Paolo Usai–Satta
A5087628660- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Digestive system and related health
- Gastroesophageal reflux and treatments
- Celiac Disease Research and Management
- Inflammatory Bowel Disease
- Microscopic Colitis
- Diet and metabolism studies
- Congenital gastrointestinal and neural anomalies
- Eosinophilic Esophagitis
- Diet, Metabolism, and Disease
- Esophageal and GI Pathology
- Diverticular Disease and Complications
- Pelvic floor disorders treatments
- Microbial Metabolites in Food Biotechnology
- Nutrition, Genetics, and Disease
- Esophageal Cancer Research and Treatment
- Anorectal Disease Treatments and Outcomes
- Gastrointestinal disorders and treatments
- Biochemical and Molecular Research
- Biosimilars and Bioanalytical Methods
- Colorectal Cancer Screening and Detection
- Infant Nutrition and Health
- Infant Health and Development
- Gastric Cancer Management and Outcomes
Azienda Ospedaliera G. Brotzu
2016-2025
Ospedale L. Bonomo
2024
University of Pisa
2014-2015
University of Cagliari
1995-1997
Abstract Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS independent cohorts. conducted genome-wide association study 53,400 433,201 controls replicated significant associations in 23andMe panel (205,252 1,384,055 controls). Our confirmed six genetic loci IBS. Implicated...
IBS is a common gut disorder of uncertain pathogenesis. Among other factors, genetics and certain foods are proposed to contribute. Congenital sucrase-isomaltase deficiency (CSID) rare genetic form disaccharide malabsorption characterised by diarrhoea, abdominal pain bloating, which features IBS. We tested (SI) gene variants for their potential relevance in IBS.We sequenced SI exons seven familial cases, screened four CSID mutations (p.Val557Gly, p.Gly1073Asp, p.Arg1124Ter p.Phe1745Cys)...
Lactose malabsorption (LM) is the incomplete hydrolysis of lactose due to lactase deficiency, which may occur as a primary disorder or secondary other intestinal diseases. Primary adult-type hypolactasia an autosomal recessive condition resulting from physiological decline activity. Different methods have been used diagnose LM. breath test represents most reliable technique. A recent consensus conference has proposed more dosage 25 g and standardized procedure for testing. Recently new...
Patients with irritable bowel syndrome (IBS) often associate their symptoms to certain foods. In congenital sucrase-isomaltase deficiency (CSID), recessive mutations in the SI gene (coding for disaccharidase digesting sucrose and 60% of dietary starch)1 cause clinical features IBS through colonic accumulation undigested carbohydrates, triggering symptoms.2 Hence, a previous study,3 we hypothesized that CSID variants reducing enzymatic activity may contribute development symptoms. We detected...
Background Ustekinumab (UST) is an interleukin-12/interleukin-23 receptor antagonist recently approved for treating ulcerative colitis (UC) but with limited real-world data. Therefore, we evaluated the effectiveness and safety of UST in patients UC a setting.
According to Rome criteria, chronic constipation (CC) includes functional (FC) and irritable bowel syndrome with (IBS-C). Some patients do not meet these criteria (No Constipation, NRC). The aim of the study was is evaluate various clinical presentation management FC, IBS-C NRC in Italy. During a 2-month period, 52 Italian gastroenterologists recorded data patients, using Bristol scale, PAC-SYM PAC-QoL questionnaires. In addition, were also asked record whether clinically assessed for CC...
Coeliac disease (CD) is an autoimmune disorder of the small bowel associated with increased risk additional diseases (ADs). To investigate prevalence ADs in a population adult coeliac patients. This was retrospective case–control study. Data from patients and controls referred to tertiary center between 2013 2016 were collected. The frequency unadjusted adjusted odds ratios (ORs) for age, gender, duration, body mass index their 95% confidence intervals (CIs) evaluated. Two hundred fifty-five...
Abstract Background Upadacitinib (UPA), a selective anti-JAK1, has obtained refundability from the Italian National Health System in July 2023 for its use patients with Ulcerative Colitis (UC) refractory to other therapies, including anti-TNF-α, anti-integrins and ustekinumab. At present, no data are available yet about effectiveness safety Real World. Methods A retrospective assessment of clinical endoscopic activity was performed according Mayo score. The primary endpoints were evaluate...
Abstract Background Filgotinib (FILGO), a selective anti-JAK1, has obtained refundability from the Italian National Health System in February 2023 for its use patients with Ulcerative Colitis (UC) refractory to other therapies, including anti-TNF-α, anti-integrins and ustekinumab. At present, no data are available yet about effectiveness safety Real World. Methods A retrospective assessment of clinical endoscopic activity was performed according Mayo score. The primary endpoints were...
There is recent evidence that upper‐gut motor abnormalities may be present in coeliac disease. However, to date, the pathophysiological mechanisms responsible for above have not been explored. The purpose of study was investigate activity disease and explore role played by autonomic nervous system motility disturbances. Thirty untreated adult patients were recruited into study. Oesophageal manometry cardiovascular tests performed all patients; oesophageal pH‐metry carried out 20 patients,...
Introduction: Chronic constipation (CC) is a common gastrointestinal disorder with limited treatment options. Linaclotide potent peptide agonist of the guanylate cyclase-C receptor. This action activates intracellular conversion guanosine 5-triphosphate to cyclic monophosphate resulting in stimulation intestinal fluid secretion. promising new agent for refractory constipation.Areas covered: All published articles regarding development, clinical efficacy, and safety linaclotide treating CC...
Inflammatory bowel diseases, comprising Crohn’s disease (CD) and ulcerative colitis (UC), are chronic, relapsing, remitting immune-mediated inflammatory diseases affecting the gastrointestinal tract. Ustekinumab (UST) is a monoclonal antibody that blocks p40 subunit of anti-interleukin (IL) 12/23. Pivotal trials (CERTIFI UNITI-IM for CD, UNIFI UC) established efficacy UST induction maintenance remission in both CD UC, with most favorable results naïve patients to biologics. In recent years,...