A5082594265- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Diet and metabolism studies
- Diabetes Treatment and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Erythrocyte Function and Pathophysiology
- Hormonal and reproductive studies
- Biochemical effects in animals
- Plant Pathogens and Fungal Diseases
- Metabolism, Diabetes, and Cancer
- Biopolymer Synthesis and Applications
- Neuroscience of respiration and sleep
- Cannabis and Cannabinoid Research
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Muscle metabolism and nutrition
- Postharvest Quality and Shelf Life Management
- Agriculture, Plant Science, Crop Management
- Agronomic Practices and Intercropping Systems
- Analytical Chemistry and Chromatography
- Genetics and Physical Performance
- Plant Physiology and Cultivation Studies
- Cancer, Lipids, and Metabolism
Neurocentre Magendie
2020-2024
Inserm
1978-2024
Université de Bordeaux
2020-2024
Centre des Sciences du Goût et de l'Alimentation
2011-2023
Université de Bourgogne
2011-2023
Centre National de la Recherche Scientifique
2012-2023
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2023
Université Bourgogne Franche-Comté
2023
Tulane University
2014-2022
CHU Dijon Bourgogne
2014
Male rats fed a diet rich in butter or stearic acid presented marked predisposition to endotoxin-initiated thrombosis. This was preceded by hypercholesterolemia, hypercoagulability, and an increased susceptibility of platelets thrombin-induced aggregation. In contrast this, feeding corn oil linoleic oleic acids did not result such changes the blood severe Gas-liquid chromatographic analysis total lipids platelet plasma indicated that thrombogenic fat fatty resulted highly significant...
The cytological changes induced in rat liver cells by the aminoazo dye 2-Me-DAB have been examined light and electron microscopy. It is observed that this non-carcinogenic compound duplicates most of morphological alterations produced other hepatotoxins, some which, such as closely related 3'-Me-DAB, are potent carcinogens. These non-specific effects involve both granular agranular forms endoplasmic reticulum well glycogen content hepatic cells. arrays cisternal profiles normal become...
Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but mechanism is unclear. In T2D, endoplasmic reticulum (ER) fails to promote proinsulin folding and, failing do so, promotes ER stress and β cell dysfunction. We show that CE prevent insulin-deficient male female Akita mice using a model misfolded proinsulin. stabilize ER-associated protein degradation (ERAD) system proteasomal degradation. This involves activation nuclear membrane estrogen...
Androgen excess predisposes women to type 2 diabetes (T2D), but the mechanism of this is poorly understood. We report that female mice fed a Western diet and exposed chronic androgen using dihydrotestosterone (DHT) exhibit hyperinsulinemia insulin resistance associated with secondary pancreatic β cell failure, leading hyperglycemia. These abnormalities are not observed in lacking receptor (AR) cells partially neurons mediobasal hypothalamus (MBH) as well AR selectively neurons. Accordingly,...
Androgen excess in women is associated with visceral adiposity. However, little known on the mechanism through which androgen promotes fat accumulation.To address this issue, female mice to chronic using 5α-dihydrotestosterone (DHT) and studied regulation of energy homeostasis was exposed.DHT induced a leptin failure decrease body weight adiposity but without alterations anorectic action. This paralleled leptin's upregulate brown adipose tissue expression uncoupling protein-1, decreased...
Estrogens favor glucose homeostasis primarily through the estrogen receptor-α (ERα), but respective importance of nuclear ERα (NOER) and membrane (MOER) pools to are unknown. We studied homeostasis, insulin secretion, sensitivity in male female mice expressing either NOER or MOER. Male MOER exhibited fasting fed hyperglycemia intolerance. Female displayed impaired central signaling associated with hyperinsulinemia resistance due unrestrained hepatic gluconeogenesis, without alterations...
Abstract The hypothalamus contains a remarkable diversity of neurons that orchestrate behavioural and metabolic outputs in highly plastic manner. Neuronal is key to enabling hypothalamic functions and, according the neuroscience dogma, it predetermined during embryonic life. Here, by combining lineage tracing pro-opiomelanocortin (Pomc) with single-cell profiling approaches adult male mice, we uncovered subpopulations ‘Ghost’ endowed atypical molecular functional identity. Compared...
Hypothalamic glucose detection participates in maintaining glycemic balance, food intake, and thermogenesis. Although hypothalamic neurons are the executive cells involved these responses, there is increasing evidence that astrocytes participate sensing (GS); however, it unknown whether astroglial networking required for sensitivity. Astroglial connexins 30 43 (Cx30 Cx43) form hexameric channels, which apposed gap junctions, allowing intercellular transfer of small molecules such as...
The endogenous estrogen 17β-estradiol (E2) promotes metabolic homeostasis in premenopausal women. In a mouse model of post-menopausal syndrome, we reported that estrogens increased energy expenditure, thus preventing deficiency-induced adiposity. Estrogens' prevention fat accumulation was associated with serum concentrations fibroblast growth factor 21 (FGF21), suggesting FGF21 participates estrogens' promotion expenditure. We studied the effect E2 on production and role stimulation...
The contribution of genetic and environmental factors in serum triglycerides (TG), total cholesterol (CHOL), low density lipoprotein (LDL-C), high (HDL-C), HDL-C/CHOL ratio were studied 1630 subjects from 375 families French descent by using a path analysis procedure. Familial correlations computed several pairs biological relatives adoption after adjustment for age gender effects further physical fitness, level habitual activity, body fat distribution, diet, smoking, alcohol consumption....
Hypothalamic mitochondrial reactive oxygen species (mROS)-mediated signaling has been recently shown to be involved in the regulation of energy homeostasis. However, upstream signals that control this mechanism have not yet determined. Here, we hypothesize glucose-induced fission plays a significant role mROS-dependent hypothalamic glucose sensing.Glucose-triggered translocation protein dynamin-related 1 (DRP1) mitochondria was first investigated vivo hypothalamus. Thus, show intracarotid...
Abstract To better assess the risk for transmission of severe acute respiratory syndrome–associated coronavirus (SARS-CoV), we obtained serial specimens and clinical exposure data from seven confirmed U.S. SARS patients their 10 household contacts. SARS-CoV was detected in a day-14 sputum specimen one case-patient five stool two case-patients. In case-patient, persisted at least 26 days after symptom onset. The highest amounts virus were sample sample. Residual symptoms still present...
Glucagon-like peptide 1 receptor (GLP-1R) agonists effectively improve glycemia and body weight in patients with type 2 diabetes obesity but have limited weight-lowering efficacy minimal insulin sensitizing action. In preclinical models, peripherally restricted cannabinoid (CB1R) inhibitors, which are devoid of the neuropsychiatric adverse effects observed brain-penetrant CB1R blockers, ameliorate its multiple metabolic complications. Using mouse models genetic loss or GLP-1R, we demonstrate...
We study the efficacy of a glucagon-like peptide-1 (GLP-1) and estrogen dual agonist (GLP1-E2) in pancreatic islet protection. GLP1-E2 provides superior protection from insulin-deficient diabetes induced by multiple low-dose streptozotocin (MLD-STZ-diabetes) Akita mutation mice than GLP-1 monoagonist. does not protect MLD-STZ-diabetes receptor-α (ERα)-deficient fails to prevent following receptor (GLP-1R) antagonism, demonstrating requirement GLP-1R ERα for antidiabetic actions. In MIN6 β...