A5018848376- Healthcare Policy and Management
- Primary Care and Health Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare cost, quality, practices
- Health Systems, Economic Evaluations, Quality of Life
- Acute Myocardial Infarction Research
- Foot and Ankle Surgery
- Tendon Structure and Treatment
- Cardiac Imaging and Diagnostics
- Orthopedic Surgery and Rehabilitation
- Patient Satisfaction in Healthcare
- Hemodynamic Monitoring and Therapy
- Emergency and Acute Care Studies
- Clinical practice guidelines implementation
- Lipoproteins and Cardiovascular Health
- Atrial Fibrillation Management and Outcomes
- International Law and Aviation
- Patient-Provider Communication in Healthcare
- Medical Malpractice and Liability Issues
- Cardiac Arrest and Resuscitation
- Lower Extremity Biomechanics and Pathologies
- Health and Medical Research Impacts
- Healthcare Systems and Technology
- Global Health Workforce Issues
- Cardiac Health and Mental Health
Press Ganey
2016-2025
Community Catalyst
2020-2025
Health Affairs
2025
Advisory Board Company (United States)
2025
Neurocentre Magendie
2022-2024
Inserm
2022-2024
Université de Bordeaux
2022-2024
Harvard University
2014-2023
Fordham University
2003-2023
Hong Kong Polytechnic University
2018-2023
Background —Cardiac complications are important causes of morbidity after noncardiac surgery. The purpose this prospective cohort study was to develop and validate an index for risk cardiac complications. Methods Results —We studied 4315 patients aged ≥50 years undergoing elective major procedures in a tertiary-care teaching hospital. main outcome measures were Major occurred 56 (2%) 2893 assigned the derivation cohort. Six independent predictors identified included Revised Cardiac Risk...
Acceleration of outcomes measurement can unlock the potential value-based health care for driving improvement. It requires a commitment to measuring minimum sufficient set every major medical condition.
Background: Major surgical procedures are performed with increasing frequency in elderly persons, but the impact of age on resource use and outcomes is uncertain. Objective: To evaluate influence perioperative cardiac noncardiac complications length stay patients undergoing surgery. Design: Prospective cohort study. Setting: Urban academic medical center. Patients: Consecutive sample 4315 50 years or older who underwent nonemergent major procedures. Measurements: (cardiac noncardiac),...
• Clinical and laboratory data from 596 patients who came to an emergency room complaining of chest pain indicated that no single variable could identify low-risk as well a normal ECG. A combination three variables—sharp or stabbing pain, history angina myocardial infarction, with pleuritic positional components was reproduced by palpation the wall—defined very-low-risk group in which ECGs did not add accuracy evaluation were potentially misleading; however, only 48 (8%) fell into this...
Background: Mobile-bearing ankle replacements have become popular outside of the United States over past two decades. The goal present study was to perform a prospective evaluation safety and efficacy mobile-bearing prosthesis treat end stage arthritis. We report results three separate cohorts patients: group Scandanavian Total Ankle Replacement (STAR) patients control fusion (the Pivotal Study Groups) another STAR total (Continued Access Group) whose surgery performed following completion...
Abstract The serine/threonine kinase RIPK1 is recruited to TNFR1 mediate proinflammatory signaling and regulate TNF-induced cell death. A deficiency results in perinatal lethality, impaired NFκB MAPK signaling, sensitivity apoptosis. Chemical inhibitor vitro–reconstitution studies suggested that displays distinct activity–dependent –independent functions. To determine the contribution of inflammation vivo, we generated knock-in mice endogenously expressing catalytically inactive D138N....
Primary care in the United States currently struggles to attract new physicians and garner investments infrastructure required meet patients' needs. We believe that absence of a robust overall strategy for entire spectrum primary is fundamental cause these struggles. To address an vision care, we offer framework based on value patients sustain improve practice. First, should be organized around subgroups with similar Second, team-based services provided each patient subgroup over its full...
Interview with Dr. Ziad Obermeyer on how collaboration between doctors and computers will help improve medical care. (11:26)Download The complexity of medicine now exceeds the capacity human mind. Computers are solution, but using them to manage this require fundamental changes in way we think about thinking, structure education research.
Interview with Dr. Thomas Lee on measures of health care quality that are most important to patients. (08:53)Download If “high-value, patient-centered care” is be more than rhetoric, organizations need measure outcomes matter patients, such as days spent at home in the last 6 months life. There substantial variation this outcome.
Patients who come to the emergency department with chest pain are a heterogeneous group. Some have ischemic heart disease that may lead serious complications, whereas others minor disorders. We performed study identify clinical factors predict which patients will complications requiring intensive care.
Rip1 is required for IkappaB kinase activation in response to tumor necrosis factor alpha (TNF-alpha) and has been implicated the Toll-like receptor 3 (TLR3) double-stranded RNA. Cytokine production impaired when rip1-/- cells are treated with TNF-alpha, poly(I-C), or lipopolysaccharide, implicating Trif-dependent TLR3 TLR4 pathways. To examine role of pathway, we generated MyD88-/- cells. Lipopolysaccharide failed stimulate NF-kappaB rip1-/-MyD88-/- cells, revealing that also TLR4-induced...
To determine whether preoperative characteristics influence quality of life outcomes 1, 6, and 12 months after joint replacement surgery.Patients (n = 222) with osteoarthritis undergoing primary surgery at a university hospital between November 1990 March 1993 were prospectively studied. Bodily pain physical function assessed preoperatively the 3 postoperative time points using Medical Outcomes Study 36 Item Short Form Health Survey.Bodily improved replacement. At 1 month surgery, despite...
The benefits of applying TQM in manufacturing are well-known: eliminating product defects, enhancing design, speeding delivery, and reducing costs. Most people readily agree with the basic premise TQM, but how many have been able to implement it successfully? What makes so difficult for permeate a company? How can an approach corporate management first develop Japan take root flourish very different climate U.S.?
The death domain kinase Rip1 is recruited to the tumor necrosis factor receptor type 1 and mediates IκB p38 MAP pathways. In response factor-α (TNF-α), we find phosphorylated ubiquitinated, suggesting that phosphorylation may stimulate its ubiquitination. To address contribution of activity ubiquitination TNF-α signaling, introduced wild a kinase-inactive form Rip1, Rip1D138N, into rip1-/- murine embryonic fibroblast cells by retroviral infection. TNF-α-induced observed in Rip1D138N cells,...