A5005160462- Eicosanoids and Hypertension Pharmacology
- COVID-19 Clinical Research Studies
- Iron Metabolism and Disorders
- Hormonal Regulation and Hypertension
- Hemoglobinopathies and Related Disorders
- Sepsis Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Long-Term Effects of COVID-19
- Diabetes and associated disorders
- Hormonal and reproductive studies
- Apelin-related biomedical research
- Acute Myocardial Infarction Research
- Diabetes Management and Research
- Neuropeptides and Animal Physiology
- Gastric Cancer Management and Outcomes
- Immunodeficiency and Autoimmune Disorders
- Pulmonary Hypertension Research and Treatments
- Nitric Oxide and Endothelin Effects
- Atrial Fibrillation Management and Outcomes
- Regulation of Appetite and Obesity
- Electrolyte and hormonal disorders
- Esophageal Cancer Research and Treatment
- Microfluidic and Capillary Electrophoresis Applications
- Ion Transport and Channel Regulation
- Adrenal Hormones and Disorders
Université de Rouen Normandie
2015-2025
Centre Hospitalier Universitaire de Rouen
2008-2024
Normandie Université
2019-2024
Hôpital Charles-Nicolle
2019
Inserm
2016
Hôpital Charles-Nicolle
2010-2014
Laboratoire de Biochimie
2010
Abstract Experimental models of cardiovascular diseases largely depend on the genetic background. Subtotal 5/6 nephrectomy (5/6 Nx) is most frequently used model chronic kidney disease (CKD) in rodents. However, mice, consequences Nx are rarely reported details and comparative results between strains scarce. The present study detailed compared outcomes 2 main mice research, 129/Sv C57BL/6JRj. Twelve weeks after Nx, CKD was demonstrated by a significant increase plasma creatinine both...
Background & Aims Excessive fructose intake is a growing public health concern, yet many individuals have lower absorption capacity than the average intake, leading to widespread chronic malabsorption. This results in intestinal spillover, disrupting gut microbiota and triggering peripheral inflammation, which, along with neuroinflammation, plays key role mood disorders. study investigates connection between malabsorption disorders by examining changes human cohort exploring their links...
Although the physiological role of C-terminal hydrolase domain soluble epoxide (sEH-H) is well investigated, function its N-terminal phosphatase activity (sEH-P) remains unknown.This study aimed to assess in vivo sEH-P.CRISPR/Cas9 was used generate a novel knock-in (KI) rat line lacking sEH-P activity.The KI rats has decreased metabolism lysophosphatidic acids monoacyglycerols. grew almost normally but with less weight and fat mass gain while insulin sensitivity increased compared wild-type...
Since December 2019, a pandemic caused by new coronavirus has spread to more than 170 countries around the world. Worsening infected patients requiring intensive care unit (ICU) admission associated with 30% of mortality. A part worsening is induced hemostasis deregulation. The aim this study was investigate association coagulation activation in COVID-19 progression. Thirty-five 99 got clinically worse. final model logistic regression analysis revealed that O 2 requirement (RR = 7.27...
Background: Autosomal dominant polycystic kidney disease is the most frequent hereditary and generally due to mutations in PKD1 PKD2 , encoding polycystins 1 2. In autosomal disease, hypertension cardiovascular disorders are highly prevalent, but their mechanisms partially understood. Methods: Since endothelial cells express polycystin complex, where it plays a central role mechanotransduction of blood flow, we generated murine model with inducible deletion Pkd1 ( Cdh5-Cre ERT2 ; fl/fl )...
Steroids play a key role in numerous physiological processes. Steroid determination is useful tool to explore various endocrine diseases. Because of its specificity, mass spectrometry considered be reference method for the steroids serum compared radioimmunoassay. This technology could progress towards more automation optimal organization clinical laboratories and ultimately benefit patients.
