A5086808460- Peripheral Neuropathies and Disorders
- Multiple Sclerosis Research Studies
- Autoimmune Neurological Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Myasthenia Gravis and Thymoma
- Polyomavirus and related diseases
- Amyotrophic Lateral Sclerosis Research
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA regulation and disease
- Cancer Immunotherapy and Biomarkers
- Hereditary Neurological Disorders
- Neurological and metabolic disorders
- CNS Lymphoma Diagnosis and Treatment
- Alcoholism and Thiamine Deficiency
- Glioma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Brain Metastases and Treatment
- Spinal Dysraphism and Malformations
- Folate and B Vitamins Research
- IgG4-Related and Inflammatory Diseases
- Neurogenetic and Muscular Disorders Research
- Cerebrovascular and genetic disorders
- Infectious Diseases and Tuberculosis
- Sarcoidosis and Beryllium Toxicity Research
- Peripheral Nerve Disorders
University of Sassari
2016-2025
Mayo Clinic
2016-2024
Mayo Clinic in Florida
2020-2024
University of Verona
2020-2024
Mayo Clinic in Arizona
2018-2024
University of Cagliari
2022-2024
University of Florence
2024
WinnMed
2019-2023
Vita-Salute San Raffaele University
2022-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2022-2023
<h3>Importance</h3> Recognizing the characteristics of myelin oligodendrocyte glycoprotein autoantibody (MOG-IgG) myelitis is essential for early accurate diagnosis and treatment. <h3>Objective</h3> To evaluate clinical, radiologic, prognostic features MOG-IgG compare with aquaporin-4–IgG (AQP4-IgG) multiple sclerosis (MS). <h3>Design, Setting, Participants</h3> We retrospectively identified 199 MOG-IgG–positive Mayo Clinic patients from January 1, 2000, through December 31, 2017, our...
<h3>Importance</h3> Myelin oligodendrocyte glycoprotein-IgG1–associated disorder (MOGAD) is a distinct central nervous system–demyelinating disease. Positive results on MOG-IgG1 testing by live cell-based assays can confirm MOGAD diagnosis, but false-positive may occur. <h3>Objective</h3> To determine the positive predictive value (PPV) of in tertiary referral center. <h3>Design, Setting, and Participants</h3> This diagnostic study was conducted over 2 years, from January 1, 2018, through...
To determine clinical manifestations, immunotherapy responsiveness and outcomes of glutamic acid decarboxylase-65 (GAD65) neurological autoimmunity. We identified 323 Mayo Clinic patients with high-titre (>20 nmol/L in serum) GAD65 antibodies out 380 514 submitted anti-GAD65 samples (2003-2018). Patients classified as having autoimmunity after chart review were analysed to disease predictors poor outcome (modified Rankin score >2). On review, 108 not 3 had no more likely alternative...
<h3>Background and Objective</h3> There are few studies comparing lesion evolution across different CNS demyelinating diseases, yet knowledge of this may be important for diagnosis understanding differences in disease pathogenesis. We sought to compare MRI T2 myelin oligodendrocyte glycoprotein immunoglobulin G (IgG)–associated disorder (MOGAD), aquaporin 4 IgG–positive neuromyelitis optica spectrum (AQP4-IgG-NMOSD), multiple sclerosis (MS). <h3>Methods</h3> In descriptive study, we...
Anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) recently emerged as a potential biomarker in patients with inflammatory demyelinating diseases of the central nervous system. We here compare clinical and laboratory findings observed cohort MOG-Ab seropositive seronegative cases describe IgG subclass analysis results. Consecutive serum samples referred to Verona University Neuropathology Laboratory for aquaporin-4 (AQP4)-Ab and/or testing were analysed between March 2014 May 2017....
<h3>Objective</h3> To describe neural autoantibody profiles and outcomes in patients with neurologic autoimmunity associated immune checkpoint inhibitor (ICI) cancer immunotherapy. <h3>Methods</h3> In this retrospective descriptive study, 63 ICI-related were included: 39 seen at the Mayo Clinic Neurology Department (clinical cohort) 24 whose serum/CSF was referred to Neuroimmunology Laboratory for testing. Serum/CSF samples tested neural-specific autoantibodies. Predictors of unfavorable...
