A5042028642- Regulation of Appetite and Obesity
- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Biochemical Analysis and Sensing Techniques
- Diet and metabolism studies
- Computability, Logic, AI Algorithms
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Cannabis and Cannabinoid Research
- Dietary Effects on Health
- Drug Transport and Resistance Mechanisms
- Neural Networks and Applications
- Cognitive Science and Education Research
- PI3K/AKT/mTOR signaling in cancer
- Gene Regulatory Network Analysis
- Neuroscience and Neuropharmacology Research
- Pancreatic function and diabetes
- Zebrafish Biomedical Research Applications
- Cognitive Computing and Networks
Neurocentre Magendie
2018-2024
Inserm
2018-2024
Université de Bordeaux
2018-2024
University of Edinburgh
2020-2022
Discovery Centre
2020
The potential for neuronal representations of external stimuli to be modified by previous experience is critical efficient sensory processing and improved behavioral outcomes. To investigate how repeated exposure a visual stimulus affects its representation in mouse primary cortex (V1), we performed two-photon calcium imaging layer 2/3 neurons assessed responses before, during, after the presentation repetitive over 5 consecutive days. We found stimulus-specific enhancement repetitively...
Information processing is energetically expensive. In the mammalian brain, it unclear how information coding and energy use are regulated during food scarcity. Using whole-cell recordings two-photon imaging in layer 2/3 mouse visual cortex, we found that restriction reduced AMPA receptor conductance, reducing synaptic ATP by 29%. Neuronal excitability was nonetheless preserved a compensatory increase input resistance depolarized resting potential. Consequently, neurons spiked at similar...
Abstract The hypothalamus contains a remarkable diversity of neurons that orchestrate behavioural and metabolic outputs in highly plastic manner. Neuronal is key to enabling hypothalamic functions and, according the neuroscience dogma, it predetermined during embryonic life. Here, by combining lineage tracing pro-opiomelanocortin (Pomc) with single-cell profiling approaches adult male mice, we uncovered subpopulations ‘Ghost’ endowed atypical molecular functional identity. Compared...
Nutrient availability modulates reactive oxygen species (ROS) production in the hypothalamus. In turn, ROS regulate hypothalamic neuronal activity and feeding behavior. The mechanistic target of rapamycin complex 1 (mTORC1) pathway is an important cellular integrator action nutrients hormones. Here we tested hypothesis that modulation mTORC1 activity, particularly Proopiomelanocortin (POMC)-expressing neurons, mediates behavioral effects ROS.C57BL/6J mice or controls their knockout (KO)...
One of the main goals current systems neuroscience is to understand how neuronal populations integrate sensory information inform behavior. However, estimating stimulus or behavioral that encoded in high-dimensional challenging. We propose a method based on parametric copulas which allows modeling joint distributions and variables characterized by different statistics timescales. To account for temporal spatial changes dependencies between variables, we model varying copula parameters means...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)