A5080779706- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Ocular Diseases and Behçet’s Syndrome
- Trigeminal Neuralgia and Treatments
- Migraine and Headache Studies
- Autoimmune Neurological Disorders and Treatments
- Reproductive System and Pregnancy
- Hereditary Neurological Disorders
- Parkinson's Disease and Spinal Disorders
- Pathogenesis and Treatment of Hiccups
- Ophthalmology and Eye Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Myasthenia Gravis and Thymoma
- Multiple Myeloma Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Endometriosis Research and Treatment
- Cytokine Signaling Pathways and Interactions
- Immunotoxicology and immune responses
- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cell Adhesion Molecules Research
- Anesthesia and Pain Management
McMaster University
2022-2024
Hamilton Health Sciences
2022
King Hamad University Hospital
2022
Arabian Gulf University
2022
Ministry of Health
2022
King Khaled Hospital
2020
Riyadh Armed Forces Hospital
2019-2020
Western University
2019-2020
Mayo Clinic
2017-2019
Majmaah University
2017-2019
<h3>Importance</h3> Recognizing the characteristics of myelin oligodendrocyte glycoprotein autoantibody (MOG-IgG) myelitis is essential for early accurate diagnosis and treatment. <h3>Objective</h3> To evaluate clinical, radiologic, prognostic features MOG-IgG compare with aquaporin-4–IgG (AQP4-IgG) multiple sclerosis (MS). <h3>Design, Setting, Participants</h3> We retrospectively identified 199 MOG-IgG–positive Mayo Clinic patients from January 1, 2000, through December 31, 2017, our...
<h3>Objective</h3> To define the frequency, duration, and severity of intractable nausea, vomiting, or hiccups in aquaporin-4–immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica spectrum disorder (NMOSD) propose diagnostic criteria a scale for area postrema syndrome (APS). <h3>Methods</h3> An International NMOSD database was interrogated frequency APS. Patients with AQP4-IgG–positive completed an APS symptom questionnaire. Nausea vomiting derived from Pregnancy-Unique Quantification...
Transnasal sphenopalatine ganglion block is emerging as an attractive and effective treatment modality for acute migraine headaches, cluster headache, trigeminal neuralgia, several other conditions. We assessed the efficacy safety of this using Sphenocath® device. 55 patients with headaches underwent procedure, receiving 2 ml 2% lidocaine in each nostril. Pain numeric rating scale (baseline, 15 minutes, hours, 24 hours) patient global impression change (2 hours after treatment) were...
Abstract Background: Cerebrospinal fluid (CSF) used in immunoglobulin gamma (IgG) index testing and oligoclonal bands (OCBs) are common laboratory tests the diagnosis of multiple sclerosis. The measurement CSF free light chains (FLC) could pose as an alternative to labor-intensive isoelectric-focusing (IEF) gels for OCBs. Methods: A total 325 residual paired serum specimens were obtained after physician-ordered OCB IEF testing. kappa (cKFLC) lambda FLC (cLFLC), albumin IgG measured....
<h3>Objective</h3> Diagnostic criteria from 2002 classify transverse myelitis (TM) as idiopathic or disease associated but predate the discovery of aquaporin-4 (AQP4)–immunoglobulin G (IgG) and myelin oligodendrocyte glycoprotein (MOG)-IgG, which associate with TM. Prior incidence estimates TM (ITM) range 1 to 6.2 per million. We sought determine whether population-based prevalence ITM were reduced by testing patients for AQP4/MOG-IgG reclassifying seropositive cases having...
Introduction: Myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG)-related disease was initially described as a subtype of neuromyelitis optica spectrum disorder (NMOSD) with antibodies against MOG. However, it has recently been separate entity clinical and radiological features that overlap those multiple sclerosis (MS) NMOSD; the this phenotype remain undetermined. We herein report presentation nine MOG-IgG-positive patients, not all whom fulfill NMOSD criteria, in order to...
