A5072041976- Retinal Diseases and Treatments
- Adenosine and Purinergic Signaling
- Cardiac Ischemia and Reperfusion
- Retinopathy of Prematurity Studies
- Neurological Disorders and Treatments
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Glaucoma and retinal disorders
Inserm
2020-2021
Centre de Recherche des Cordeliers
2020-2021
Sorbonne Université
2020-2021
Université Paris Cité
2020-2021
Diabetic retinopathy (DR) remains a major cause of vision loss, due to macular edema, retinal ischemia and death neurons. We previously demonstrated that acute administration glibenclamide into the vitreous, or given orally at non-hypoglycemic dose, protected structure function retina in three animal models each mimic aspects diabetic humans. In this pilot study, we investigated whether one year chronic oral glibenclamide, regimen (Amglidia®, 0.4 mg/kg, Ammtek/Nordic Pharma, 5 d/week), could...