A5102750204- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Research
- Diabetes and associated disorders
- Circadian rhythm and melatonin
- Adipose Tissue and Metabolism
- Blood disorders and treatments
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Chronic Lymphocytic Leukemia Research
- Body Composition Measurement Techniques
- Chronic Myeloid Leukemia Treatments
- Neuroblastoma Research and Treatments
- Pancreatic function and diabetes
- Neurobiology and Insect Physiology Research
UCSF Benioff Children's Hospital
2020
Children's Hospital of Philadelphia
2013-2016
BackgroundType 1 diabetes results from autoimmune-mediated destruction of β cells. The tyrosine kinase inhibitor imatinib might affect relevant immunological and metabolic pathways, preclinical studies show that it reverses prevents diabetes. Our aim was to evaluate the safety efficacy in preserving β-cell function patients with recent-onset type diabetes.MethodsWe did a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. Patients (<100 days diagnosis), aged 18–45...
Background Diabetes ketoacidosis (DKA) is a common presentation and complication of type 1 diabetes (T1D). While intravenous insulin typically used to treat acute metabolic abnormalities, the transition from subcutaneous treatment can present challenge. We hypothesize that co-administration glargine, long-acting analog, during infusion may facilitate flexible safe therapy. Objective To determine if practice administering glargine associated with an increased risk hypoglycemia, hypokalemia,...
Abstract Background: Congenital hyperinsulinism (HI) is the leading cause of severe, persistent hypoglycemia in infants. Transient HI seen at risk neonates due to prenatal stress and some congenital cases mutations K-ATPase channel are responsive diazoxide. It not a common practice obtain genetic evaluation for diazoxide HI. However, children with dominant inactivating variants HNF4A gene may present diazoxide-responsive mimic transient infancy. Objective: To describe two siblings mutation...