A5024607832- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Renal Transplantation Outcomes and Treatments
- Genetic and Kidney Cyst Diseases
- Renal and Vascular Pathologies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Complement system in diseases
- Transplantation: Methods and Outcomes
- Long-Term Effects of COVID-19
- COVID-19 Impact on Reproduction
- Renal cell carcinoma treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Vaccine Coverage and Hesitancy
- Hepatitis B Virus Studies
- Organ Donation and Transplantation
Université de Rouen Normandie
2020-2024
Inserm
2020-2022
Normandie Université
2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with a high rate of mortality in patients ESKD, and vaccination hoped to prevent infection.
Background: Autosomal dominant polycystic kidney disease is the most frequent hereditary and generally due to mutations in PKD1 PKD2 , encoding polycystins 1 2. In autosomal disease, hypertension cardiovascular disorders are highly prevalent, but their mechanisms partially understood. Methods: Since endothelial cells express polycystin complex, where it plays a central role mechanotransduction of blood flow, we generated murine model with inducible deletion Pkd1 ( Cdh5-Cre ERT2 ; fl/fl )...
Bertrand, Dominique; Laurent, Charlotte; Lemée, Veronique; Lebourg, Ludivine; Hanoy, Mélanie; Le Roy, Frank; Nezam, Dorian; Pruteanu, Diana; Grange, Steven; de Nattes, Tristan; Lemoine, Mathilde; Candon, Sophie; Guerrot, Dominique Author Information
Immunosuppression in kidney transplant recipients with decreased graft function and histological vascular changes can be particularly challenging. The impact of a late rescue conversion to belatacept on survival this context has never been studied.We report bicentric retrospective cohort study comparing calcineurin inhibitor (CNI) switch versus CNI continuation 139 damage (cv ≥2, g + cpt ≤1, i t ≤1) low estimated glomerular filtration rate (≤40 mL/min/1.73 m²). Primary outcome was...
Kidney transplantation and dialysis are two major risk factors for severe forms of coronavirus disease 2019 (COVID-19). The dynamics the immune response to acute respiratory syndrome 2 (SARS-CoV-2) in this population remain largely unknown.We report here analysis anti-SARS-CoV-2 antibody- T cell-mediated responses 26 kidney transplant recipients (KTRs) 11 dialyzed patients (DPs) who recovered from COVID-19.After a mean time 83 ± d post-symptom onset KTRs 97 31 DPs, 20 (76.9%) 10 DPs (90.9%)...
Monoclonal antibodies have been administered to kidney transplant recipients (KTRs) with a poor or non-responder status SARS-CoV-2 vaccination. The cellular response has poorly studied in this context. We assessed the T cell 97 patients on day of injection tixagevimab/cilgavimab using an IFNγ enzyme-linked immunospot assay (ELISPOT). Among patients, 34 (35%) developed COVID-19 before injection. Twenty-nine (85.3%) had ELISPOT compatible infection. There was no difference between KTRs under...
Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent hereditary and generally due to mutations in PKD1 PKD2, encoding polycystins 1 2. In ADPKD, hypertension cardiovascular (CV) disorders are highly prevalent but their mechanisms partially understood. The objective of this study was determine whether CV ADPKD a consequence endothelial deficiency polycystin complex, rather than disease, as currently believed.Since cells express where it plays central role...