An accurate assessment of septic patients at risk for poor clinical outcomes is challenging clinicians in the emergency department (ED). We aimed to evaluate prognostic value procalcitonin (PCT) ED predicting death. In a retrospective study, 188 (median age 63 [IQR 51–80]) two French university hospitals were included. Patients who deceased within 30 days (20 %, n = 37) presented higher PCT admission 34.0 µg/L [5.0–71.9]) comparison with survivals 6.4 [4.1–13.1], p 0.0005). ROC curve...
Sickle cell disease (SCD) is an inherited hemoglobinopathy disorder associated with chronic hemolysis. A major complication vaso-occlusive crisis (VOC), associating frequent hospitalization, morbidity and mortality. The aim of this study was to investigate whether hemolysis biomarkers were able predict VOC risk in adult patients SCD requiring hospitalization within 1 year. This single-center prospective included at steady state or during VOC. total 182 included, 151 31 Among the 41...
Recent studies have shown that the hypothalamic neuropeptide 26RFa regulates glucose homeostasis by acting as an incretin and increasing insulin sensitivity. In this study, we further characterized role of 26RFa/GPR103 peptidergic system in global regulation using a receptor antagonist also assessed whether dysfunction occurs obese hyperglycemic mice. First, demonstrate administration GPR103 reduces glucose-induced effect sensitivity whereas, conversely, exogenous attenuates hyperglycemia....
The high-sensitivity cardiac troponin T assay of Roche Diagnostics is known to have interference with high concentrations biotin as this uses biotin-streptavidin binding detection method. As studies so far not shown if different could diverse influence on various and whether be removed by available protocol within corresponding turnaround time we aimed investigate it.Plasma samples were spiked concentration solution. Troponin tested a Cobas® 8000 module 602 analyser. Final 50, 100, 500 1000...
Recent studies performed in mice revealed that the neuropeptide 26RFa regulates glucose homeostasis by acting as an incretin and increasing insulin sensitivity. However, humans, association between regulation of is poorly documented. In this study, we have thus investigated detail distribution its receptor, GPR103, gut pancreas, determined response peptidergic system to oral challenge obese patients.Distribution GPR103 was examined immunohistochemistry using pancreas tissue sections....
Introduction. This study addressed the hypothesis that subtotal nephrectomy associated with a high-phosphorus diet (5/6Nx + P) in rats represents suitable animal model to mimic cardiovascular consequences of chronic kidney disease (CKD) including calcified aortic valve (CAVD). Indeed, latter contributes high morbidity and mortality CKD patients sorely lacks preclinical models for pathophysiological pharmacological studies. Methods. Renal function structure were compared between sham-operated...
Abstract Background: The use of heparin as an alternative to EDTA in the production plasma samples is particular interest for B-type natriuretic peptide (BNP) measurements. Lithium now widely used determination biochemical parameters, including cardiac markers. goal this study was determine feasibility measuring BNP using instead with Access 2 system (Beckman-Coulter). Methods: determined and from 24 patients within 1 h blood collection. Additional measurements were performed plasma, every...
Type 2 diabetes (T2D) and hypertension (HTN) are common risk factors of cardiovascular diseases (CVD) characterized by chronic low-grade systemic inflammation impaired endothelial function. This study aimed to assess whether levels non-enzymatic, lipoxygenase (LOX)- cytochrome P450 (CYP)-derived arachidonic acid (ARA) metabolites, which known regulators vascular homeostasis, affected HTN T2D. For this objective, 17 plasma level derivatives ARA were quantitated chromatography coupled with...
Sickle cell disease (SCD) is an inherited hemoglobinopathy disorder. The main consequence synthesis of hemoglobin S leading to chronic hemolysis associated with morbidity. aim this study was investigate Thrombin Generation Assay (TGA) assess hypercoagulability in SCD and TGA parameters as biomarkers vaso-occlusive crisis (VOC) risk hospitalization within 1 year.We performed platelet poor plasma (PPP) pM tissue factor 4 μM phospholipid-standardized concentration, duplicate for patients...