A5076753092- Lysosomal Storage Disorders Research
- Lipid Membrane Structure and Behavior
- Drug Transport and Resistance Mechanisms
- Sphingolipid Metabolism and Signaling
- Parkinson's Disease Mechanisms and Treatments
- DNA and Nucleic Acid Chemistry
- Bacterial Genetics and Biotechnology
- Cannabis and Cannabinoid Research
- DNA Repair Mechanisms
- Trypanosoma species research and implications
- Neurosurgical Procedures and Complications
- Forensic Toxicology and Drug Analysis
- Studies on Chitinases and Chitosanases
- Multiple Sclerosis Research Studies
- Intracranial Aneurysms: Treatment and Complications
- Biomedical Research and Pathophysiology
- Traumatic Brain Injury and Neurovascular Disturbances
- Sleep and Wakefulness Research
- Parkinson's Disease and Spinal Disorders
- Neurological disorders and treatments
University of Bologna
2015-2025
Istituto delle Scienze Neurologiche di Bologna
2018-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2024
Institute of Neurological Sciences
2018
The approval of immunotherapy has revolutionized the management hepatocellular carcinoma (HCC) patients. However, sorafenib remains a first-line therapeutic option for advanced patients and, in particular, not eligible immune checkpoint inhibitors, but its efficacy is limited by onset acquired resistance, highlighting urgent need predictive biomarkers. This study investigates role miR-22 metabolic reprogramming and potential as biomarker HCC. analysis expression was performed HCC preclinical...
Objectives The aim was to evaluate plasma and cerebrospinal fluid (CSF) nimodipine concentrations in patients with aneurysmal subarachnoid hemorrhage their correlation clinical outcome. Methods Nimodipine infusion started at 1 mg/h increased up 2 continued 21 days surviving patients. Arterial CSF samples were collected least after 24 hours of stable dosing. Delayed cerebral ischemia vasospasm documented by new neurological deficits neuroimaging. outcome assessed 9 months the modified Rankin...
Objectives We aimed to assess the potential relationship between intrasubject 9-tetrahydrocannabinol/cannabidiol (THC/CBD) oromucosal spray plasma profiles and clinical effects elicited by subacute dosing in chronically treated patients with multiple sclerosis (MS). Methods The study design was pilot, single center, open, prospective. were challenged a morning test dose of 2 THC/CBD sprays at 15-minute interval. Venous blood samples collected before first administration every 30 minutes...
We report in the present study on catalytic properties of Deinococcus radiodurans DNA polymerase III α subunit (αDr). The αDr enzyme was overexpressed Escherichia coli, both soluble form and as inclusion bodies. When purified from protein extracts, found to be tightly associated with E. coli RNA polymerase, which could not dissociated. On contrary, when refolded bodies, devoid homogeneity. assayed different substrates, featured slower extension rates compared corresponding (E. Pol III, αEc),...
Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by α-galactosidase A gene (GLA) mutations, resulting in loss of activity the hydrolase, (α-Gal A). As result, main glycosphingolipid substrates, globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-Gb3), accumulate plasma, urine, tissues. Here, we propose simple, fast, sensitive method for plasma quantification lyso-Gb3, most promising secondary screening target FD. Assisted protein precipitation with methanol...
Limited data are available in clinical settings on the pharmacokinetics of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). We investigated use cannabis-based products neurological practice, monitoring patients' steady-state cannabinoids (CBs) plasma concentrations matched with different preparations.This was a prospective, single-center, observational study. Patients underwent venous blood withdrawal before CBs' morning dose then 2.5 h post-dosing. Spasticity or pain were patient...