A5002398257- Long-Term Effects of COVID-19
- Bone Metabolism and Diseases
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- Bone health and treatments
- Mycobacterium research and diagnosis
- Bacterial biofilms and quorum sensing
- Tuberculosis Research and Epidemiology
- Parasitic Infections and Diagnostics
- COVID-19 and Mental Health
- Heme Oxygenase-1 and Carbon Monoxide
- Thermal Regulation in Medicine
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Respiratory Support and Mechanisms
- Toxoplasma gondii Research Studies
- Inflammasome and immune disorders
- Veterinary medicine and infectious diseases
- Alcohol Consumption and Health Effects
- Autophagy in Disease and Therapy
- Adenosine and Purinergic Signaling
- Intensive Care Unit Cognitive Disorders
- Circular RNAs in diseases
Emory University
2016-2025
Atlanta VA Health Care System
2018-2022
Atlanta VA Medical Center
2012-2020
Veterans Health Administration
2012-2018
John Wiley & Sons (United States)
2018
The bone loss induced by ovariectomy (ovx) has been linked to increased production of osteoclastogenic cytokines marrow cells, including T cells and stromal (SCs). It is presently unknown whether regulatory interactions between these lineages contribute the effects ovx in bone, however. Here, we show that T-cell costimulatory molecule CD40 ligand (CD40L) required for expand SCs; promote osteoblast proliferation differentiation; regulate SC factors macrophage colony-stimulating factor,...
Importance SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms other health effects after the acute phase of infection; termed post-acute sequelae (PASC), long COVID. The characteristics, prevalence, trajectory and mechanisms PASC are ill-defined. objectives Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study Adults (RECOVER-Adult) to: (1) characterize prevalence; (2) symptoms, organ dysfunction, natural history, distinct phenotypes PASC; (3)...
Intermittent parathyroid hormone (iPTH) treatment stimulates T-cell production of the osteogenic Wnt ligand Wnt10b, a factor required for iPTH to activate signaling in osteoblasts and stimulate bone formation. However, it is unknown whether induces Wnt10b anabolism through direct activation (PTH)/PTH-related protein receptor (PPR) T cells. Here, we show that conditional silencing PPR cells blunts capacity induce Wnt10b; osteoblasts; expand osteoblastic pool; increase turnover, mineral...
Recruitment of neutrophils to the airways, and their pathological conditioning therein, drive tissue damage coincide with loss lung function in patients cystic fibrosis (CF). So far, these key processes have not been adequately recapitulated models, hampering drug development. Here, we hypothesized that migration naïve blood into CF airway fluid vitro would induce similar functional adaptation observed vivo, provide a model identify new therapies. We used multiple platforms (flow cytometry,...
Importance Classification of persons with long COVID (LC) or post–COVID-19 condition must encompass the complexity and heterogeneity condition. Iterative refinement classification index for research is needed to incorporate newly available data as field rapidly evolves. Objective To update 2023 adults LC using additional participant from Researching Enhance Recovery (RECOVER-Adult) study an expanded symptom list based on input patient communities. Design, Setting, Participants Prospective,...
Hyperparathyroidism in humans and continuous parathyroid hormone (cPTH) treatment mice cause bone loss by regulating the production of RANKL OPG stromal cells (SCs) osteoblasts (OBs). Recently, it has been reported that T are required for cPTH to induce as binding cell costimulatory molecule CD40L SC receptor CD40 augments sensitivity cPTH. However is unknown whether direct PTH stimulation loss, contribute catabolic activity with mechanisms other than induction signaling SCs.Here we show...
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) represent a heterogeneous group of diseases which continues to have high morbidity mortality. The molecular pathogenesis ALI is being better defined; however, because the complex nature disease therapies yet be developed. Here we use lipopolysaccharide (LPS) induced mouse model septic delineate role exosomes in inflammatory response. Using this model, were able show that mice are exposed intraperitoneal LPS secrete...
Abstract The pathogenicity of P . aeruginosa is dependent on quorum sensing (QS), an inter-bacterial communication system that can also modulate host biology. innate immune function the lung mucosal barrier proper mitochondrial function. purpose this study was to define mechanism by which bacterial factors epithelial cell and investigate novel therapies ameliorate effect. 3-oxo-C12-HSL disrupts morphology, attenuates bioenergetics, induces DNA oxidative injury. Mechanistically, we show...
ABSTRACT The pathogenic profile of Pseudomonas aeruginosa is related to its ability secrete a variety virulence factors. Quorum sensing (QS) mechanism wherein small diffusible molecules, specifically acyl-homoserine lactones, are produced by P. promote virulence. We show here that macrophage clearance (PAO1) enhanced activation the nuclear hormone receptor peroxisome proliferator-activated gamma (PPARγ). Macrophages treated with PPARγ agonist (pioglitazone) showed phagocytosis and bacterial...
