A5047252144- Neuroendocrine regulation and behavior
- Effects and risks of endocrine disrupting chemicals
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Barrier Structure and Function Studies
- Circadian rhythm and melatonin
- Regulation of Appetite and Obesity
- Stress Responses and Cortisol
- Hypothalamic control of reproductive hormones
- Anesthesia and Neurotoxicity Research
- MicroRNA in disease regulation
- Ovarian function and disorders
- Neuropeptides and Animal Physiology
- Traumatic Brain Injury and Neurovascular Disturbances
- S100 Proteins and Annexins
- Diet and metabolism studies
- Ion Transport and Channel Regulation
- Drug Transport and Resistance Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Graphene and Nanomaterials Applications
- Genetic Neurodegenerative Diseases
- Trace Elements in Health
- HIV, Drug Use, Sexual Risk
- Electrolyte and hormonal disorders
- Peripheral Nerve Disorders
Sorbonne Université
2012-2025
Inserm
2011-2025
Centre National de la Recherche Scientifique
2011-2025
Institut de Biologie Paris-Seine
2016-2025
Neurosciences Paris-Seine
2014-2023
Université Paris-Seine
2020-2021
Institut National de Recherche en Santé Publique
2017
Université Paris Cité
2011-2015
Sorbonne Paris Cité
2011
Mouloud Mammeri University of Tizi-Ouzou
2011
Abstract Dysfunctions in brain cholesterol homeostasis have been extensively related to disorders. The main pathway for elimination is its hydroxylation into 24S-hydroxycholesterol by the 24-hydrolase, CYP46A1. Increasing evidence suggests that CYP46A1 has a role pathogenesis and progression of neurodegenerative disorders, increasing levels neuroprotective. However, mechanisms underlying this neuroprotection remain be fully understood. Huntington’s disease fatal autosomal dominant caused an...
A dysfunction in the blood-brain barrier (BBB) is associated with many neurological and metabolic disorders. Although sex steroid hormones have been shown to impact vascular tone, endothelial function, oxidative stress, inflammatory responses, there are still no data on role of testosterone regulation BBB structure function. In this context, we investigated effects gonadal depletion integrity capillary surrounding parenchyma male mice. Our results show increased permeability for different...
Background: Courtship behavior plays a critical role in attracting females and reproduction success. However, the effects of exposure to ubiquitous contaminant di(2-ethylhexyl) phthalate (DEHP) on these behaviors and, particular, courtship vocalizations have not been examined. Objective: The adult DEHP mating gonadotropic axis neural mechanisms involved DEHP-induced were analyzed male mice. Methods: Adult C57BL/6J males orally exposed (0, 0.5, 5, 50μg/kg/d) for 4 wk. Olfactory preference,...
Receptive ano-rectal intercourse is a major cause of HIV infection in men having sex with and heterosexuals. Current knowledge the mechanisms entry dissemination during rectal transmission scarce does not allow development preventive strategies. We investigated early steps rhesus macaques inoculated pathogenic isolate SIVmac251 necropsied four hours to nine days later. All were positive for SIV. Control heat-inactivated virus consistently negative SIV DNA was detected rectum as post by...
Ovarian oestradiol is essential for pubertal maturation and adult physiology of the female reproductive axis. It acts at central peripheral sites through two main oestrogen receptors (ER) α β. Here we investigate role ERβ on effects oestradiol, by generating a mouse line specifically lacking gene in neuronal glial cells. Central deletion delays age vaginal opening first oestrous reduces uterine weight without affecting body growth. Analysis factors necessary progression shows reduced levels...
There are human reproduction concerns associated with extensive use of bisphenol A (BPA)-containing plastic and, in particular, the leaching BPA into food and beverages. In this context, it remains unclear whether how exposure to interferes developmental organization adult activation male sexual behavior by testosterone. We evaluated oral at doses equivalent no-observed-adverse-effect-level (5 mg/kg body weight per day) tolerable daily intake (TDI) (50 μg/kg on mouse potential mechanisms...
Abstract Secretion of 17-β-estradiol (E2) by human granulosa cells can be disrupted various environmental toxicants. In the current study, we investigated whether carbon black nanoparticles (CB NPs) affect steroidogenic activity cultured cells. The cell line KGN and from patients undergoing in vitro fertilization were treated with increasing concentrations CB NPs (1 to 100 µg/mL) together or not follicle-stimulating hormone (FSH). We observed that are internalized without affecting...
