A5089018757- Protein Tyrosine Phosphatases
- Endoplasmic Reticulum Stress and Disease
- Diabetes and associated disorders
- Sarcoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- Eicosanoids and Hypertension Pharmacology
- Galectins and Cancer Biology
- Mitochondrial Function and Pathology
- Mast cells and histamine
- Histiocytic Disorders and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Allergic Rhinitis and Sensitization
- Heart Rate Variability and Autonomic Control
- Sphingolipid Metabolism and Signaling
- Neurosurgical Procedures and Complications
- Congenital Anomalies and Fetal Surgery
- Zoonotic diseases and public health
- Genetic Neurodegenerative Diseases
- Respiratory Support and Mechanisms
- ATP Synthase and ATPases Research
- interferon and immune responses
- Cancer Research and Treatments
- Hepatitis B Virus Studies
- Virus-based gene therapy research
- Vascular Tumors and Angiosarcomas
Université de Rouen Normandie
2016-2024
Inserm
2013-2024
Normandie Université
2017-2024
Assistance Publique – Hôpitaux de Paris
2021-2024
Université Paris Cité
2024
Centre Hospitalier Universitaire de Rouen
2022-2024
Hôpital Necker-Enfants Malades
2021
Hôpital Charles-Nicolle
2019
Laboratoire National Henri Becquerel
2019
Institute for Research and Innovation in Biomedicine
2019
Under physiological conditions, Ca(2+) transfer from the endoplasmic reticulum (ER) to mitochondria might occur at least in part contact points between 2 organelles and involves VDAC1/Grp75/IP3R1 complex. Accumulation of into mitochondrial matrix may activate chaperone cyclophilin D (CypD) trigger permeability transition pore opening, whose role ischemia/reperfusion injury is well recognized. We questioned here whether ER play a cardiomyocyte death after hypoxia-reoxygenation.We report that...
Antiphospholipid antibodies (aPL) promote endothelial dysfunction, inflammation and procoagulant state. We investigated the effect of hydroxychloroquine (HCQ) on prothrombotic state function in mice human aortic cells (HAEC). Human aPL were injected to C57BL/6 treated or not with HCQ. Vascular eNOS assessed isolated mesenteric arteries. Thrombosis was both vitro by measuring thrombin generation time (TGT) tissue factor (TF) expression vivo measurement occlusion carotid total thrombosis area...
Although the physiological role of C-terminal hydrolase domain soluble epoxide (sEH-H) is well investigated, function its N-terminal phosphatase activity (sEH-P) remains unknown.This study aimed to assess in vivo sEH-P.CRISPR/Cas9 was used generate a novel knock-in (KI) rat line lacking sEH-P activity.The KI rats has decreased metabolism lysophosphatidic acids monoacyglycerols. grew almost normally but with less weight and fat mass gain while insulin sensitivity increased compared wild-type...
The diagnosis of mastocytosis in skin biopsies can be challenging - particularly cases with very few mast cells. More diagnostic criteria are needed.We analyzed 103 from patients and compared them inflammatory lesions normal skin. Using CD117 immunostaining, we determined the cell distribution pattern, percentage cells infiltrate, count per mm². We found that a sheet-like or subepidermal was specific for mastocytosis. most significant feature not count. above 40% fully both adults children...
Hyperglycemia is a common feature of septic patients and has been associated with poor outcome high mortality. In contrast, insulin shown to decrease mortality prevent the incidence multiorgan failure but often deleterious hypoglycemia. Protein Tyrosine Phosphatase 1B (PTP1B) negative regulator both signaling NO production, be an aggravating factor in shock. To evaluate potential therapeutic effect PTP1B blockade on glucose metabolism resistance experimental model sepsis, we assessed gene...
Introduction: Protein Tyrosine Phosphatase 1B (PTP1B) and endoplasmic reticulum stress (ERS) are involved in the septic inflammatory response. Their inhibition is associated with improved survival murine models of sepsis. The objective was to describe PTP1B ERS expression during shock human. Material Methods: Prospective study including patients admitted intensive care unit (ICU) for shock. Blood samples were collected on days 1 (D1), 3 5 (D5). Quantitative PCR (performed from whole blood)...
The impact of the local inhibition soluble epoxide hydrolase, which metabolizes vasodilator and anti-inflammatory epoxyeicosanoids, on diabetic skin microvascular dysfunction was assessed. In db/db mice, basal blood flow assessed using laser Doppler imaging similar to that control but thermal hyperemia markedly reduced. At 2 h after topical administration an aqueous gel containing hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (t-AUCB: 400 mg/L), peak...
Alveolar soft part sarcoma is a rare tumour of tissues, mostly localized in muscles or deep tissues the extremities. In occasions, this develops abdomen pelvis.
The purpose of this article is to provide a simple explanation the accreditation process applied field pathology. After defining some basic notions in quality health, and then detailing general, we focus on specific pathology with implementation management system, validation or verification methods audit structure by French committee for COFRAC. We end general considerations, insisting benefits brought entry into process.
Multi-organ AL amyloidosis is a therapeutic challenge because of light chain deposits severely damaging the function concerned organs. Cardiac involvement, which leads to concentric hypertrophy both ventricles, particularly severe and poor prognosis regardless combination chemotherapy. This case pinpoints relevance combining clinical, histological, echocardiographic information in management this complex life-threatening disease.
DNA genotyping from plasma is a useful tool for molecular characterization of NSCLC. Nevertheless, the false-negative rate justifies development methods with higher sensitivity, especially in difficult-to-reach peripheral lung tumors.
On estime aujourd’hui que pres d’un cancer sur cinq a une origine infectieuse. Avec la decouverte de nouveaux agents infectieux, ce chiffre est probablement appele augmenter dans les annees venir. En 2006, nouveau γ-retrovirus des biopsies tumeur prostatique amorca intense recherche : virus, apparente aux retrovirus murins xenotropes et baptise xenotropic MLV-related virus (XMRV), serait-il cause du prostate ? Cinq ans plus tard, l’engouement retrovirologistes retombe. Un un, arguments en...
Viruses represent an important cause of cancer in humans: infections are estimated to account for close one case out five.With the ongoing discovery new infectious agents, this number should be raising near future. In 2006, a _-retrovirus prostate biopsies launched intense research activity: could xenotropic MLV-related virus (XMRV) cancer? Five years later, initial enthusiasm retrovirologists has dramatically diminished. One by one, arguments favouring hypothesis human infection with XMRV...
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