A5013509057- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Bariatric Surgery and Outcomes
- Obstructive Sleep Apnea Research
- Inflammatory Bowel Disease
- Sleep and related disorders
- Body Contouring and Surgery
- Microscopic Colitis
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Sleep and Wakefulness Research
- Gastroesophageal reflux and treatments
- Restless Legs Syndrome Research
- Gastrointestinal disorders and treatments
- Heart Rate Variability and Autonomic Control
- Systemic Lupus Erythematosus Research
- Neuroscience of respiration and sleep
- Neuroinflammation and Neurodegeneration Mechanisms
- Hereditary Neurological Disorders
- Epilepsy research and treatment
- Gastrointestinal Tumor Research and Treatment
- Autoimmune and Inflammatory Disorders
- Neonatal Health and Biochemistry
- Traumatic Brain Injury and Neurovascular Disturbances
University of Liverpool
2023-2025
Walton Centre
2023-2025
University of Pavia
2025
Marche Polytechnic University
2020-2023
University of Oxford
2023
Policlinico Tor Vergata
2023
Qatar Foundation
2021
University of Sassari
2015-2019
University of Rome Tor Vergata
2006-2019
Queen Mary University of London
2014
Futile recanalization remains a significant challenge for endovascular treatment (EVT) of acute ischemic stroke (AIS). The inflammatory response that occurs after cerebral infarct plays central role in pathobiology can influence the outcome procedure. aim this study was to evaluate relationship between systemic index (SIRI) and futile patients with AIS. We retrospectively identified consecutive due proximal arterial occlusion anterior circulation, who were treated EVT achieved near-complete...
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is a recently identified autoimmune demyelinating disorder of the CNS affecting both adults and children. Diagnostic criteria for MOGAD have been published. We aimed to validate 2023 diagnostic in real-world cohort patients with atypical inflammation.
Acute inflammatory CNS diseases include neuromyelitis optica spectrum disorders (NMOSDs) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Both MOGAD acute disseminated encephalomyelitis (ADEM) have been reported after vaccination. Consequently, the mass SARS-CoV-2 vaccination program could result in increased rates of these conditions. We described features patients presenting with new demyelination resembling NMOSDs or within 8 weeks vaccination.The study...
Background Ustekinumab (UST) is an interleukin-12/interleukin-23 receptor antagonist recently approved for treating ulcerative colitis (UC) but with limited real-world data. Therefore, we evaluated the effectiveness and safety of UST in patients UC a setting.
Objectives: The study aimed to explore the clinical predictors of pharmaco-resistance in patients with post-stroke epilepsy (PSE). Methods: Patients secondary cerebral infarct or spontaneous intracerebral hemorrhage were included. outcome was occurrence defined as failure adequate trials two tolerated and appropriately chosen used antiseizure medication schedules, whether monotherapies combination, achieve sustained seizure freedom. Results: One-hundred fifty-nine PSE a median follow-up 5...
Transforming growth factor-beta (TGF-β) is deeply involved in colorectal cancer development and the disruption of TGF-β signaling dysplastic cells required for tumor to grow. Nevertheless, express escape immune surveillance mediated by T cells. T-cell expression Smad7, an intracellular inhibitor signaling, protects against colitis-associated cancer. However, whether Smad7 might influence independently chronic inflammation which subset this process unknown. To address issue, T-cell-specific...
Studies in MS and NMOSD have shown that relapses can frequently occur the same location as first attack. Factors associated with this outcome MOGAD are unclear. The objective of study was to investigate likelihood a relapse occurring at site MOGAD. This UK national cohort study. patients minimum one year follow-up were included. To identify factors location, logistic regression performed. An increased risk observed when attack optic neuritis-for second (OR 12.9, 95% CI 3.31-50.55, p = .001)...
ABSTRACT Background Most patients with aquaporin‐4 antibody‐positive neuromyelitis optica spectrum disorder (AQP4‐IgG NMOSD) require life‐long immunosuppression to prevent relapses. Patients who are untreated or undergo de‐escalation of therapy typically experience severe disabling We present a series who, despite not receiving immunosuppression, developed minimal disability. Methods Case from UK national NMOSD referral centre. defined benign disease as an estimated disability status scale...
To perform a clinical and genetic study of two large Italian families (RM-36 RM-51) showing the cardinal features Silver syndrome (SS), rare dominantly inherited form hereditary spastic paraplegia (HSP) complicated by amyotrophy small hand muscles.Clinical assessment including neurophysiologic, neuropsychological, neuroimaging evaluations. Genetic studies included linkage sequence analyses.Using genome-wide survey in RM-36 family, novel locus (SPG38) has been identified mapped within 13.1-cM...
Some evidence suggests a possible influence of liver disease on stroke prognosis. We investigated the association between fibrosis-4 (FIB-4) score, marker disease, and 3-month outcome in patients with ischemic undergoing intravenous thrombolysis. also evaluated rate symptomatic intracranial hemorrhage after In this prospective cohort study, we enrolled consecutive treated thrombolysis who had follow-up. The FIB-4 score was calculated validated cut-off values were used to indicate high/low...
Background: Predictive markers of cardiac side effects would be helpful for the stratification and individualized monitoring multiple sclerosis (MS) patients prescribed with fingolimod. Objective: To test whether autonomic balance predicts a response after first dose Methods: A total 55 consecutive relapsing–remitting MS (RRMS) underwent ‘head-up tilt’, Valsalva maneuver, deep breathing handgrip tests before their The normalized unit high frequency (HF) component (HF units; HFnu), reflecting...
Background: Isolated first episodes of longitudinally extensive transverse myelitis (LETM) have typically been associated with neuromyelitis optica spectrum disorder (NMOSD) or myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD). However, in some cases, serological testing and screening for other aetiologies are negative, a condition referred to as double seronegative (dsLETM). Objective: The objective this study was evaluate comparative outcomes dsLETM, MOGAD-LETM...
Background: Acute optic neuritis is often in association with multiple sclerosis (MS). Proinflammatory cytokines trigger neuronal damage neuroinflammatory disorders but their role poorly investigated. Objective: The objective of this work to investigate the associations intrathecal contents proinflammatory transient and persistent dysfunctions after neuritis. Methods: In 50 MS patients followed for up six months, cerebrospinal fluid (CSF) levels IL-1β, TNF IL-8 were determined, along...
Clinical studies have shown that bismuth-containing quadruple therapy given twice a day for 10 to 14 days is effective and safe in the treatment of Helicobacter pylori infection Sardinia. However, bismuth no longer available Italy. To report effectiveness tolerability pantoprazole 20 mg, tetracycline 500 metronidazole mg b.i.d. (with midday evening meals) supplemented with Lactobacillus reuteri (DSM 17938) 108 cfu/tablet once patients treated routine daily practice setting. H was defined as...