A5062555298- Pain Mechanisms and Treatments
- Pain Management and Opioid Use
- Regulation of Appetite and Obesity
- Cancer Treatment and Pharmacology
- Anesthesia and Pain Management
- Adenosine and Purinergic Signaling
- Cannabis and Cannabinoid Research
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Cancer, Stress, Anesthesia, and Immune Response
- Musculoskeletal pain and rehabilitation
- Pharmacological Receptor Mechanisms and Effects
- Macrophage Migration Inhibitory Factor
- Diet and metabolism studies
- GDF15 and Related Biomarkers
- Nutrition and Health in Aging
- Estrogen and related hormone effects
- Ion channel regulation and function
- Pharmacological Effects and Toxicity Studies
- Bone health and treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Beetle Biology and Toxicology Studies
- Bariatric Surgery and Outcomes
- Fibroblast Growth Factor Research
- Biochemical Analysis and Sensing Techniques
Novo Nordisk Foundation
2018-2024
University of Copenhagen
2014-2024
University College London
2014
University College Copenhagen
2014
Max Planck Society
2006
Max Planck Institute for Human Cognitive and Brain Sciences
2006
University of Saskatchewan
1994
Abstract Growing evidence supports that pharmacological application of growth differentiation factor 15 (GDF15) suppresses appetite but also promotes sickness-like behaviors in rodents via GDNF family receptor α-like (GFRAL)-dependent mechanisms. Conversely, the endogenous regulation GDF15 and its physiological effects on energy homeostasis behavior remain elusive. Here we show, four independent human studies prolonged endurance exercise increases circulating to levels otherwise only...
Nav1.7, a peripheral neuron voltage-gated sodium channel, is essential for pain and olfaction in mice humans. We examined the role of Nav1.7 as well Nav1.3, Nav1.8, Nav1.9 different mouse models chronic pain. Constriction-injury-dependent neuropathic abolished when deleted sensory neurons, unlike nerve-transection-related pain, which requires deletion sympathetic neurons relief. Sympathetic sprouting that develops parallel with nerve-transection depends on presence neurons. Mechanical cold...
Overfeeding triggers homeostatic compensatory mechanisms that counteract weight gain. Here, we show both lean and diet-induced obese (DIO) male mice exhibit a potent prolonged inhibition of voluntary food intake following overfeeding-induced We reveal FGF21 is dispensable for this defense against Targeted proteomics unveiled novel circulating factors linked to overfeeding, including the protease legumain (LGMN). Administration recombinant LGMN lowers body in DIO mice. The protection gain...
Mechanisms of inflammatory and neuropathic pains have been elucidated translated to patient care by the use animal models these pain states. Cancer has lagged behind since early cancer-induced bone were based on systemic injection carcinoma cells. This precluded systematic investigation specific neuronal pharmacological alterations that occur in pain. In 1999, Schwei et al. described a murine model paralleled clinical condition terms development destruction, confined mouse femur. prompted...
Glucagon-like peptide-1 receptor (GLP-1R) agonists promote nicotine avoidance. Here, we show that the crosstalk between GLP-1 and extends beyond effects on self-administration can be exploited pharmacologically to amplify anti-obesity of both signals. Accordingly, combined treatment with GLP-1R agonist, liraglutide, inhibits food intake increases energy expenditure lower body weight in obese mice. Co-treatment liraglutide gives rise neuronal activity multiple brain regions, demonstrate...
Abstract Mechanical inputs give rise to p38 and JNK activation, which mediate adaptive physiological responses in various tissues. In skeletal muscle, contraction‐induced signaling ensure adaptation exercise, muscle repair, hypertrophy. However, the mechanisms by fibers sense mechanical load activate this have remained elusive. Here, we show that upstream MAP3K ZAKβ is activated cellular compression induced osmotic shock cyclic vitro , contraction vivo . This function relies on ZAKβ's...
Pain is a severe and debilitating complication of metastatic bone cancer. Current analgesics do not provide sufficient pain relief for all patients, creating great need new treatment options. The Src kinase, non-receptor protein tyrosine implicated in processes involved cancer-induced pain, including cancer growth, osteoclastic degradation nociceptive signalling. Here we investigate the role dasatinib, an oral kinase family Bcr-Abl inhibitor, animal model pain. Daily administration dasatinib...
Glucagon-like peptide 1 receptor (GLP-1R) agonists effectively improve glycemia and body weight in patients with type 2 diabetes obesity but have limited weight-lowering efficacy minimal insulin sensitizing action. In preclinical models, peripherally restricted cannabinoid (CB1R) inhibitors, which are devoid of the neuropsychiatric adverse effects observed brain-penetrant CB1R blockers, ameliorate its multiple metabolic complications. Using mouse models genetic loss or GLP-1R, we demonstrate...
Cancer-induced bone pain severely compromises the quality of life many patients suffering from metastasis, as current therapies leave some with inadequate relief. The recent development specific animal models has increased understanding molecular and cellular mechanisms underlying cancer-induced including involvement ATP purinergic receptors in progression state. In nociception, acts an extracellular messenger to transmit sensory information both at peripheral site tissue damage spinal cord....
Abstract Background Pain is a common and highly debilitating complication for cancer patients significantly compromising their quality of life. Cancer‐induced bone pain involves complex interplay multiple mechanisms including both inflammatory neuropathic processes also some unique changes. Strong opioids are mainstay treatments but side effects problematic can compromise optimal control. Tapentadol novel dual‐action drug, stimulating inhibitory μ‐opioid receptors ( MOR ) mediating...
Deep pain is neglected compared with cutaneous sources. Pressure algometry has been validated in the clinic for assessment of bone-related humans. In animal models pain, we have Randall Selitto behavioural test acute and pathological bone outcome more traditional pain-related behaviour measures.Randall pressure was performed over anteromedial part tibia naïve rats, sham-operated rats inoculated MRMT-1 carcinoma cells left tibia, effect morphine investigated. measures cancer-induced were...
Abstract Pain is a major complication for patients with cancer significantly compromising their quality of life. Current treatment far from optimal and particularly bone-related pain poses an increasing clinical socioeconomical problem. Connexins, key proteins in cell–cell communication, have the potential to affect cancer-induced bone at multiple levels, including nociceptive signaling degradation. This study tested analgesic carbenoxolone, broad-acting connexin blocker, mouse model pain....
Despite affecting millions of people, chronic pain is generally treated insufficiently. A major point focus has been the lack translation from preclinical data to clinical results, with predictive value models being a concern. In contrast current on stimulus-based nociceptive responses in research, development behavioural tests designed quantify suspension normal behaviour likely more equivalent readout for human pain-assessment tests. this study, we quantified grid-climbing as...
<ns4:p>An overwhelming amount of evidence demonstrates sex-induced variation in pain processing, and has thus increased the focus on sex as an essential parameter for optimization vivo models research. Mammary cancer cells are often used to model metastatic bone vivo, commonly both males females. Here we demonstrate that compared male rats, female rats have capacity recovery following inoculation MRMT-1 mammary cells, potentially causing a sex-dependent bias interpretation data.</ns4:p>