A5046557438- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- Congenital gastrointestinal and neural anomalies
- Gastrointestinal disorders and treatments
- Diverticular Disease and Complications
- Esophageal Cancer Research and Treatment
- Angiogenesis and VEGF in Cancer
- Pelvic floor disorders treatments
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Dysphagia Assessment and Management
- Cell Adhesion Molecules Research
- Intestinal Malrotation and Obstruction Disorders
- Music Therapy and Health
- Colorectal Cancer Screening and Detection
- Platelet Disorders and Treatments
- Lipid metabolism and disorders
- Gut microbiota and health
- Protease and Inhibitor Mechanisms
- Intestinal and Peritoneal Adhesions
- Gastrointestinal Bleeding Diagnosis and Treatment
- Liver Diseases and Immunity
Ospedale Civile Di Ivrea
2024
Azienda Sanitaria Locale di Asti
2009-2020
Ospedale Garibaldi
2015-2016
Laboratoire Interdisciplinaire des Environnements Continentaux
2015
Azienda Ospedaliera Pugliese Ciaccio
2011
University of Perugia
1998-2007
University of Turin
1994-2006
Azienda Ospedaliero Universitaria San Giovanni Battista
2005
Fondazione Ricerca Molinette
2004
Ospedale Humanitas Gradenigo
2000
Colonic diverticular disease (diverticulosis) is a common disorder in Western countries. Although its pathogenesis probably multifactorial, motor abnormalities of the large bowel are thought to play an important role. However, little known about basic mechanism that may underlie abnormal colon motility diverticulosis.To investigate interstitial cells Cajal (the gut pacemaker cells), together with myenteric and submucosal ganglion glial cells, patients diverticulosis.Full thickness colonic...
Tumor necrosis factor (TNF) alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic vivo. Therefore, it was suggested that the properties this agent might be consequent to production secondary mediators. Since TNF-alpha stimulates synthesis platelet-activating (PAF) by monocytes and cells, we investigated possible involvement PAF effect TNF-alpha. Angiogenesis studied murine model which Matrigel used as vehicle for delivery In angiogenesis induced shown inhibited WEB...
Diverticular disease of the colon is one most common pathologic entities in western countries. Although altered motility large bowel commonly believed to be major pathophysiologic mechanisms, no convincing evidence has been reported yet. In fact, only a few conflicting studies concerning distal colonic (with information on forceful propulsive activity) are available literature.The purpose present study was investigate basal and stimulated (postprandial) from transverse (not affected),...
PURPOSE: Biofeedback training has been shown as an effective therapeutic measure in patients with pelvic floor dyssynergia, at least the short term. Long-term effects have received less attention. Moreover, its slow-transit constipation scarcely investigated. This study was designed to assess objective way medium- and long-term of biofeedback muscle dyssynergia constipation. METHODS: Twenty-four (14 10 slow transit) meeting Rome II criteria for constipation, unresponsive conventional...
The aim of the present study was to evaluate immunological effects on human macrophages four endocrine disruptor compounds (EDCs) using differentiated THP-1 cell line as a model. We studied first these EDCs, including Bisphenol A (BPA), di-ethylhexyl-phthalate (DEHP), dibutyl phthalate (DBP) and 4-tert-octylphenol (4-OP), either alone or in combination, cytokine secretion, phagocytosis. then determined whether not were mediated by estrogen receptors via MAPK pathways. It found that all EDCs...
According to Rome criteria, chronic constipation (CC) includes functional (FC) and irritable bowel syndrome with (IBS-C). Some patients do not meet these criteria (No Constipation, NRC). The aim of the study was is evaluate various clinical presentation management FC, IBS-C NRC in Italy. During a 2-month period, 52 Italian gastroenterologists recorded data patients, using Bristol scale, PAC-SYM PAC-QoL questionnaires. In addition, were also asked record whether clinically assessed for CC...
Abstract —In this study, we demonstrate that human umbilical cord vein–derived endothelial cells (HUVECs) expressed c-Mpl, the thrombopoietin (TPO) receptor, and TPO activates HUVECs in vitro, as indicated by directional migration, synthesis of 1-alkyl-/1-acyl-platelet-activating factor (PAF) interleukin-8 (IL-8), phosphorylation signal transducers activators transcription (STAT) STAT1 STAT5B. The observation WEB 2170 CV3988, 2 structurally unrelated PAF receptor antagonists, prevented...
To investigate the relationship between esophageal function and extent of disease in a nonselected group scleroderma patients, to study gastric small bowel motility patients with more severe clinical manifestations.Esophageal 125 was investigated by radiologic, endoscopic, manometric, pH-metric techniques. Ten also underwent gastrointestinal (GI) manometric recording, both during fasting after standard meal.Radiologic abnormalities esophagus were found 55 81 (68%) esophagitis 45 (36%). No...
Abstract The aim of the present study was to investigate in vivo a mouse model stimulation neoangiogenesis by synovial fluids patients with rheumatoid arthritis (RA) and determine role tumor necrosis factor (TNF)‐α platelet‐activating (PAF) formation new vessels. Angiogenesis studied which Matrigel, injected subcutaneously, used as vehicle for delivery potential angiogenic stimuli. Synovial RA but not osteoarthritis (OA) were shown induce neoangiogenesis. Since fluid contained significantly...
Objective: Selected mechanisms of the immune system participate in development inflammatory bowel disease. Recently, overexpression ligand for CD40 (CD40L), a lymphocyte costimulatory molecule, was shown to induce severe disease transgenic mice. In present study, we examined expression and CD40L on surgical specimens ileum from 12 patients with Crohn's 10 diverticulitis. Methods: Several CD40L+ cells were affected tissue disease, whereas few scattered detected sections histologically normal...
Chronic constipation is a frequent symptom among the general population, and minority of cases do not respond to any therapeutic measures, except surgery. The purpose this study was test residual colonic motor propulsive activity with pharmacologic stimulus in series patients referred for severe constipation.Twenty-five chronically constipated patients, slow transit type, age range 16-71 years, unresponsive conventional medical treatment functional evaluation, entered study.Colonic manometry...
Abstract —We previously reported that platelet-activating factor (PAF) enhances the angiogenic activity of certain polypeptide mediators such as tumor necrosis and hepatocyte growth by promoting endothelial cell motility. The purpose present study was to evaluate whether synthesis PAF induced vascular (VEGF) might affect motility, microvascular permeability, angiogenesis. neoangiogenesis VEGF were studied in vivo a murine Matrigel model. Dermal permeability mice injection 125 I-albumin. PAF,...