Abstract Magnocellular neurons of the hypothalamic supraoptic nuclei (SON) are involved in synthesis and release two major neuropeptides: oxytocin (OT) arginine‐vassopressin (AVP). Neurochemical plasticity this system is induced by physiological conditions such as lactation, parturition dehydration, may be accompanied reversible structural affecting neurons, astrocytes extracellular matrix (ECM). The noradrenergic plays a critical role triggering chemical associated with plasticity. Matrix...
Abstract Nitric oxide (NO) and noradrenaline (NA) are suggested to be implicated in the regulation of neuropeptide secretion supraoptic nuclei (SON) paraventricular (PVN) hypothalamus. Our study demonstrates short‐term interactions between NA activity expression NO synthase (NOS) magnocellular neurons, by using an ex vivo model hypothalamic slices. In SON as well PVN, total NOS exhibited a time‐dependant increase after incubation with NA. SON, this was part consequence stimulation iNOS...
Free radicals, or reactive oxygen species (ROS), are highly byproducts of degradation. They well known for their cellular toxicity, but few studies have analyzed potential role in homeostatic processes. We investigated ROS production and function during the arginine vasopressin (AVP) hypothalamic response to hyperosmolarity. Six-week-old male C3H/HeJ mice were subjected salt loading 2 8 d. The osmotic axis was progressively activated reached a new steady-state status at d as demonstrated by...
Galanin is coexpressed with vasopressin and oxytocin in magnocellular neurons of the rat neuroendocrine hypothalamus. Various physiological stimuli, such as osmotic stimulation or lactation, that affect expression release also modulate galanin expression. Magnocellular are highly innervated by noradrenergic inputs from brainstem. The system plays a critical excitatory role activation vasopressin-expressing oxytocin-expressing neurons. Here, we have evaluated possible regulation Gal...
Background: We have previously shown that chronic exposure of adult male mice to low doses di(2-ethylhexyl) phthalate (DEHP) altered sexual behavior and induced down-regulation the androgen receptor (AR) in neural circuitry controlling this behavior. Objectives: The cellular mechanisms by DEHP alone or an environmental mixture were studied. Methods: Two-month-old C57BL/6J males exposed orally for 8 wk (0, 5, 50μg/kg/d) (50μg/kg/d) a mixture. Behavior, dendritic density per 50-μm length,...
Abstract Noradrenalin (NA) regulates the expression of arginine‐vasopressin (AVP) and oxytocin (OT) by magnocellular neurons in supraoptic nucleus (SON) hypothamalus. Nitric oxide (NO) may be one factors involved NA signaling pathway regulating AVP OT expression. To test this possibility, we used an ex vivo experimental model mouse hypothalamus slices. Increases levels SON were detected immunohistochemistry immunoenzyme assays after 1 hr 4 incubations with (10 −4 M). There was also increase...
Urotensin-II-related peptide (URP) is an eight amino-acid neuropeptide recently isolated from rat brain and considered as the endogenous ligand for GPR14 receptor. Using single double immunohistochemical labelling, in situ hybridization ultrastructural immunocytochemistry, we explored cellular subcellular localization of URP male brain. was detected numerous varicose fibres median eminence (ME) organum vasculosum laminae terminalis (OVLT) well neuronal cell bodies medial septal nucleus...
Water channel aquaporin-4 (AQP4) is the most abundant water in rodent brain and mainly expressed cerebral areas involved central osmoreception osmoregulation. The neurohypophysis release site of hypothalamic neurohormones vasopressin oxytocin, which are regulation balance. authors investigated cellular subcellular distribution AQP4 mouse before after chronic osmotic stimulation, using immunofluorescence microscopy immunoperoxidase electron microscopy. They showed that was hypophysis, neural...
Abstract The hydroosmotic balance of the body is controlled by supraoptic nuclei and paraventricular hypothalamo‐posthypophyseal complex. In response to a physiological stimulation such as an osmotic stress, (SON) undergo remarkable neurochemical morphological changes. Therefore, neuroendocrine hypothalamus particularly relevant model for studying molecular cellular mechanisms that govern these plasticity phenomena. Slices rat maintained ex vivo perfusion were used study short‐term...