
2015
Otto-von-Guericke University Magdeburg
2015
V itamin B 12 deficiency is more widespread in the population than has been assumed so far (1, 2).Since a this vitamin can lead to irreversible neurological damage, early diagnosis essential (3, e1, e2).In recent years, new and sensitive diagnostic markers determine person's status have become available.It therefore important review suitability of as marker for status.This article describes causes effects presents currently available laboratory diagnosing disease.Research into (cobalamin)...
Diseases of the central nervous system are found in patients with severe hyperhomocysteinemia (HHcy). Epidemiological studies show a positive, dose-dependent relationship between mild-to-moderate increases plasma total homocysteine concentrations (Hcy) and risk neurodegenerative diseases, such as Alzheimer's disease, vascular dementia, cognitive impairment or stroke. HHcy is surrogate marker for B vitamin deficiency (folate, B12, B6) neurotoxic agent. The concept improving patient's clinical...
Background: In Germany, public interest in a vegan diet is steadily growing.There are, however, no current data on the macro-and micronutrient status of vegans.Methods: cross-sectional study entitled "The Risks and Benefits Vegan Diet" (RBVD), we investigated dietary intake, basic laboratory parameters, vitamin status, trace-element 36 vegans persons an omnivorous diet.Each group consisted 18 men women aged 30-60.Results: Nearly all one-third mixed had consumed supplements previous 4...
AimTo investigate the vitamin B status, with particular focus on B6, in adults and without incipient nephropathy secondary to type 2 diabetes mellitus.MethodsPlasma and/or urine concentrations of vitamins B1, B12, related vitamers biomarkers (including total homocysteine, methylmalonic acid) were measured 120 46 patients microalbuminuria) 52 non-diabetic control subjects.ResultsPlasma pyridoxal 5′-phosphate (PLP) significantly lower than subjects (median: 22.7 nmol/L, microalbuminuria; 26.8...
Non-alcoholic fatty liver disease (NAFLD) results from increased hepatic lipid accumulation and steatosis, is closely linked to one-carbon (C1) metabolism. We assessed in C57BL6/N mice whether NAFLD induced by a high-fat (HF) diet over 8 weeks can be reversed additional 4 of dietary methyl-donor supplementation (MDS). MDS the obese failed reverse NAFLD, but prevented progression steatosis associated with major changes key C1-metabolites, e.g. S-adenosyl-methionine S-adenosyl-homocysteine....
Scientific evidence suggests that a vegan diet might be associated with impaired bone health. Therefore, cross-sectional study (n = 36 vegans, n omnivores) was used to investigate the associations of veganism calcaneal quantitative ultrasound (QUS) measurements, along investigation differences in concentrations nutrition- and bone-related biomarkers between vegans omnivores. This revealed lower levels QUS parameters compared omnivores, e.g., broadband attenuation (vegans: 111.8 ± 10.7...
Abstract Background Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic in gestational and chronological age determination. Results Our study used data from seven tissue types on three DNA methylation profiling microarrays found that Knight Bohlin performed similarly blood cells, while Lee clock was superior placental samples. The pediatric-buccal-epigenetic best buccal samples, Horvath is recommended children's cell NeoAge...
Background/Objectives: Vitamin B12 deficiency can cause variable symptoms, which may be irreversible if not diagnosed and treated in a timely manner. We aimed to develop widely accepted expert consensus guide the practice of diagnosing treating deficiency. Methods: conducted scoping review literature published PubMed since January 2003. Data were used design two-round Delphi survey study level among 42 experts. Results: The panelists agreed on need for educational organizational changes...
Abstract Background Growing evidence demonstrates that maternal nutrition is crucial for the health of mother-to-be, and early life course offspring. However, most micronutrients, guidelines are inconsistent. This Delphi study aimed to investigate level expert consensus on micronutrient needs during preconception, pregnancy lactation. Methods We conducted a two-round web-based survey various topics including general approaches diet supplement use, existing guidelines. For periods lactation,...
The prevalence of a sub-clinical functional vitamin B12 deficiency in the general population is higher than previously expected. Total serum may not reliably indicate status. To get more specificity and sensitivity diagnosing deficiency, concept measuring holotranscobalamin II (holoTC), sub-fraction B12, has aroused great interest. HoloTC as biologically active fraction promotes specific uptake its by all cells. In this study we investigated diagnostic value storage (holoTC) markers...