A5072616070- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Circadian rhythm and melatonin
- Neuropeptides and Animal Physiology
- Suicide and Self-Harm Studies
- Neurobiology and Insect Physiology Research
- Hypothalamic control of reproductive hormones
- Light effects on plants
- Receptor Mechanisms and Signaling
- Diabetes Treatment and Management
- Muscle activation and electromyography studies
- Adipose Tissue and Metabolism
- Estrogen and related hormone effects
- Smoking Behavior and Cessation
- Parkinson's Disease Mechanisms and Treatments
- Congenital Heart Disease Studies
- Neuroendocrine regulation and behavior
- Pulmonary Hypertension Research and Treatments
- Nicotinic Acetylcholine Receptors Study
- Bariatric Surgery and Outcomes
- Effects and risks of endocrine disrupting chemicals
- Epilepsy research and treatment
- Genetic Neurodegenerative Diseases
- Balance, Gait, and Falls Prevention
- Blood transfusion and management
Centre Hospitalier Universitaire de Montpellier
2013-2024
Inserm
2015-2024
Université de Rouen Normandie
2015-2024
Université de Montpellier
2008-2024
Institut de Génomique Fonctionnelle
2024
Clinical Investigation Center Plurithematic Tours
2015-2024
Différenciation et Communication Neuronale et Neuroendocrine
2016-2023
Normandie Université
2017-2023
Institute for Research and Innovation in Biomedicine
2015-2023
Neuroendocrine, Endocrine and Germinal Differentiation Communication
2017-2023
Primary generalized dystonia (PGD) is a medically refractory disease of the brain causing twisting or spasmodic movements and abnormal postures. In more than 30% cases it associated with autosomal DYT1 mutation. Continuous electrical stimulation globus pallidus internus (GPi) has been used successfully in treatment PGD. The aim this study was to examine long-term efficacy safety deep (DBS) PGD children adults without mutation.Thirty-one patients were selected for surgery. Electrodes...
Cryptochromes are a class of flavoprotein blue-light signaling receptors found in plants, animals, and humans that control plant development the entrainment circadian rhythms. In cryptochromes, light activation is proposed to result from photoreduction protein-bound flavin chromophore through intramolecular electron transfer. However, although similar structure light-response mechanism animal cryptochromes remains entirely unknown. To complicate matters further, there currently debate on...
Animal circadian clocks are based on multiple oscillators whose interactions allow the daily control of complex behaviors. The Drosophila brain contains a clock that controls rest-activity rhythms and relies upon different groups PERIOD (PER)-expressing neurons. Two distinct have been functionally characterized under light-dark cycles. Lateral neurons (LNs) express pigment-dispersing factor (PDF) drive morning activity, whereas PDF-negative LNs required for evening activity. In constant...
Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune destruction of hypocretin-producing neurons. HCRT can also occur secondary forms narcolepsy and be only temporary, suggesting it without irreversible neuronal loss. The recent discovery that patients show loss (corticotropin-releasing hormone) CRH-producing neurons suggests other mechanisms than cell-specific attack, are...
In Drosophila , light affects circadian behavioral rhythms via at least two distinct mechanisms. One of them relies on the visual phototransduction cascade. The other involves a presumptive photopigment, cryptochrome ( cry ), expressed in lateral brain neurons that control rhythms. We show here is most, if not all, larval and adult neuronal groups expressing PERIOD (PER) protein, with notable exception dorsal (DN2s) which PER cycles antiphase to all known cells. Forcing expression DN2s gave...
Main Objectives To estimate the incidence of active bleeding after cardiac surgery (AB) based on a definition directly related blood flow from chest drainage; to describe AB characteristics and its management; identify factors postoperative complications. Methods was defined as loss > 1.5 ml/kg/h for 6 consecutive hours within first 24 or in case reoperation hemostasis during 12 hours. The applied prospective longitudinal observational study involving 29 French centers; all adult patients...
Bisphenol A (BPA) is a widespread estrogenic compound. We investigated the effects of maternal exposure to BPA at reference doses on sexual behavior and neuroendocrine functions female offspring in C57BL/6J mice. The dams were orally exposed vehicle alone or vehicle-containing equivalent no observed adverse effect level (5 mg/kg body weight per day) tolerable daily intake (TDI, 0.05 from gestational day 15 until weaning. Developmental increased lordosis quotient naive females TDI dose only....
Taking regular walks when living with Parkinson’s disease (PD) has beneficial effects on movement and quality of life. Yet, patients usually show reduced physical activity compared to healthy older adults. Using auditory stimulation such as music can facilitate walking but vary significantly in their response. An individualized approach adapting musical tempo patients’ gait cadence, capitalizing these individual differences, is likely provide a rewarding experience, increasing motivation for...
The actual distortion present in a given series of magnetic resonance (MR) images is difficult to establish. purpose this study was validate an MR imaging-based methodology for stereotactic targeting the internal globus pallidus during electrode implantation children whom general anesthesia had been induced.Twelve (mean follow up 1 year) suffering from generalized dystonia were treated with deep brain stimulation by using head frame and imaging. To analyze influence distortions at every step...
There are human reproduction concerns associated with extensive use of bisphenol A (BPA)-containing plastic and, in particular, the leaching BPA into food and beverages. In this context, it remains unclear whether how exposure to interferes developmental organization adult activation male sexual behavior by testosterone. We evaluated oral at doses equivalent no-observed-adverse-effect-level (5 mg/kg body weight per day) tolerable daily intake (TDI) (50 μg/kg on mouse potential mechanisms...
Attempts to predict suicidal behavior within high-risk populations have so far shown insufficient accuracy. Although several psychosocial and clinical features been consistently associated with suicide attempts, investigations of latent structure in well-characterized attempters are lacking.We analyzed a sample 1,009 hospitalized that were recruited between 1999 2012. Eleven clinically relevant items related the characteristics submitted Hierarchical Ascendant Classification. Phenotypic...
Abstract Objective We aimed to identify timing distortions in production and perception of rhythmic events patients with idiopathic REM sleep behavior disorder (iRBD) as early markers Parkinson's disease (PD). Methods Rhythmic skills, clinical characteristics, dysautonomia, depression, olfaction were compared 97 participants, including 21 participants iRBD, 38 PD, controls, matched for age, gender, education level. disturbances can be easily detected dedicated motor tasks via a tablet...
Ces dernières décennies ont vu l’émergence des tests par rééchantillonnage, de randomisation ou dominance stochastique. Ce court article vise à démystifier les principes sous-jacents ces procédures statistiques parfois considérées exotiques, mais plus en utilisées recherche. L’article présente un exemple appliqué au test avec le logiciel libre droits jamovi. À la suite lecture cet article, vous serez mesure cerner atouts comparativement aux paramétriques et non-paramétriques classiques,...
Circadian clocks synchronize to the solar day by sensing diurnal changes in light and temperature. In adult <i>Drosophila</i>, brain clock that controls rest–activity rhythms relies on neurons showing Period oscillations. Nine of these are present each larval hemisphere. They can receive inputs through Cryptochrome (CRY) visual system, but temperature input pathways unknown. Here, we investigate how network responds We focused CRY-negative dorsal (DN2s), which light–dark (LD) cycles set...