A5014322702- Antibiotics Pharmacokinetics and Efficacy
- Poisoning and overdose treatments
- Forensic Toxicology and Drug Analysis
- Bacterial Identification and Susceptibility Testing
- Cannabis and Cannabinoid Research
- Drug-Induced Hepatotoxicity and Protection
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Adrenal and Paraganglionic Tumors
- Pesticide Exposure and Toxicity
- Antifungal resistance and susceptibility
- Neuroscience of respiration and sleep
- Carcinogens and Genotoxicity Assessment
- Antimicrobial Resistance in Staphylococcus
- Anesthesia and Sedative Agents
- Cancer, Hypoxia, and Metabolism
- Pharmaceutical studies and practices
- Biosimilars and Bioanalytical Methods
- Pesticide Residue Analysis and Safety
- Heavy Metal Exposure and Toxicity
- Immunotoxicology and immune responses
- Smoking Behavior and Cessation
- Anesthesia and Pain Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Alcoholism and Thiamine Deficiency
Université de Montpellier
2015-2024
Centre Hospitalier Universitaire de Montpellier
2021-2024
Inserm
2021-2024
Pathogenesis and Control of Chronic and Emerging Infections
2024
Institut Desbrest d'Epidémiologie et de Santé Publique
2022-2023
Institut Universitaire de Recherche Clinique
2023
Hôpital Robert-Debré
2017-2021
Centre Hospitalier Universitaire de Reims
2015-2021
Université de Reims Champagne-Ardenne
2015-2021
Hémostase et Dynamique Cellulaire Vasculaire
2020
Isavuconazole is a triazole antifungal agent recently recommended as first-line therapy for invasive pulmonary aspergillosis. With the COVID-19 pandemic, cases of COVID-19-associated aspergillosis (CAPA) have been described with prevalence ranging from 5 to 30%. We developed and validated population pharmacokinetic (PKpop) model isavuconazole plasma concentrations in intensive care unit patients CAPA. Nonlinear mixed-effect modeling Monolix software were used PK analysis 65 trough 18...
To investigate the population pharmacokinetics of teicoplanin in patients treated by subcutaneous (sc) and/or intravenous (iv) route.Non-linear mixed-effects modelling described concentrations from 98 with infection caused Gram-positive cocci. Monte Carlo simulations were performed to evaluate probability target attainment (PTA) various dosage regimens.Teicoplanin best a two-compartment model clearance predicted estimated glomerular filtration rate. Estimated absorption rate constant...
Despite the well-demonstrated efficacy of infliximab in inflammatory diseases, treatment failure remains frequent. Dose adjustment using Bayesian methods has shown silico its interest achieving target plasma concentrations. However, most published models have not been fully validated accordance with recommendations. This study aimed to submit these an external evaluation and verify their predictive capabilities. Eight were selected for evaluation, carried out on independent database (409...
Potential under- or overdose of antibiotics may occur in intensive care units due to high variability plasma concentrations. The risk is either treatment failure toxicity. Thus, therapeutic drug monitoring guide dosing adjustment, maximising antibacterial efficacy and minimising aim this study was develop validate a method for the analysis 15 including beta-lactams, linezolid, fluoroquinolones, daptomycin, clindamycin have complete panel management infections. We proposed fast, sensitive,...
Background: Vascular endothelial injury during ischemia generates apoptotic cell death and precedes apoptosis of underlying tissues. We aimed at studying the role extracellular adenosine triphosphate (ATP) on cells protection against hypoxia injury. Methods: In a hypoxic model cells, we quantified concentration ATP adenosine. The expression mRNA (ectonucleotidases, adenosine, P2 receptors) was measured. Apoptosis evaluated by cleaved caspase 3. involvement receptors signaling pathways...
Since the 1950s, vancomycin has remained a reference treatment for severe infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus Vancomycin is nephrotoxic and ototoxic drug mainly eliminated through kidneys. It large interindividual pharmacokinetic variability, which justifies monitoring its plasma concentrations in patients. This especially important patients aged over 80 years, who frequently have renal impairment. However, pharmacokinetics of...
Therapeutic drug monitoring (TDM) of anti-TNF-α is an important tool in clinical practice for inflammatory diseases. In this study, we have evaluated the performance several assays and antidrug antibodies (ADA) measurement serum. 50 sera from patients treated with infliximab (IFX) 49 adalimumab (ADAL) were monitored four immunoassays. We compared Promonitor, i-Track10®, ez-track1 to our gold standard Lisa Tracker® ELISA using Cohen's kappa, Passing-Bablok, Bland-Altman analysis. The...