Abstract Background and purpose Blood pressure (BP) changes during alemtuzumab infusions are poorly understood. The aim of this study was to examine BP in persons with multiple sclerosis (PwMS). Methods This a retrospective cohort review systolic (S) diastolic (D) PwMS receiving alemtuzumab. Results Thirty‐one patients were identified; 22 (64.5%) women. Mean age disease duration 35.2 ± 7.1 9.2 5.4 years, respectively. There no history hypertension or vascular events. baseline SBP 119.8 15.1...
Neuromyelitis optica spectrum disorders (NMOSD) have been studied in different ethnic groups, including Asians, African-Americans, and Caucasians. Demonstrating the clinical features among diverse communities is important to understand variable disease phenotypes, which will lead further classification better management. Testing for antibody against aquaporin-4 (AQP4), most common target antigen NMOSD, not available many countries tests use methods, with sensitivity. With negative results,...
For the past 10 years, disease-modifying therapy (DMT) options for multiple sclerosis (MS) have grown remarkably where DMTs been shown to reduce risk of MS relapses. patients are advised begin treatment with a DMT shortly after diagnosis limit possibility disease progression over time. While radiologically isolated syndrome do not require pharmacologic treatment, high-risk clinically start DMTs. This article provides evidence-based recommendations use in management, helping healthcare...
Limb-girdle muscular dystrophies (LGMD) is a heterogeneous group of genetic disorders characterized by progressive weakness pelvic and shoulder girdle muscles. The objective to characterize the phenotypic, pathological, radiological, findings in LGMD2A phenotype (Calpainopathies).The National Saudi Arabian LGMD cohort database was screened for from January 2000 2021. A descriptive cross-sectional study done on total 112 families with LGMD. Screening mutation Calpain (CAPN3) gene done....
Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a recently emerging autoimmune disease of the central nervous system (CNS); GFAP characterized by optic neuritis and meningoencephalomyelitis. We report case 55-year-old man, otherwise healthy, who presented with isolated headaches for three months, without other features meningoencephalitis or myelitis. His neurological examination fundoscopy were unremarkable. Gadolinium-enhanced brain MRI demonstrated increased T2...
Multiple sclerosis (MS) is an inflammatory neurological illness common in young adults. The prevalence and incidence of MS are regionally globally increasing. Recent data from Saudi Arabia (SA) estimate the to be 40.40 cases per 100,000 population, 61.95 population for nationals. With increasing availability treatment options, new challenges selection approaches have emerged. There a clear need national guidelines standardize practice, guide personalization decisions, contain costs. A...
This article deals with recommendations on the management of symptoms MS and provision vaccinations in patients receiving disease-modifying therapies (DMTs). Symptoms MS, such as fatigue, depression, urinary symptoms, spasticity, impairment gait, sexual dysfunction, are common this population. Recognizing addressing these is key to maintaining quality life people MS. Vaccination status should be reviewed updated prior initiation DMTs. In general, vaccination avoided for variable periods...
This review article addresses the complex issues faced by individuals with Multiple Sclerosis (MS) who are planning a family, becoming pregnant, or wishing to breastfeed their baby. Recommendations and guidelines were discussed agreed upon neurologists, neuroradiologists, nurses, pharmacists involved in management of MS Kingdom Saudi Arabia (KSA). itself does not harm pregnancy, people childbearing age can be encouraged enjoy family life. Family should part initial conversation newly...
Objective: To define the frequency, duration and severity of intractable nausea, vomiting or hiccups (INVH) in NMOSD Background: INVH are symptoms inflammation targeted to AQP4-expressing astrocytes AP. Published data relating duration, lacking. Design/Methods: Of 541 patients with AQP4-IgG-positive Mayo Clinic’s database, 200 reported at some point. date, 52 a history have been surveyed by telephone. Results: occurred first attack 26 (50%) patients. All 3 (NVH) were present 31 patients, 2...
To report demographic and clinical data on 98 myasthenia gravis (MG) patients, seen over 5 years (January 2014-December 2018).This was a retrospective, observational cohort study carried out at 3 hospitals in Bahrain. MG classified into ocular or generalized types. We subdivided early-onset (EOMG, ≤ 49 years) late-onset (LOMG, > years). Demographic were recorded. The entered analyzed using SPSS version 26.0.61.2% females. mean age onset 43.8±17.7 males 43.1±15.7 72.4% had EOMG. A pure...