A5082737921- Cardiovascular Health and Disease Prevention
- Hormonal Regulation and Hypertension
- Lymphatic System and Diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Genetics, Aging, and Longevity in Model Organisms
- Biomarkers in Disease Mechanisms
- Ion Transport and Channel Regulation
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Congenital heart defects research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Heart Failure Treatment and Management
- Pancreatic function and diabetes
- Systemic Sclerosis and Related Diseases
- Stress Responses and Cortisol
Inserm
2018-2023
Université de Rouen Normandie
2018-2023
Zero to Three
2021
Normandie Université
2018
Lymphatics are essential for cardiac health, and insufficient lymphatic expansion (lymphangiogenesis) contributes to development of heart failure (HF) after myocardial infarction. However, the regulation impact lymphangiogenesis in non-ischaemic cardiomyopathy following pressure-overload remains be determined. Here, we investigated transversal aortic constriction (TAC) C57Bl/6 Balb/c mice, end-stage HF patients.Cardiac function was evaluated by echocardiography, hypertrophy, lymphatics,...
In post-menopausal women, incidence of heart failure with preserved ejection fraction is higher than in men. Hormonal replacement therapies did not demonstrate benefits. We tested whether the non-steroidal mineralocorticoid receptor antagonist finerenone limits progression ovariectomized (OVX) mice metabolic disorders.
Abstract Neutrophil gelatinase-associated lipocalin (NGAL) is involved in cardiovascular and renal diseases. Gene inactivation of NGAL blunts the pathophysiological consequences damage. We aimed to design chemical inhibitors investigate its effects experimental models myocardial infarction (MI) chronic kidney disease induced by 5/6 nephrectomy (CKD) on respectively 8–12 weeks old C57Bl6/j FVB/N male mice. Among 32 tested, GPZ614741 GPZ058225 fully blocked NGAL-induced inflammatory...
Abstract Long-living individuals (LLIs) escape age-related cardiovascular complications until the very last stage of life. Previous studies have shown that a Longevity-Associated Variant (LAV) BPI Fold Containing Family B Member 4 ( BPIFB4 ) gene correlates with an extraordinarily prolonged life span. Moreover, delivery LAV-BPIFB4 exerted therapeutic action in murine models atherosclerosis, limb ischemia, diabetic cardiomyopathy, and aging. We hypothesize downregulation expression marks...
Abstract Rationale Lymphatics are essential for cardiac health, and insufficient lymphatic expansion (lymphangiogenesis) contributes to development of heart failure (HF) after myocardial infarction. However, the regulation impact lymphatics in non-ischemic cardiomyopathy induced by pressure-overload remains be determined. Objective Investigate lymphangiogenesis following transverse aortic constriction (TAC) adult male or female C57Bl/6J Balb/c mice, patients with end-stage HF. Methods &...