A5033158998- Viral Infections and Vectors
- Parasites and Host Interactions
- Mosquito-borne diseases and control
- Gut microbiota and health
- Vector-borne infectious diseases
- Genetics, Aging, and Longevity in Model Organisms
- Genomics and Phylogenetic Studies
- Parasite Biology and Host Interactions
- Evolution and Genetic Dynamics
- Fire effects on ecosystems
- Genetic diversity and population structure
- Animal Ecology and Behavior Studies
- Animal Disease Management and Epidemiology
- Zoonotic diseases and public health
- Wildlife Ecology and Conservation
- Study of Mite Species
- Identification and Quantification in Food
- Helminth infection and control
- Viral Infections and Outbreaks Research
- Environmental DNA in Biodiversity Studies
- Animal Virus Infections Studies
- interferon and immune responses
- Reproductive tract infections research
- Climate Change and Health Impacts
- Aquatic Invertebrate Ecology and Behavior
Institut Méditerranéen de Biodiversité et d'Ecologie Marine et Continentale
2017-2019
Université de Bourgogne
2015-2019
Aix-Marseille Université
2010-2019
Biogéosciences
2015-2019
Centre de recherche Translationnelle en Médecine moléculaire
2016-2019
Animal, Santé, Territoires, Risques et Ecosystèmes
2019
Institut de Recherche pour le Développement
2010-2018
Centre National de la Recherche Scientifique
2010-2018
Infection et inflammation
2018
Université Bourgogne Franche-Comté
2016
High-throughput sequencing technologies offer new perspectives for biomedical, agronomical and evolutionary research. Promising progresses now concern the application of these to large-scale studies genetic variation. Such require genotyping high numbers samples. This is theoretically possible using 454 pyrosequencing, which generates billions base pairs sequence data. However several challenges arise: first in attribution each read produced its original sample, second, bioinformatic...
Rodent host dynamics and dispersal are thought to be critical for hantavirus epidemiology as they determine pathogen persistence transmission within between populations. We used landscape genetics investigate how the population of bank vole Myodes glareolus, Puumala (PUUV), vary with forest fragmentation influence PUUV epidemiology. sampled populations Ardennes, a French endemic area. inferred demographic features such size, isolation migration regard configuration. next analysed M....
Abstract Background Puumala virus, the agent of nephropathia epidemica (NE), is most prevalent hantavirus in Europe. The risk for human infection seems to be strongly correlated with prevalence virus (PUUV) populations its reservoir host species, bank vole Myodes glareolus . In humans, risks major viral diseases are affected by presence helminth infections. We therefore proposed analyse influence both community and landscape on PUUV among Ardennes, a endemic area France. Results Among 313...
Abstract To further assess the geographic occurrence, possible vectors, and prevalence of Candidatus Neoehrlichia mikurensis, we analyzed spleen tissues from 276 voles trapped close to human settlements in France; 5 were infected with organism. Sequencing showed isolates carried same genotype as bacteria that caused disease humans animals elsewhere Europe.
We analysed the influence of MHC class II Dqa and Drb genes on Puumala virus (PUUV) infection in bank voles (Myodes glareolus). considered sampled five European localities or derived from a previous experiment that showed variable success PUUV. The genetic variation observed was assessed by using single-strand conformation polymorphism pyrosequencing methods, respectively. Patterns were compared with those obtained 13 microsatellites. revealed significant differentiation between...
Abstract Summary: Characterizing genetic diversity through genotyping short amplicons is central to evolutionary biology. Next-generation sequencing (NGS) technologies changed the scale at which these type of data are acquired. SESAME a web application package that assists multiplexed individuals for several markers based on NGS amplicon sequencing. It automatically assigns reads loci and individuals, corrects if standard samples available provides an intuitive graphical user interface (GUI)...
Abstract The close relationships between hosts and their microbiota underlie the current concept of holobionts. This biological entity enlarges our perception genomic diversity supported by individuals/species potential abilities to respond environment. We investigated a total 54 specimens sofie fish Parachrondrostoma toxostoma (Pt) for taxonomic functional composition associated with skin, gills, gut tissues. Five wild populations from Ardèche Durance river basins in Mediterranean part...
Abstract Progress in NGS technologies has opened up new opportunities for characterizing biodiversity, both individual specimen identification and environmental barcoding. Although the amount of data available to biologist is increasing, user‐friendly tools facilitate analysis have yet be developed. Our aim, with |SE|S|AM|E| B arcode, provide such support through a unified platform. The sequences are analysed pipeline that (i) processes amplicon runs, filtering markers samples, (ii) builds...
Chronic infections imply that the parasite and host immune system closely interact for a long time without fatal outcome. Environmental changes encountered by hosts parasites, such as coinfections, can deeply affect stability of this apparent equilibrium. Our study aimed to determine effect infectious environment on costs benefits chronic infection with gut nematode Heligmosomoides polygyrus in mice. is known its capacity actively interfere response secreting molecules dampen immunity. We...
Le campagnol roussâtre Myodes glareolus est le réservoir de l’hantavirus Puumala (PUUV), responsable chez l’Homme d’une forme atténuée Fièvre Hémorragique à Syndrome Rénal (FHSR), la Néphropathie Épidémique (NE). En Europe, l’incidence NE présente, malgré distribution continue du réservoir, une forte variabilité géographique dont les causes ne sont ce jour pas identifiées. Aux hypothèses climatiques et paysagères, nous proposons que des facteurs intrinsèques aux campagnols puissent également...
Aging is associated with a decline of performance leading to reduced reproductive output and survival. While the antagonistic pleiotropy theory aging has attracted considerable attention, molecular/physiological functions underlying early-life benefits/late-life costs paradigm remain elusive. We tested hypothesis that while early activation inflammatory response confers benefits in terms protection against infection, it also incurs at old age shortened longevity. infected mice malaria...
ABSTRACT Many parasitic nematodes establish chronic infections. This implies a finely tuned interaction with the host immune response in order to avoid infection clearance. Although number of interference mechanisms have been described nematodes, how parasites adapt environment provided by their hosts remains largely unexplored. Here, we used gastrointestinal nematode Heligmosomoides polygyrus investigate plasticity life history traits and immunomodulatory intestinal inflammation. We adopted...
ABSTRACT Understanding how host dynamics, including variations of population size and dispersal, may affect the epidemiology infectious diseases through ecological evolutionary processes is an active research area. Here we focus on a bank vole ( Myodes glareolus ) metapopulation surveyed in Finland between 2005 2009. Bank reservoir Puumala hantavirus (PUUV), agent nephropathia epidemica (NE, mild form hemorrhagic fever with renal symptom) humans. M populations experience multiannual density...