A5074805025- Reproductive Biology and Fertility
- Molecular Biology Techniques and Applications
- Tissue Engineering and Regenerative Medicine
- Sperm and Testicular Function
- Animal Genetics and Reproduction
- Cancer survivorship and care
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related cognitive impairment studies
- Graphene and Nanomaterials Applications
- Pesticide Exposure and Toxicity
- Nutrition and Health in Aging
- Cardiac Arrhythmias and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Renal and related cancers
- Tryptophan and brain disorders
- Cardiovascular Function and Risk Factors
- Weed Control and Herbicide Applications
- Cardiac Ischemia and Reperfusion
- Cardiac electrophysiology and arrhythmias
- Reproductive Physiology in Livestock
- Ovarian function and disorders
- Advanced Glycation End Products research
- Atrial Fibrillation Management and Outcomes
- Pharmacological Effects and Toxicity Studies
- Lung Cancer Research Studies
Centre Hospitalier Universitaire de Reims
2024
Université de Reims Champagne-Ardenne
2024
Institut Gustave Roussy
2022-2024
Physiologie de la Reproduction et des Comportements
2017-2022
Université de Tours
2018-2019
Centre National de la Recherche Scientifique
2018-2019
Normandie Université
2018
Université de Caen Normandie
2018
BackgroundWe aimed to generate a model of cancer-related fatigue (CRF) clinical importance two years after diagnosis breast cancer building on and behavioral factors integrating pre-treatment markers systemic inflammation.MethodsWomen with stage I-III HR+/HER2- were included from the multimodal, prospective CANTO cohort (NCT01993498). The primary outcome was global CRF (EORTC QLQ-C30≥40/100) (year-2). Secondary outcomes physical, emotional, cognitive QLQ-FA12). All candidate variables...
In the present study we tested whether regulation of metabolome in bovine oviductal fluid depended on stage oestrous cycle, side relative to ovulation and local concentrations steroid hormones. Luminal samples from both oviducts were collected preovulatory, postovulatory, mid- late luteal phases, cyclic cows at a abattoir (18–27 per side). The metabolomes assessed by proton nuclear magnetic resonance spectroscopy (H-NMR). all, 39 metabolites identified, among which amino acid glycine energy...
Currently, there is a high demand for efficient pig embryo cryopreservation procedures in the porcine industry as well genetic diversity preservation and research purposes. To date, vitrification (VIT) most method cryopreservation. Despite number of embryos survives vitro after vitrification/warming procedures, vivo survival rates transfer are variable among laboratories. So far, studies have focused on cryoprotective agents devices, while VIT effects embryonic gene expression remained...
The objective of this study was to evaluate the effect progesterone (P4), estradiol (E2), and cortisol (CO) at intraoviductal concentrations on bovine embryo development quality in vitro. After fertilization vitro matured oocytes, zygotes were cultured for 8 days synthetic oviductal fluid, supplemented with 55 ng/ml P4, 120 pg/ml E2, 40 CO, or their combination (ALL). Control embryos vehicle (0.1% ethanol). Exposure steroids did not affect developmental rate nor mean number cells per...
Abstract Background: Weight management is an integral part of survivorship care. Excess weight in BCS associated with worse clinical outcomes and quality life. Early identification at risk gaining substantial could lead to prompt tailored interventions. We aimed developing a predictive model gain that integrates clinical, behavioral biological data. Methods: included patients stage I-III BC from the CANTO cohort (NCT01993498). collects longitudinal data, including objective anthropometric...
Abstract Background: We previously developed a clinico-behavioral model of CRF and reported an increased risk severe among survivors breast cancer (BC) receiving adjuvant hormonal therapy (HT) (Di Meglio A, ASCO 2021). now aim to comprehensively explore the contribution relevant serum proteins in explaining CRF. adopted multimodal approach, both (1) hypothesis-driven, based on rationale that deregulation systemic inflammatory processes mediators immunologic or neuroendocrine activation are...
Abstract Background: Up to 35% BC survivors who receive adjuvant treatment (tx) experience severe CRCI, which has a significant impact on quality of life, disrupting daily functioning as well self-esteem, self-confidence, and work ability. However, limited tools exist predict the risk CRCI. We aimed develop comprehensive model including clinical serum inflammatory protein data. Methods: included 8875 patients (pts) with stage I-III from multicenter, prospective CANTO cohort (NCT01993498)....