A5005538317- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Pancreatic function and diabetes
- Olfactory and Sensory Function Studies
- Mitochondrial Function and Pathology
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Neurological and metabolic disorders
- Biochemical effects in animals
- Advanced Chemical Sensor Technologies
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Adipokines, Inflammation, and Metabolic Diseases
- Dialysis and Renal Disease Management
- Diabetes Management and Research
- Electrolyte and hormonal disorders
- DNA Repair Mechanisms
- Apelin-related biomedical research
- Connexins and lens biology
- Cell Adhesion Molecules Research
- Immune Cell Function and Interaction
- Health, Medicine and Society
Centre des Sciences du Goût et de l'Alimentation
2015-2024
Centre National de la Recherche Scientifique
2015-2024
Université de Bourgogne
2014-2024
Université Toulouse III - Paul Sabatier
2000-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2022-2024
Institut Agro Dijon
2012-2023
Université Bourgogne Franche-Comté
2015-2023
Inserm
2014-2017
Université Grenoble Alpes
2017
Établissement Français du Sang
2014
OBJECTIVE—Insulin secretion involves complex events in which the mitochondria play a pivotal role generation of signals that couple glucose detection to insulin secretion. Studies on mitochondrial reactive oxygen species (ROS) generally focus chronic nutrient exposure. Here, we investigate whether transient ROS production linked glucose-induced increased respiration might act as signal for monitoring RESEARCH DESIGN AND METHODS—ROS response was investigated freshly isolated rat islets....
Pairing the selective estrogen receptor modulator bazedoxifene (BZA) with as a tissue-selective complex (TSEC) is novel menopausal therapy. We investigated estrogen, BZA and TSEC effects in preventing diabetisity ovariectomized mice during high-fat feeding. Estrogen, or prevented fat accumulation adipose tissue, liver skeletal muscle, improved insulin resistance glucose intolerance without stimulating uterine growth. energy homeostasis by increasing lipid oxidation expenditure, promoted...
We have previously reported that the insulin-responsive glucose transporter GLUT4 is strongly expressed by discrete areas of rat brain (Leloup et al. [1996] Molec. Brain Res. 38:45–53). In present study, a sensitive immunocytochemical technique has been used to analyze extensively anatomical and ultrastructural localizations in central nervous system order gain insight into physiological role this transporter. confirm numerous neurons spinal cord, whereas glial cells are more scarcely...
The physiological signaling mechanisms that link glucose sensing to the electrical activity in metabolism-regulating hypothalamus are still controversial. Although ATP production was considered main metabolic signal, recent studies show glucose-stimulated neurons is not totally dependent on this production. Here, we examined whether mitochondrial reactive oxygen species (mROS), which physiologically generated depending metabolism, may act as sensors monitor glucose-sensing response....
The ability for the brain to sense peripheral fuel availability is mainly accomplished within hypothalamus, which detects ongoing systemic nutrients and adjusts food intake metabolism as needed. Here, we hypothesized that mitochondrial reactive oxygen species (ROS) could trigger sensing of hypothalamus. For this purpose, induced acute hypertriglyceridemia in rats examined function mitochondria Hypertriglyceridemia led a rapid increase respiration ventral hypothalamus together with transient...
To ascertain the importance and mechanisms underlying role of brain glucagon-like peptide (GLP)-1 in control metabolic cardiovascular function. GLP-1 is a gut hormone secreted response to oral glucose absorption that regulates metabolism also produced brain, where its contribution central regulation homeostasis remains incompletely understood.Awake free-moving mice were infused with receptor agonist exendin-4 (Ex4) into lateral ventricle basal state or during hyperinsulinemic...
Clinical and preclinical studies have implicated glial anomalies in major depression. Conversely, evidence suggests that the activity of antidepressant drugs is based, at least part, on their ability to stimulate density and/or astrocytes, a cell population. Despite this recent evidence, little known about mechanism(s) by which astrocytes regulate emotionality. Glial cells communicate with each other through gap junction channels (GJCs), while they can also directly interact neurons...
Purpose: To measure the yield of DNA strand breaks and clustered lesions in plasmid irradiated with protons, helium nuclei, γ-rays.Materials methods: Plasmid was 1.03, 19.3 249 MeV protons (linear energy transfer = 25.5, 2.7, 0.39 keV μm – 1 respectively), 26 nuclei (25.5 μm) γ-rays (137Cs or 60Co) phosphate buffer containing 2 mM 200 glycerol. Single-and double-strand (SSB DSB) were measured by gel electrophoresis, base quantified converting them into irreparable DSB transformed...
Background Oxidative stress (OS), through excessive and/or chronic reactive oxygen species (ROS), is a mediator of diabetes-related damages in various tissues including pancreatic β-cells. Here, we have evaluated islet OS status and β-cell response to ROS using the GK/Par rat as model type 2 diabetes. Methodology/Principal Findings Localization markers was performed on whole pancreases. Using islets isolated from 7-day-old or 2.5-month-old male Wistar control rats, 1) gene expression...
OBJECTIVE Insulin plays an important role in the hypothalamic control of energy balance, especially by reducing food intake. Emerging data point to a pivotal reactive oxygen species (ROS) homeostasis regulation, but their involvement anorexigenic effect insulin is unknown. Furthermore, ROS signal derived from NADPH oxidase activation required for physiological effects peripheral cells. In this study, we investigated and feeding behavior regulation insulin. RESEARCH DESIGN AND METHODS We...
OBJECTIVE Recent data demonstrated that glucose sensing in different tissues is initiated by an intracellular redox signaling pathway physiological conditions. However, the relevance of such a mechanism metabolic disease not known. The aim present study was to determine whether brain hypersensitivity obese Zücker rats related alteration signaling. RESEARCH DESIGN AND METHODS Brain investigated vivo through evaluation electrical activity arcuate nucleus, changes reactive oxygen species...
We have previously demonstrated that central apelin is implicated in the control of peripheral glycemia, and its action depends on nutritional (fast versus fed) physiological (normal diabetic) states. An intracerebroventricular (icv) injection a high dose apelin, similar to observed obese/diabetic mice, increase fasted suggesting (i) contributes establishment diabetic state, (ii) existence hypothalamic liver axis. Using pharmacological, genetic, approaches, we aim at unraveling this system...
Hypothalamic glucose detection participates in maintaining glycemic balance, food intake, and thermogenesis. Although hypothalamic neurons are the executive cells involved these responses, there is increasing evidence that astrocytes participate sensing (GS); however, it unknown whether astroglial networking required for sensitivity. Astroglial connexins 30 43 (Cx30 Cx43) form hexameric channels, which apposed gap junctions, allowing intercellular transfer of small molecules such as...