A5067683186- Poisoning and overdose treatments
- Forensic Toxicology and Drug Analysis
- Cardiac Ischemia and Reperfusion
- Adenosine and Purinergic Signaling
- Epilepsy research and treatment
- Rheumatoid Arthritis Research and Therapies
- Schizophrenia research and treatment
- Anesthesia and Pain Management
- Hormonal Regulation and Hypertension
- Cannabis and Cannabinoid Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Anesthesia and Sedative Agents
- Glaucoma and retinal disorders
- Nausea and vomiting management
- Diabetes Treatment and Management
- Bipolar Disorder and Treatment
- Diabetes Management and Research
- Pancreatic function and diabetes
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- Monoclonal and Polyclonal Antibodies Research
- Adrenal and Paraganglionic Tumors
- Autoimmune and Inflammatory Disorders Research
- Cardiac Arrhythmias and Treatments
Université de Reims Champagne-Ardenne
2016-2025
Centre Hospitalier Universitaire de Reims
2016-2025
Université de Rouen Normandie
2017-2024
Inserm
2017-2024
Hôpital Robert-Debré
2013-2023
Normandie Université
2018-2022
Hémostase et Dynamique Cellulaire Vasculaire
2013-2021
Hôpital Maison Blanche
2015-2020
Centre Hospitalier de Valenciennes
2019
Centre Hospitalier Universitaire de Rouen
2018
OBJECTIVE Neonatal diabetes secondary to mutations in potassium-channel subunits is a rare disease but constitutes paradigm for personalized genetics-based medicine, as replacing the historical treatment with insulin injections oral sulfonylurea (SU) therapy has been proven beneficial. SU receptors are widely expressed brain, and we therefore evaluated potential effects of on neurodevelopmental parameters, which known be unresponsive insulin. RESEARCH DESIGN AND METHODS We conducted...
This study reports preclinical data showing that the interleukin (IL)-1β modulation is a new promising target in pathophysiological context of heart failure. Indeed, nondiabetic Wistar and diabetic Goto-Kakizaki rats with chronic failure induced by myocardial infarction, administration IL-1β antibody gevokizumab improves 'surrogate' markers survival (i.e., left ventricular remodeling, hemodynamics, function as well coronary function). However, whether per se or combination standard...
Abstract Experimental models of cardiovascular diseases largely depend on the genetic background. Subtotal 5/6 nephrectomy (5/6 Nx) is most frequently used model chronic kidney disease (CKD) in rodents. However, mice, consequences Nx are rarely reported details and comparative results between strains scarce. The present study detailed compared outcomes 2 main mice research, 129/Sv C57BL/6JRj. Twelve weeks after Nx, CKD was demonstrated by a significant increase plasma creatinine both...
Abstract Background Septic shock is commonly associated with reduction in vasomotor tone, mainly due to vascular hyporesponsiveness norepinephrine (NE). Although the diastolic arterial pressure (DAP)/heart rate (HR) ratio reflects it cannot be a reliable index of responsiveness NE (VNERi). We hypothesized that adjusting DAP/HR for dose could yield VNERi value (VNERi = DAP/(NE x HR)), knowledge which can help guiding therapeutic strategies cases persistent hypotension despite (e.g.,...
Abstract Background Acute kidney injury (AKI) requiring renal replacement therapy (RRT) is common in intensive care units (ICUs), yet optimal amikacin dosing this context remains poorly understood. Methods We conducted a prospective observational study across 18 French hospitals from April 2020 to January 2022. Adult ICU patients (aged > years) receiving their first dose while on RRT were included. Data demographics, modalities, dosing, and therapeutic drug monitoring collected. Using...
Background: Binge eating disorder (BED) is very frequently observed in patients considered for weight loss surgery and seems to influence their outcome critically. Literature highlights a global emotional overload individuals with BED, but little known on the mechanisms involved. The present study aimed focus emotion regulation, impulsivity, depression, anxiety people without BED fulfilling inclusion criteria bariatric surgery. Doing so, we sought individualize factors related BED. Then,...
Dihydropyrimidine dehydrogenase (DPD) deficiency screening is a pre-therapeutic standard to prevent severe fluoropyrimidine-related toxicity. Although several methods exist, the accuracy of their results remains debatable. In France, uracilemia measurement considered in DPD screening. The objective this study was describe hyperuracilemia (⩾16 ng/mL) rate and investigate influence hepatic renal impairment measurements since guidelines were implemented.Using cohort 1138 patients screened...