To determine the frequency and characteristics of brainstem or cerebellar involvement in myelin-oligodendrocyte-glycoprotein-antibody-associated-disorder (MOGAD) versus aquaporin-4-IgG-seropositive-neuromyelitis optica spectrum disorder (AQP4-IgG-NMOSD) multiple sclerosis (MS).
Background: Myelitis accompanied by a negative spinal cord MRI may lead to diagnostic uncertainty. Objective and Methods: We retrospectively investigated the frequency of (performed <6 weeks from onset) in Mayo Clinic patients with myelin oligodendrocyte glycoprotein (MOG)-IgG-associated myelitis (2000–2019). Results: The initial was 7/73 (10%) patients, despite severe acute disability (median EDSS, 7 (range, 4.5–8)); symptoms/signs were frequent (paraparesis, neurogenic bladder, sensory...
To compare acute treatment responses and long-term outcome in leucine-rich glioma-inactivated 1 (LGI1) antibody encephalitis.Retrospective case series of 118 patients with LGI1 encephalitis evaluated at Mayo Clinic across all US sites from May 2008 to 31 March 2019. Patient clinical data were identified analysed through the neuroimmunology laboratory electronic medical record. detection was by cell-based indirect immunofluorescence assay serum, cerebrospinal fluid or both. Clinical outcomes...
This cohort study reports outcomes of long-term follow-up in patients with myelin oligodendrocyte glycoprotein antibody–associated disorder.
Although the diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is based on serum MOG antibodies (MOG-Abs) positivity, patients with coexisting or restricted MOG-Abs in CSF have been reported. The aim this study to characterize relevance positivity clinical practice.Eleven medical centers retrospectively collected and laboratory data adult pediatric suspected inflammatory CNS and/or using live cell-based assays. Comparisons were performed parametric...
Cerebral cortical encephalitis (CCE) is a recently described myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) phenotype. In this observational retrospective study, we characterized 19 CCE patients (6.7% of our MOGAD cohort). Headache (n = 15, 79%), seizures 13, 68%), and encephalopathy 12, 63%) were frequent. Magnetic resonance imaging revealed unilateral or bilateral 7, 37%) T2 hyperintensity leptomeningeal enhancement 17, 89%). N‐Methyl‐D‐aspartate receptor...
Studies on tumefactive brain lesions in myelin oligodendrocyte glycoprotein-immunoglobulin G (IgG)-associated disease (MOGAD) are lacking. We sought to characterize the frequency clinical, laboratory, and MRI features of these MOGAD compare them with those multiple sclerosis (MS) aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD).We retrospectively searched 194 patients 359 AQP4+NMOSD clinical/MRI details available from Mayo Clinic databases included ≥1 lesion...
Outcome and rechallenge data on central nervous system (CNS) autoimmunity triggered by immune checkpoint inhibitors (ICIs) are limited. We aim to describe a large series of patients with ICI-triggered CNS autoimmunity, compare these spontaneous paraneoplastic syndromes (PNS).We retrospectively reviewed Mayo Clinic (February 2015-June 2021). Clinical characteristics were compared PNS (with antineuronal nuclear antibody [ANNA]-1 or anti-Hu neurological and/or neuroendocrine tumors [NET])...
Introduction Limited data exist on brain MRI enhancement in myelin-oligodendrocyte-glycoprotein (MOG) antibody-associated disease (MOGAD) and differences from aquaporin-4-IgG-positive-neuromyelitis-optica-spectrum-disorder (AQP4+NMOSD), multiple sclerosis (MS). Methods In this retrospective observational study, we identified 122 Mayo Clinic MOGAD patients (1 January 1996–1 July 2020) with cerebral attacks. We explored patterns using a discovery set (n=41). assessed frequency Expanded...
The lateral femoral cutaneous nerve (LFCN) is a branch of the lumbar plexus and supplies skin thigh region. This entrapment-compressive syndrome named meralgia paresthetica or Roth's depends, on vast majority cases, entrapment in proximity inguinal ligament. Surgical decompression an option when conservative treatments fail usually performed through 3-cm infrainguinal incision. Available data anatomical variations LFCN derive from extensive cadaver dissections lack many features relevant to...