A5082591919- Cardiac, Anesthesia and Surgical Outcomes
- Hemophilia Treatment and Research
- Venous Thromboembolism Diagnosis and Management
- Adenosine and Purinergic Signaling
- Blood Coagulation and Thrombosis Mechanisms
- Atrial Fibrillation Management and Outcomes
- Spine and Intervertebral Disc Pathology
- Health Systems, Economic Evaluations, Quality of Life
- Pharmacological Effects and Toxicity Studies
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Acute Myocardial Infarction Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Management of metastatic bone disease
- Sepsis Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Epilepsy research and treatment
- Anesthesia and Pain Management
- Hemodynamic Monitoring and Therapy
- Case Reports on Hematomas
- Peripheral Neuropathies and Disorders
- Cardiac Valve Diseases and Treatments
- Clinical practice guidelines implementation
- Balance, Gait, and Falls Prevention
- Cancer survivorship and care
Centre Hospitalier Universitaire de Reims
2018-2024
Université de Reims Champagne-Ardenne
2018-2024
Hôpital Saint-Antoine
2023
Assistance Publique – Hôpitaux de Paris
2023
Sorbonne Université
2004-2023
Institut de la Main
2023
Hôpital Lariboisière
2020-2022
Dana-Farber Brigham Cancer Center
2020
Brigham and Women's Hospital
2020
Dana-Farber Cancer Institute
2020
Valproic acid (VPA) poisoning is responsible for life-threatening neurological and metabolic impairments. Despite only low-level evidence of effectiveness, L-carnitine has been used years to prevent or reverse VPA-related toxicity. We aimed evaluate the effects treat acute VPA on time-course plasma concentrations designed a single-center cohort study including all VPA-poisoned patients admitted intensive care unit. studied toxicokinetics using nonlinear mixed-effects model-based population...
Telemedicine can be defined as the use of telecommunication technology for performing medical acts remotely by health professionals. Currently in anesthesia, teleconsultation (TC) is becoming widespread, although benefit and quality have not been well evaluated. The objective this study was to assess quality, patient satisfaction, ecological medicoeconomic impacts preanesthesia TC.
Summary Despite the need for effective and safe thromboprophylactic drugs patients with renal impairment, clinical trial data on anticoagulant agents are limited in this population. The study aim was to assess real-world setting use of once-daily 1.5 mg reduced dosage regimen fondaparinux available context. In prospective cohort study, a creatinine clearance (CrCl) 20–50 ml/ minute, undergoing total hip (THR) or knee (TKR) replacement fracture surgery (HFS) received thromboprophylaxis. Main...
Background: Vascular endothelial injury during ischemia generates apoptotic cell death and precedes apoptosis of underlying tissues. We aimed at studying the role extracellular adenosine triphosphate (ATP) on cells protection against hypoxia injury. Methods: In a hypoxic model cells, we quantified concentration ATP adenosine. The expression mRNA (ectonucleotidases, adenosine, P2 receptors) was measured. Apoptosis evaluated by cleaved caspase 3. involvement receptors signaling pathways...
Summary Tissue Factor (TF), an integral membrane glycoprotein that initiates the extrinsic pathway of blood coagulation, is thought to play a major part in coronary acute events. Adenosine, endogenous nucleoside produced by degradation intracellular adenosine triphosphate, has been shown exert many cardioprotective effects via inhibition platelets and neutrophils. This study was conducted determine whether (ADO) could modulate expression TF human monocytes. We found ADO inhibited antigen...
Fondaparinux is a synthetic antithrombotic agent with specific anti-factor Xa activity. A population pharmacokinetic model of fondaparinux, based on data obtained in patients included phase II/III trials, has been described. However, the validity this everyday practice needed to be confirmed. This study was multicenter, prospective cohort consecutive orthopaedic treated 2.5 mg fondaparinux. Anti-Xa activities were recorded 809 patients. Population parameters and inter-individual variability...
A relationship between generalized anxiety disorder (GAD) and fear of falling (FOF) has long been proposed but never specifically studied. This study aimed at analyzing the FOF GAD or symptoms, while controlling for major depressive episodes (MDE), fall risk, sociodemographic variables.Twenty-five older adults participated in this pilot study. Assessments included following: Anxiety Disorder Interview Schedule, Geriatric Inventory, Depression Scale, Falls-Efficacy Scale-International....
Regional analgesia has entered cardiac anesthesia in the form of spinal or epidural analgesia. However, risk hematoma is a constant worry. Alternative regional techniques might be applicable surgery. The purpose this study to present novel technique bilateral single-shot paravertebral blocks (BSS-PVB) for surgery via median sternotomy and compare its efficacy versus high thoracic (TEA). Fifty-two patients were compared prospective cohort audit. In 26 patients, was performed using low-dose...
We retrospectively analysed the data files of 171 adults and 87 children/adolescents with severe haemophilia, except for 14 patients (moderate; minor) (1), to develop a global population pharmacokinetic (PK) model eight factors VIII (FVIII) that could estimate individual PK parameters targeting desired level FVIII activity (FVIII:C); (2) compare half-life (HL) in switching from standard (SHL) an extended (EHL) evaluate relevance switch. One-stage clotting assay measurement (FVIII:C, IU/mL)...
Bleeding severity in severe haemophilic patients, with low thrombin generation (TG) capacity, can vary widely between possibly reflecting differences tissue factor pathway inhibitor (TFPI) level.
Background: Several studies have reported the beneficial effects of anti-platelet drugs in cardioprotection against ischaemia–reperfusion injuries. To date, no focused on indirect cytoprotective ticagrelor via adenosine receptor endothelium. Method: By evaluating cell viability and cleaved caspase 3 expression, we validated a model endothelial apoptosis induced by hypoxia. In hypoxic cells treated with ticagrelor, quantified extracellular concentration adenosine, then studied involvement...
BackgoundAn exercise program involving patients, caregivers, and professionals, entitled SPecific Retraining in INTerdisciplinarity (SPRINT), has been developed to prevent functional decline during hospitalization of older patients.GoalAssess the feasibility implementing SPRINT context a Geriatric Assessment Unit (GAU).MethodsGAU’s health-care professionals were instructed with SPRINT. All new patients evaluated by physiotherapist shortly after admission validate eligibility criteria...
Cell therapy is an emerging potential biotherapy for critical limb ischaemia (CLI) patients who are not eligible revascularization. However, the findings on this technique's efficacy inconsistent. Trials investigating topic focused more severe CLI were often beyond any therapy. Therefore, identifying those may truly benefit from cell transplantation now warranted. To end, we studied prognostic value of tcPO2 major amputation after 1 year in treated with bone marrow-derived cells.CLI...
Introduction Severe haemophilia is a rare disease characterised by spontaneous bleeding from early childhood, which may lead to various complications, especially in joints. It nowadays possible avoid these complications thanks substitutive therapies for the issue of adherence major. The transition adolescence adulthood young people with severe critical period as it associated high risk lack healthcare, might have serious consequences on daily activities and quality life. Methods analysis We...
A 30-year-old woman presented at 19 weeks of gestation with symptoms sore throat, rhinorrhea and haemoptysis that progressed to massive haemoptysis. Her medical history included asthma a smoking prior pregnancy. Investigations revealed no obvious cause bleeding. Right lower lobe lobectomy was performed, given the suspicion lesion within intermediate bronchus. The patient developed adult respiratory distress syndrome around 36 h postoperatively. Polymerase chain reaction testing on...