Introduction: The prevention of respiratory complications is a major issue after thoracic surgery for lung cancer, and requires adequate post-operative pain management. erector spinae plane block (ESPB) may decrease pain. objective this study was to evaluate the impact ESPB on video or robot-assisted (VATS RATS). Methods: main outcome retrospective with propensity score analysis (PSA) compare at 24 h rest cough between group that received paravertebral (PVB). Post-operative morphine...
In post-menopausal women, incidence of heart failure with preserved ejection fraction is higher than in men. Hormonal replacement therapies did not demonstrate benefits. We tested whether the non-steroidal mineralocorticoid receptor antagonist finerenone limits progression ovariectomized (OVX) mice metabolic disorders.
Despite the well-demonstrated efficacy of infliximab in inflammatory diseases, treatment failure remains frequent. Dose adjustment using Bayesian methods has shown silico its interest achieving target plasma concentrations. However, most published models have not been fully validated accordance with recommendations. This study aimed to submit these an external evaluation and verify their predictive capabilities. Eight were selected for evaluation, carried out on independent database (409...
Although the physiological role of C-terminal hydrolase domain soluble epoxide (sEH-H) is well investigated, function its N-terminal phosphatase activity (sEH-P) remains unknown.This study aimed to assess in vivo sEH-P.CRISPR/Cas9 was used generate a novel knock-in (KI) rat line lacking sEH-P activity.The KI rats has decreased metabolism lysophosphatidic acids monoacyglycerols. grew almost normally but with less weight and fat mass gain while insulin sensitivity increased compared wild-type...
Background: Metformin-associated lactic acidosis (MALA) and metformin-induced (MILA) remain controversial entities. Metformin toxic effect depends on accumulation to lead (LA), particularly during an episode of acute kidney injury (AKI). In MILA, no other condition contributing LA is found. The aims this study were describe the characteristics prognosis AKI associated with in metformin users clarify role drug different types LA.Methods: We performed a French multicenter retrospective...
Potential under- or overdose of antibiotics may occur in intensive care units due to high variability plasma concentrations. The risk is either treatment failure toxicity. Thus, therapeutic drug monitoring guide dosing adjustment, maximising antibacterial efficacy and minimising aim this study was develop validate a method for the analysis 15 including beta-lactams, linezolid, fluoroquinolones, daptomycin, clindamycin have complete panel management infections. We proposed fast, sensitive,...
To optimise the objective diagnosis of dry eye disease (DED), capabilities wide corneal epithelial mapping using optical coherence tomography (OCT) were studied and subsequently integrated into a new scoring method.Fifty-nine patients (118 eyes) with DED 55 control subjects (110 included. All underwent complete ocular surface evaluation. Corneal thickness was collected OCT for seven zones. group compared t-test, univariate receiver operating characteristic (ROC) curves calculated to define...
Dihydropyrimidine dehydrogenase (DPD) deficiency is associated with severe fluoropyrimidines-induced toxicity. As of September 2018, French recommendations call for screening DPD by plasma uracil quantification prior to all fluoropyrimidine-based chemotherapy. A dose reduction fluoropyrimidine recommended when concentration equal or greater than 16 ng/mL. This matched retrospective study assessed the impact on side effects and management DPD-deficient patients. Using a propensity score, we...
Background: Autosomal dominant polycystic kidney disease is the most frequent hereditary and generally due to mutations in PKD1 PKD2 , encoding polycystins 1 2. In autosomal disease, hypertension cardiovascular disorders are highly prevalent, but their mechanisms partially understood. Methods: Since endothelial cells express polycystin complex, where it plays a central role mechanotransduction of blood flow, we generated murine model with inducible deletion Pkd1 ( Cdh5-Cre ERT2 ; fl/fl )...
Nefopam is a nonmorphinic central analgesic, for which no recommendation exists concerning adaptation of regimen in aged patients with or without renal impairment. The objective was to describe the pharmacology nefopam obtain guidelines practical use.Elderly (n = 48), 65-99 years old, severe moderate impairment normal function, were recruited. (20 mg) administered as 30 min infusion postoperatively. Simultaneously, 1 intravenous iohexol performed, order calculate glomerular filtration rate....