A5078992692- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Pancreatic function and diabetes
- Organ Transplantation Techniques and Outcomes
- Diabetes Management and Research
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Diabetes Treatment and Management
- Renal and Vascular Pathologies
- Immune Cell Function and Interaction
- Transplantation: Methods and Outcomes
- Healthcare Policy and Management
- Organ and Tissue Transplantation Research
- Liver Disease and Transplantation
- Renal cell carcinoma treatment
- Xenotransplantation and immune response
- Cannabis and Cannabinoid Research
- Immunotherapy and Immune Responses
- Bladder and Urothelial Cancer Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Rabies epidemiology and control
- Cell Adhesion Molecules Research
- HIV Research and Treatment
Seton Medical Center
2024
The University of Texas at Austin
2020-2023
DELL (United States)
2023
Emory University
2012-2021
Children's Healthcare of Atlanta
2019
Emory Healthcare
2012-2016
Emory University Hospital
2014-2015
Development Fund
2015
University of California, Merced
2015
Arizona State University
2015
OBJECTIVE To describe trends of primary efficacy and safety outcomes islet transplantation in type 1 diabetes recipients with severe hypoglycemia from the Collaborative Islet Transplant Registry (CITR) 1999 to 2010. RESEARCH DESIGN AND METHODS A total 677 transplant-alone or islet-after-kidney CITR were analyzed for five overall identify any differences by early (1999–2002), mid (2003–2006), recent (2007–2010) transplant era based on annual follow-up 5 years. RESULTS Insulin independence at...
Impaired awareness of hypoglycemia (IAH) and severe hypoglycemic events (SHEs) cause substantial morbidity mortality in patients with type 1 diabetes (T1D). Current therapies are effective preventing SHEs 50-80% IAH SHEs, leaving a number at risk. We evaluated the effectiveness safety standardized human pancreatic islet product subjects whom persisted despite medical treatment.This multicenter, single-arm, phase 3 study investigational purified islets (PHPI) was conducted eight centers North...
After over a decade of discussion, analysis, and consensus-building, new kidney allocation system (KAS) was implemented on December 4, 2014. Key goals included improving longevity matching between donor kidneys recipients broadening access for historically disadvantaged subpopulations, in particular highly sensitized patients those with an extended duration dialysis but delayed referral transplantation. To evaluate the early impact KAS, we compared Organ Procurement Transplantation Network...
Eight manufacturing facilities participating in the National Institutes of Health–sponsored Clinical Islet Transplantation (CIT) Consortium jointly developed and implemented a harmonized process for manufacture allogeneic purified human pancreatic islet (PHPI) product evaluated phase 3 trial subjects with type 1 diabetes. Manufacturing was controlled by common master production batch record, standard operating procedures that included acceptance criteria deceased donor organ pancreata...
Attaining glycemic targets without severe hypoglycemic events (SHEs) is a challenging treatment goal for patients with type 1 diabetes complicated by impaired awareness of hypoglycemia (IAH). The CIT Consortium Protocol 07 (CIT-07) trial showed islet transplantation to be an effective subjects IAH and intractable SHEs. We evaluated health-related quality life (HRQOL), functional health status, utility before after pancreatic in CIT-07 participants.Four surveys, the Diabetes Distress Scale...
Belatacept, a T cell costimulation blocker, demonstrated superior renal function, lower cardiovascular risk, and improved graft patient survival in transplant recipients. Despite the potential benefits, adoption of belatacept has been limited part due to concerns regarding higher rates grades acute rejection clinical trials. Since July 2011, we have utilized belatacept-based immunosuppression regimens practice. In this retrospective analysis 745 patients undergoing transplantation at our...
Allogeneic islet transplant offers a minimally invasive option for β cell replacement in the treatment of type 1 diabetes (T1D). The CIT consortium trial purified human pancreatic islets (PHPI) patients with T1D after kidney (CIT06), National Institutes Health-sponsored phase 3, prospective, open-label, single-arm pivotal PHPI, was conducted 24 impaired awareness hypoglycemia while receiving intensive insulin therapy. PHPI were manufactured using standardized processes. transplantation...
