A5022650577- Adenosine and Purinergic Signaling
- Cardiac Ischemia and Reperfusion
- Advanced Glycation End Products research
- Eicosanoids and Hypertension Pharmacology
- Calcium signaling and nucleotide metabolism
- Alcohol Consumption and Health Effects
- Neuroscience and Neuropharmacology Research
- Neurological Complications and Syndromes
- Cardiovascular Function and Risk Factors
- Pharmacological Receptor Mechanisms and Effects
- Antiplatelet Therapy and Cardiovascular Diseases
- Neuroscience of respiration and sleep
- Adipose Tissue and Metabolism
Université de Reims Champagne-Ardenne
2019-2024
Hémostase et Dynamique Cellulaire Vasculaire
2013-2020
Centre Hospitalier Universitaire de Reims
2020
Although the physiological role of C-terminal hydrolase domain soluble epoxide (sEH-H) is well investigated, function its N-terminal phosphatase activity (sEH-P) remains unknown.This study aimed to assess in vivo sEH-P.CRISPR/Cas9 was used generate a novel knock-in (KI) rat line lacking sEH-P activity.The KI rats has decreased metabolism lysophosphatidic acids monoacyglycerols. grew almost normally but with less weight and fat mass gain while insulin sensitivity increased compared wild-type...
Background: Vascular endothelial injury during ischemia generates apoptotic cell death and precedes apoptosis of underlying tissues. We aimed at studying the role extracellular adenosine triphosphate (ATP) on cells protection against hypoxia injury. Methods: In a hypoxic model cells, we quantified concentration ATP adenosine. The expression mRNA (ectonucleotidases, adenosine, P2 receptors) was measured. Apoptosis evaluated by cleaved caspase 3. involvement receptors signaling pathways...
Background: Several studies have reported the beneficial effects of anti-platelet drugs in cardioprotection against ischaemia–reperfusion injuries. To date, no focused on indirect cytoprotective ticagrelor via adenosine receptor endothelium. Method: By evaluating cell viability and cleaved caspase 3 expression, we validated a model endothelial apoptosis induced by hypoxia. In hypoxic cells treated with ticagrelor, quantified extracellular concentration adenosine, then studied involvement...