Mitotane is the most effective agent in post-operative treatment of adrenocortical carcinoma. In adults, starting dose 2-3 g/day and should be slightly increased to reach therapeutic index 14-20 mg/L. This study developed a population PK model for mitotane simulate recommended/high dosing regimens. We retrospectively analyzed data files 38 patients with 503 plasma concentrations pharmacokinetic analysis. Monolix version 2019R1 was used non-linear mixed-effects modelling. Monte Carlo...
The goal of our study was to assess the impact patients' genetic background on their sensitivity carboplatin/paclitaxel hematotoxicity.Parameters describing neutropenia and thrombocytopenia 201 patients were extracted from a previous pharmacokinetic/pharmacodynamics analysis, in order association with 52 candidates SNPs 18 genes.Carriers T allele SLCO1B3-rs4149117 19% less sensitive than homozygotes for G (p = 0.00279). Carriers two copies ATG haplotypes NR1I2-rs1523130, rs3814055 rs1523127...
We retrospectively analysed the data files of 171 adults and 87 children/adolescents with severe haemophilia, except for 14 patients (moderate; minor) (1), to develop a global population pharmacokinetic (PK) model eight factors VIII (FVIII) that could estimate individual PK parameters targeting desired level FVIII activity (FVIII:C); (2) compare half-life (HL) in switching from standard (SHL) an extended (EHL) evaluate relevance switch. One-stage clotting assay measurement (FVIII:C, IU/mL)...
(1) Background: In toxicological laboratories, various screening methods can be used to identify compounds involved in intoxication. High-resolution mass spectrometry has been increasingly this context for the last years, because of its sensitivity and reliability. Here, we present development validation a method that uses liquid chromatography coupled with high-resolution spectrometer. (2) Methods: This required only 100 µL whole blood or plasma sample. Pretreatment consisted rapid simple...
A multiparametric liquid chromatography-tandem mass spectrometry method has been developed for the simultaneous quantification of 11 antifungal drugs and their metabolites in human plasma. This addresses critical need therapeutic drug monitoring treatment invasive fungal infections, which are increasingly prevalent among immunocompromised patients those intensive care units. The quantifies flucytosin, fluconazole, itraconazole, hydroxy-itraconazole, posaconazole, isavuconazole, voriconazole,...
•Upon diagnosing a patient, an initial automatic response arises based on pattern recognition through therapy scripts (type 1 thinking). At some point, this is evaluated by the reflective mind using metacognition (which plays important role in type 2a thinking), and if found to be incorrect or incomplete, alternative formulated slower, more analytical, deliberative process, known as 2b thinking. This process shown European Model of Therapeutic Reasoning.•Metacognition monitors reasoning...
Trivialization of cannabis consumption goes hand in with a growing exposure children and the number poisoning cases is steadily increasing. As clinical presentation can be different from what currently seen adults, added to fact that it not always suspected, diagnosis intoxication often delayed or missed. A 16-month-old girl was admitted pediatric emergency unit for an important drowsiness combined moderate fever. After elimination infectious causes, toxic origin considered biological...
The aim of this work was to define the optimal dosage (OD) ciprofloxacin in order prevent emergence bacterial resistance Pseudomonas aeruginosa a geriatric population with bloodstream infection. A thousand pharmacokinetic profiles were simulated model from literature. Three dosing regimens tested for five days: once daily (QD), twice (BID), and thrice (TID). First all, effective dosages (ED) defined as those achieving target AUC24 /MIC ≥ 125. Then, these ED calculate percentage time spent...
Adrenocortical carcinoma (ACC) is an aggressive malignancy of the adrenal gland. Mitotane (o,p'-DDD) most effective chemotherapy for ACC. According to literature, mitotane plasma trough concentrations within 14-20 mg L-1 are correlated with a higher response rate acceptable toxicity. Therapeutic drug monitoring (TDM) therefore recommended. The aim this study was propose robust and simple method quantification in plasma. validation procedures were based on international guidelines. Sample...
Abstract: We present here an example of urine substituted with a yellow cleaning product that leads us to develop the main risks consider in toxicology analysis, ie, adulteration and analytical interferences, how deal them. This grand round highlights importance dialog between clinician TDM consultant for optimal care patient.