A5036719913- Fatty Acid Research and Health
- Lipid metabolism and biosynthesis
- Diet, Metabolism, and Disease
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Gut microbiota and health
- Eicosanoids and Hypertension Pharmacology
- Cancer, Lipids, and Metabolism
- Cholesterol and Lipid Metabolism
- Reproductive System and Pregnancy
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Clostridium difficile and Clostridium perfringens research
- Helminth infection and control
- Parasites and Host Interactions
- Drug Transport and Resistance Mechanisms
- Alcohol Consumption and Health Effects
- Metabolomics and Mass Spectrometry Studies
- Metabolism and Genetic Disorders
- Retinal Diseases and Treatments
- Dietary Effects on Health
- Antioxidant Activity and Oxidative Stress
- Phytoestrogen effects and research
Université de Bourgogne
2011-2024
Inserm
2011-2024
Institut Agro Dijon
2024
Centre de recherche Translationnelle en Médecine moléculaire
2009-2022
Fondation de Coopération Scientifique
2018-2021
Aix-Marseille Université
2018
CS Diagnostics
2001
University of Vienna
2001
Pharmacochimie et Pharmacologie pour le Développement
2001
Because of confounding factors, the effects dietary n-3 polyunsaturated fatty acids (PUFA) on type 1 diabetes remain to be clarified. We therefore evaluated whether fat-1 transgenic mice, a well-controlled experimental model endogenously synthesizing PUFA, were protected against streptozotocin (STZ)-induced diabetes. then aimed elucidate in vivo response at pancreatic level.β-Cell destruction was produced by multiple low-doses STZ (MLD-STZ). Blood glucose level, plasma insulin and lipid...
Background Cancer cells present a sustained de novo fatty acid synthesis with an increase of saturated and monounsaturated (MUFA) production. This change in metabolism is associated overexpression stearoyl-CoA desaturase 1 (Scd1), which catalyses the transformation acids into (e.g., oleic acid). Several reports demonstrated that inhibition Scd1 led to blocking proliferation induction apoptosis cancer cells. Nevertheless, mechanisms cell death activation remain be better understood. Principal...
Altering the gut microbiome may be beneficial to host and recently arose as a promising strategy manage obesity. Here, we investigated relative contribution of ω3 polyunsaturated fatty acid (PUFA)-mediated alterations in microbiota metabolic parameter changes mice. Four groups were compared: male fat-1 transgenic mice (with constitutive production PUFAs) wild-type (WT) littermates fed an obesogenic (high fat/high sucrose [HFHS]) or control diet. Unlike WT mice, HFHS-fed protected against...
To investigate further the mechanisms of developmental programming, we analysed effects maternal overnutrition and postnatal high-fat feeding on adipose tissue metabolism in offspring. Postnatal changes serum adiponectin, leptin TAG [triacylglycerol (triglyceride)] levels, TAGs, fatty acids enzyme activities were determined offspring cafeteria-diet-fed dams during gestation lactation, weaned to standard chow or cafeteria diet. Obese rats showed higher adiposity (+35% 85%) as well a...
High-fat diets alter gut barrier integrity, leading to endotoxemia by impacting epithelial functions and inducing endoplasmic reticulum (ER) stress in intestinal secretory goblet cells. Indeed, ER stress, which is an important contributor many chronic diseases such as obesity obesity-related disorders, leads altered synthesis secretion of mucins that form the protective mucus barrier. In present study, we investigated relative contribution omega-3 polyunsaturated fatty acid (PUFAs)-modified...
Background & Aims Excessive fructose intake is a growing public health concern, yet many individuals have lower absorption capacity than the average intake, leading to widespread chronic malabsorption. This results in intestinal spillover, disrupting gut microbiota and triggering peripheral inflammation, which, along with neuroinflammation, plays key role mood disorders. study investigates connection between malabsorption disorders by examining changes human cohort exploring their links...
X‐linked adrenoleukodystrophy (X‐ALD) is a neurodegenerative disease due to defect in the ABCD1 ( ALD ) gene. , and two close homologues ABCD2 ALDR ABCD3 PMP70 ), are genes encoding ATP‐binding cassette half‐transporters of peroxisomal membrane. As overexpression or gene can reverse biochemical phenotype X‐ALD (reduced β‐oxidation very‐long‐chain fatty acids), pharmacological induction these partially redundant may represent therapeutic approach X‐ALD. We previously reported that could be...
Overexpression of the tyrosine kinase receptor, ErbB2/HER2/Neu, occurs in 25-30% invasive breast cancer (BC) with poor patient prognosis. Due to confounding factors, inconsistencies still remain regarding protective effects n-3 polyunsaturated fatty acids (PUFAs) on BC. We therefore evaluated whether fat-1 transgenic mice, endogenously synthesizing PUFAs from n-6 PUFAs, were protected against BC development, and we then aimed study vivo a mechanism potentially involved such protection. E0771...
Polyunsaturated fatty acids (PUFA) are known to repress SCD-1 gene expression, key enzyme of monounsaturated acid biosynthesis. Alterations the monounsaturated/saturated ratio have been implicated in various diseases related metabolic syndrome, including hypertension. We previously evidenced that lipogenesis end-products accumulated spontaneously hypertensive rats (SHR), and a dietary combination n-6/n-3 PUFA had hypotensive effects. Our present objective was test hypothesis these SHR liver...
Evidence suggests that alterations of glucose and lipid homeostasis induced by obesity are associated with the elevation endocannabinoid tone. The biosynthesis two main endocannabinoids, N-arachidonoylethanolamine 2-arachidonoyl-glycerol, which derive from arachidonic acid, is influenced dietary fatty acids (FAs). We investigated whether exposure to n-3 FA at a young age may decrease tissue levels prevent metabolic disorders later high-fat diet (HFD) challenge. Three-week-old mice received...
Diets high in saturated fatty acids (FA) represent a risk factor for the development of obesity and associated metabolic disorders, partly through their impact on epithelial cell barrier integrity. We hypothesized that unsaturated FA could alleviate FA-induced endoplasmic reticulum (ER) stress occurring intestinal secretory goblet cells, consequently reduced synthesis secretion mucins form protective mucus barrier. To investigate this hypothesis, we treated well-differentiated human colonic...
Background The central paradigm of ecological immunology postulates that selection acts on immunity as to minimize its cost/benefit ratio. Costs may arise because the energetic requirements immune response divert resources are no longer available for other vital functions. In addition these resource-based costs, mis-directed or over-reacting responses can be particularly harmful host. spite potential importance immunopathology, most studies dealing with evolution have neglected such non...
Chronic infections imply that the parasite and host immune system closely interact for a long time without fatal outcome. Environmental changes encountered by hosts parasites, such as coinfections, can deeply affect stability of this apparent equilibrium. Our study aimed to determine effect infectious environment on costs benefits chronic infection with gut nematode Heligmosomoides polygyrus in mice. is known its capacity actively interfere response secreting molecules dampen immunity. We...
Background Immune protection against pathogenic organisms has been shown to incur costs. Previous studies investigating the cost of immunity have mostly focused on metabolic requirements immune maintenance and activation. In addition these costs, system can induce damage host if response is mis-targeted or over-expressed. Given its non-specific nature, an over-expressed inflammatory often associated with substantial for host. Here, we investigated in reproductive function male mice....