Nontuberculous Mycobacteria (NTM) are a heterogeneous group of environmental microorganisms with distinct human pathogenesis. Their incidence and prevalence rising worldwide, due in part to elevated antimicrobial resistance which complicates treatment potential successful outcomes. Although information exists on the clinical significance NTMs, little is known about host immune response infection. NTM infections alter macrophage mitochondrial capacity decrease ATP production, efficient...
Childhood maltreatment and HIV are both associated with a greater risk for adverse mental health, including posttraumatic stress disorder (PTSD), depression, increased systemic inflammation. However, it remains unknown whether childhood interact to exacerbate PTSD, inflammation in manner that may further increase the of health outcomes people living HIV. This study investigated interaction between status on PTSD depression symptom severity, peripheral concentrations lipopolysaccharide (LPS)...
Summary Cryptosporidium parvum is an opportunistic intracellular parasite that causes mild to severe diarrhoea, which can be life‐threatening in immunocompromised host. To increase our understanding of the mechanisms play a role host immune responses, we investigated effects C. antigens on phenotype mouse and human dendritic cells (DCs). induced DC activation as indicated by upregulation maturation marker CD209, well production cytokines interleukin‐12 p70, IL‐2, IL‐1beta, IL‐6. In...
Pseudomonas aeruginosa is a significant contributor to recalcitrant multidrug-resistant infections, especially in immunocompromised and hospitalized patients. The pathogenic profile of P. related its ability secrete variety virulence factors promote biofilm formation. Quorum sensing (QS) mechanism wherein secretes small diffusible molecules, specifically acyl homo serine lactones, such as N-(3-oxo-dodecanoyl)-l-homoserine lactone (3O-C12-HSL), that formation via interbacterial communication....
Excessive alcohol users have a higher risk for developing respiratory infections compared to individuals who do not chronically misuse alcohol, due impaired host immune defense. In the lung, alveolar epithelial cells play critical role in defense against invading pathogens lower tract their capacity maintain barrier integrity, and macrophages key pulmonary innate immunity by phagocytizing clearing infiltrating microbes. Chronic induces mitochondrial damage that results release of DNA (mtDNA)...
Pulmonary hypertension (PH) is a progressive disorder whose cellular pathogenesis involves enhanced smooth muscle cell (SMC) proliferation and resistance to apoptosis signals. Existing evidence demonstrates that the tumor suppressor programmed death 4 (PDCD4) affects patterns of growth repair responses in systemic vasculature following experimental injury. In current study, regulation PDCD4 its functional effects on susceptibility pulmonary artery cells were explored. We previously...
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) represent a heterogeneous group of diseases which continues to have high morbidity mortality. The molecular pathogenesis ALI is being better defined; however, because the complex nature disease therapies yet be developed. Here we use lipopolysaccharide (LPS) induced mouse model septic delineate role exosomes in inflammatory response. Using this model, were able show that mice are exposed intraperitoneal LPS secrete...
T cells are required for continuous parathyroid hormone (cPTH) treatment to induce bone loss as they sensitize stromal PTH through CD40 ligand (CD40L), a surface molecule of activated cells. Since CD40L expression is feature cells, we investigated whether antigen (Ag)-mediated cell activation exert its catabolic activity. We report that inhibition Ag presentation silencing either class I or II MHC-T receptor (TCR) interaction prevents the cortical induced by in vivo cPTH treatment. also show...
IL-18 is known to play a key role limiting Cryptosporidium parvum infection. In this study, we show that depletion in SCID mice significantly exacerbates C. infection, whereas, treatment with recombinant (rIL-18), decreases the parasite load, as compared controls. Increases serum IFN-γ levels well up-regulation of antimicrobial peptides, cathelicidin peptide and beta defensin 3 (Defb3) were observed intestinal mucosa treated rIL-18. addition, infection increased mRNA expression (> 50 fold)...
The innate immune response to P. aeruginosa pulmonary infections relies on a network of pattern recognition receptors, including intracellular inflammasome complexes, which can recognize both pathogen- and host-derived signals subsequently promote downstream inflammatory signaling. Current evidence suggests that the does not contribute bacterial clearance and, in fact, dysregulated activation is harmful acute chronic lung infection. Given role mitochondrial damage recruiting signaling, we...
Cystic fibrosis (CF) is a progressive multiorgan autosomal recessive disease with devastating impact on the lungs caused by derangements of CF transmembrane conductance regulator (CFTR) gene. Morbidity and mortality are triad impaired mucociliary clearance, microbial infections chronic inflammation. Pseudomonas aeruginosa main respiratory pathogen in individuals infecting most patients later stages. Despite its recognized clinical impact, molecular mechanisms that underlie P. pathogenesis...