A5090974824- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Cholesterol and Lipid Metabolism
- Calpain Protease Function and Regulation
- Birth, Development, and Health
- Cardiovascular Disease and Adiposity
- Fatty Acid Research and Health
- Pancreatic function and diabetes
- Nutritional Studies and Diet
- Retinoids in leukemia and cellular processes
- Diet, Metabolism, and Disease
- RNA regulation and disease
- Vitamin C and Antioxidants Research
- Effects and risks of endocrine disrupting chemicals
- Endoplasmic Reticulum Stress and Disease
- Plant nutrient uptake and metabolism
- Health, Environment, Cognitive Aging
- Per- and polyfluoroalkyl substances research
- Lipid metabolism and biosynthesis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Fibroblast Growth Factor Research
- Silk-based biomaterials and applications
- Connective tissue disorders research
- Erythropoietin and Anemia Treatment
Universidad Nacional Autónoma de México
2008-2024
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2011-2019
Zero to Three
2017
Secretariat of Agriculture, Livestock, Rural Development, Fisheries and Food
2013
Abstract Subcutaneous (SAT) and visceral (VAT) adipose tissues stores excess energy as triglycerides synthesize adiponectin to prevent ectopic lipid accumulation lipotoxicity. During obesity, an impairment in the capacity of SAT store is associated with increased free fatty acids (FFA) release, leading VAT hypertrophy hepatic skeletal muscle Endoplasmic reticulum (ER) stress unfolded protein response (UPR) may be involved dysfunction during obesity. The objectives this study were assess UPR...
The incidence of type 2 diabetes mellitus (T2DM) is increasing worldwide and diverse environmental genetic risk factors are well recognized. Single nucleotide polymorphisms (SNPs) in the calpain-10 gene (CAPN-10), which encodes a protein involved secretion action insulin, chronic exposure to inorganic arsenic (iAs) through drinking water have been independently associated with an increase for T2DM. In present work we evaluated if CAPN-10 SNPs iAs jointly contribute outcome Insulin (beta-cell...
The study of NAFLD in humans has several limitations. Using murine models helps to understand disease pathogenesis.Evaluate the impact 4 different diets production with emphasis on a combined high-fat plus sustained high sucrose consumption.Eight week-old male Wistar rats were divided four groups and fed for 90 days following diets: 1) Control chow diet (C); 2) High-fat cholesterol (HFC) + 5% drinking water. 3) cornstarch (HFCO) 4) Chow 20% water (HSD). Metabolic changes, leptin levels,...
The post-nutritional intervention modulation of miRNA expression has been previously investigated; however, post-acute dietary-ingestion-related dynamics in individuals with obesity and insulin resistance (IR) are unknown. We aimed to determine the acute effects protein ingestion from different dietary sources on postprandial metabolic response, amino acid levels, circulating adults IR. This clinical trial included IR who consumed (1) animal-source (AP; calcium caseinate) or (2)...
Long-term dietary and pharmacological treatments for obesity have been questioned, particularly in individuals with severe obesity, so a new approach may involve adipose tissue transplants, autologous transplants. Thus, the aim of this study was to evaluate metabolic effects subcutaneous (SAT) transplants into two specific intraabdominal cavity sites (omental retroperitoneal) after 90 days. The performed using different diet-induced (DIO) rat models: one high-fat diet (HFD) other...
A low-protein diet increases the expression and circulating concentration of FGF21. FGF21 stimulates browning process WAT by enhancing UCP1 coupled with an increase in PGC1α. Interestingly, consumption a could stimulate differentiation into beige/brite cells increasing Ucp1 mRNA abundance. However, whether stimulus on can synergistically interact another stimulus, such as cold exposure, remains elusive.In present study, rats were fed 6% (low), 20% (adequate), or 50% (high) dietary protein...
Abstract Background/Objective: Dietary fat sources modulate fasting serum concentration of adipokines, particularly adiponectin. However, previous studies utilized obese animals in which adipose tissue function is severely altered. Thus, the present study aimed to assess postprandial regulation adipokine secretion nonobese rats that consumed high-fat diet (HFD) composed different types for a short time. Methods: The were fed control or HFD containing coconut, safflower soybean oil (rich...
Scope Hyperglucagonemia contributes to hyperglycemia in type 2 diabetes (T2D). Previously, we have found that soy protein normalized fasting hyperglucagonemia obese Zucker ( fa/fa ) rats, sensitizing the HSL‐lipolytic signaling pathway white adipose tissue (WAT), however mechanism remains unknown. Methods and results rats were fed casein or diet combination with soybean coconut oil. Glucagon receptor (GR) was increased at plasma membrane of adipocytes compared those casein, without changes...
Metabolic parameters ranging from circulating nutrient levels and substrate utilization to energy expenditure thermogenesis are temporally modulated by the circadian timing system. During critical embryonic developmental periods, maternal over-nutrition could alter key elements in different tissues associated with generation of rhythmicity, compromising normal rhythmicity development. To address this issue, we determine whether leads alterations development at physiological behavioral...
P-701 Introduction: Human studies have shown that chronic inorganic arsenic (iAs) exposure is associated with a high prevalence and incidence of type 2 diabetes. However, the mechanism(s) underlying this effect are not well understood, practically, there no information available on effects pancreatic β-cells functions. Thus, since insulin secreted by pancreas plays crucial role in maintaining glucose homeostasis, our aim was to determine if sodium arsenite impairs secretion mRNA expression...