Islet transplantation is an experimental therapy for selected patients with type 1 diabetes (T1DM). It remains limited by immunosuppressive drug toxicity, progressive loss of insulin independence, allosensitization and the need multiple islet donors. We describe our experience efalizumab‐based regimen as compared to prevailing standard regimen, Edmonton protocol. Twelve T1DM received transplants: eight were treated protocol; four daclizumab induction, a 6‐month course tacrolimus, maintenance...
The effect of CKD on the risks bariatric surgery is not well understood. Using American College Surgeons National Surgical Quality Improvement Program Participant Use File, we analyzed 27,736 patients who underwent from 2006 through 2008. Before surgery, 34 (0.12%) were undergoing long-term dialysis. Among those dialysis, 20,806 (75.0%) had a normal estimated GFR or stage 1 CKD, 5011 (18.07%) 2 1734 (6.25%) 3 94 (0.34%) 4 and 91 (0.33%) 5 CKD. In an unadjusted analysis, was directly...
Solid organ transplantation provides the best treatment for end-stage failure, but significant sex-based disparities in transplant access exist. On June 25, 2021, a virtual multidisciplinary conference was convened to address transplantation. Common themes contributing were noted across kidney, liver, heart, and lung transplantation, specifically existence of barriers referral wait listing women, pitfalls using serum creatinine, issue donor/recipient size mismatch, approaches frailty higher...
Organs from deceased donors with suspected false-positive HIV screening tests were generally discarded due to the chance that test was truly positive. However, Organ Policy Equity (HOPE) Act now facilitates use of such organs for transplantation HIV-infected (HIV+) individuals. In HOPE in Action trial, without a known infection who unexpectedly tested positive anti-HIV antibody (Ab) or nucleic acid (NAT) classified as donors. Between March 2016 and 2018, 10 had recovered transplant 21 +...
OBJECTIVE To determine long-term outcomes for islet-alone and islet-after-kidney transplantation in adults with type 1 diabetes complicated by impaired awareness of hypoglycemia. RESEARCH DESIGN AND METHODS This was a prospective interventional observational cohort study (n = 48) 24) transplant recipients followed up to 8 years after intraportal infusion one or more purified human pancreatic islet products under standardized immunosuppression. Outcomes included duration graft survival...
Abstract Treatment of mice with a single donor-specific transfusion plus brief course anti-CD154 mAb uniformly induces transplantation tolerance characterized by the deletion alloreactive CD8+ T cells. Survival islet allografts in treated is permanent, but skin grafts eventually fail unless recipients are thymectomized. To analyze mechanisms underlying induction, maintenance, and failure euthymic we created new analytical system based on allo-TCR-transgenic hemopoietic chimeric graft...
Background and objectives In the United States, kidney paired donation networks have facilitated an increasing proportion of transplants annually, but transplant outcome differences beyond 5 years between other living donor recipients not been well described. Design, setting, participants, & measurements Using registry-linked data, we compared National Kidney Registry ( n =2363) to control =54,497) (February 2008 December 2017). We estimated risk death-censored graft failure mortality...
The shortage of cadaveric donors for simultaneous pancreas–kidney transplantation has prompted the use organs from pediatric donors. long-term outcome and its impact on overall survival are unknown. A total 680 recipients receiving cadaver Simultaneous (SPK) adult between July 1986 September 2001 were analyzed compared. Ten-year kidney pancreas graft SPK aged <18 years (n = 142) 80% 72%, respectively, compared to 61% ≥18 age 538; p 0.03 0.05, respectively). Five post-transplant, blood...
Screening recommendations for prostate cancer remain controversial, and no specific guidelines exist screening in renal transplant candidates. To examine whether the use of prostate-specific antigen (PSA)-based patients with ESRD affects time to transplantation outcomes, we retrospectively analyzed 3782 male ≥18 years age undergoing primary evaluation during a 10-year period. Patients were grouped by per American Urological Association guidelines: group 1, <55 years; 2, 55-69 3, >69 years. A...
Abstract Patients with end‐stage renal disease ( ESRD ) demonstrate a greater risk for cell carcinoma RCC than the general population. This study compared pathological and clinical outcomes in patients without . who underwent nephrectomy were found to have at our institution since 1999 identified. The control group was composed of from population primary outcome cancer recurrence. included 338 patients: 84 243 In group, mean tumor size smaller, there decreased prevalence advanced T category...