A5045332107- Neuroscience and Neuropharmacology Research
- Connexins and lens biology
- Nicotinic Acetylcholine Receptors Study
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Trigeminal Neuralgia and Treatments
- Anesthesia and Pain Management
- Ion Transport and Channel Regulation
- Neurogenesis and neuroplasticity mechanisms
- Electrochemical sensors and biosensors
- Pain Mechanisms and Treatments
- Surgical Sutures and Adhesives
- Mitochondrial Function and Pathology
- bioluminescence and chemiluminescence research
- Botulinum Toxin and Related Neurological Disorders
- RNA regulation and disease
- Pain Management and Treatment
- Ion channel regulation and function
Uppsala University
2022-2024
Centre de Recherches sur la Cognition Animale
2015-2022
Université de Toulouse
2019-2022
Centre National de la Recherche Scientifique
2015-2022
Karolinska Institutet
2021
Montefiore Medical Center
2021
Université Toulouse III - Paul Sabatier
2015-2020
Clinical and preclinical studies have implicated glial anomalies in major depression. Conversely, evidence suggests that the activity of antidepressant drugs is based, at least part, on their ability to stimulate density and/or astrocytes, a cell population. Despite this recent evidence, little known about mechanism(s) by which astrocytes regulate emotionality. Glial cells communicate with each other through gap junction channels (GJCs), while they can also directly interact neurons...
Tau deposits in astrocytes are frequently found Alzheimer's disease (AD) and other tauopathies. Since do not express tau, the inclusions have been suggested to be of neuronal origin. However, mechanisms behind their appearance relevance for progression remain unknown. Here we demonstrate, using a battery experimental techniques that human serve as an intermediator, promoting cell-to-cell spreading pathological tau. Human engulf process, but fail fully degrade dead neurons with tau pathology,...
Abstract Background Astrocytes are crucial for maintaining brain homeostasis and synaptic function, but also tightly connected to the pathogenesis of Alzheimer’s disease (AD). Our previous data demonstrate that astrocytes ingest large amounts aggregated amyloid-beta (Aβ), then store, rather than degrade ingested material, which leads severe cellular stress. However, involvement pathological in AD-related dysfunction remains be elucidated. Methods In this study, we aimed investigate how...
Astroglial connexins (Cxs) 30 and 43 are engaged in gap junction hemichannel activities. Evidence suggests that these functional entities contribute to regulating neurotransmission, thereby influencing brain functions. In particular, preclinical clinical findings highlight a role of Cx43 animal models depression. However, the proteins response currently available psychotropic drugs is still unknown. To investigate this, we evaluated behavioural effects genetic pharmacological inactivation on...
Donepezil (DPZ) is an acetylcholinesterase inhibitor used in Alzheimer's disease to restore cognitive functions but endowed with limited efficacy. Recent studies pointed out the implication of astroglial networks processes, notably via astrocyte connexins (Cxs), proteins involved gap junction intercellular communications. Hence, we investigated impact on cognition pharmacological or genetic modulations those Cxs during DPZ challenge two rodent models disease-like memory deficits. We...
The ion pump Na+,K+-ATPase is a critical determinant of neuronal excitability; however, its role in the etiology diseases central nervous system (CNS) largely unknown. We describe here molecular phenotype Trp931Arg mutation catalytic α1 subunit an infant diagnosed with therapy-resistant lethal epilepsy. In addition to pathological CNS phenotype, we also detected renal wasting Mg2+. found that membrane expression mutant protein was low, and pumping activity lost. Arginine insertion into...
Abstract Astrocytes are glial cells organized in dynamic and structured networks the brain. These plastic networks, involving key proteins such as connexin 43 (Cx43), engaged fine neuronal tuning have recently been considered emerging therapeutic targets central nervous system disorders. We developed validated a new application of manganese-enhanced magnetic resonance imaging (MEMRI) technique allowing vivo investigations astrocyte-neuron interactions through quantification brain Cx43...
Alzheimer's disease (AD) is the most common neurodegenerative disease. Unfortunately, efficient and affordable treatments are still lacking for this disorder, it therefore urgent to identify new pharmacological targets. Astrocytes playing a crucial role in tuning of synaptic transmission several studies have pointed out severe astrocyte reactivity AD. Reactive astrocytes show altered physiology function, suggesting they could early pathophysiology
Studies suggest that astrocytic connexins (Cx) have an important role in the regulation of high brain functions through their ability to establish fine-tuned communication with neurons within tripartite synapse. In light these properties, growing evidence suggests a Cx psychiatric disorders such as major depression but also therapeutic activity antidepressant drugs. However, real impact on treatment response and underlying neurobiological mechanisms remain yet be clarified. On this ground,...
Background: Alzheimer’s disease (AD) research has relied on mouse models overexpressing human mutant A βPP; however, newer generation knock-in allow for physiological expression of amyloid-β protein precursor (AβPP) containing familial AD mutations where murine AβPP is edited with a humanized (Aβ) sequence. The AppNL-F model shown substantial similarities to brains developing late onset cognitive impairment. Objective: In this study, we aimed characterize mature primary cortical neurons...
Alzheimers disease is the most common neurodegenerative and constitute 75% of dementia cases worldwide. Unfortunately, efficient affordable treatments are still lacking for this mental illness, it therefore urgent to identify new pharmacological targets. Whereas late phases well described, recent evidence suggest synaptic impairments at a pre-amyloid β; (Aβ) plaque stage. Astrocytes playing crucial role in tuning transmission several studies have pointed out severe astrocyte reactivity...