Esther L. Yuh
A5044174824- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- S100 Proteins and Annexins
- Advanced Neuroimaging Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Advanced MRI Techniques and Applications
- Sepsis Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Spinal Fractures and Fixation Techniques
- Medical Imaging Techniques and Applications
- Ultrasound Imaging and Elastography
- Neurosurgical Procedures and Complications
- Radiation Dose and Imaging
- Medical Imaging and Analysis
- Photoacoustic and Ultrasonic Imaging
- Brain Tumor Detection and Classification
- Multimodal Machine Learning Applications
- Domain Adaptation and Few-Shot Learning
- Hip and Femur Fractures
- Cardiac, Anesthesia and Surgical Outcomes
- Neurofibromatosis and Schwannoma Cases
- Glioma Diagnosis and Treatment
University of California, San Francisco
2016-2025
University of California System
2015-2024
San Francisco General Hospital
2015-2024
Mary Ann Liebert (United States)
2024
Antwerp University Hospital
2022
University of Antwerp
2022
Neurological Surgery
2014-2022
University of Washington
2022
Human Longevity (United States)
2022
University of California, San Diego
2022
Mild Traumatic Brain Injury (mTBI), or concussion, is a major public health concern. There controversy in the literature regarding true incidence of postconcussion syndrome (PCS), with constellation physical, cognitive, emotional, and sleep symptoms after mTBI. In current study, we report on evolution PCS patient outcomes mTBI at 3, 6, 12 months large, prospective cohort patients. Participants were identified as part prospective, multi-center Transforming Research Clinical Knowledge Study....
Biomarkers are important for accurate diagnosis of complex disorders such as traumatic brain injury (TBI). For a and multifaceted condition TBI, it is likely that single biomarker will not reflect the full spectrum response tissue to injury. Ubiquitin C-terminal hydrolase L1 (UCH-L1) glial fibrillary acidic protein (GFAP) among most widely studied biomarkers TBI. Because UCH-L1 GFAP measure distinct molecular events, we hypothesized analysis both would be superior each alone prognosis Serum...
To determine the clinical relevance, if any, of traumatic intracranial findings on early head computed tomography (CT) and brain magnetic resonance imaging (MRI) to 3-month outcome in mild injury (MTBI).One hundred thirty-five MTBI patients evaluated for acute emergency departments 3 LEVEL I trauma centers were enrolled prospectively. In addition admission CT, MRI was performed 12 ± 3.9 days after injury. Univariate multivariate logistic regression used assess demographic, clinical,...
Most traumatic brain injuries (TBIs) are classified as mild (mTBI) based on admission Glasgow Coma Scale (GCS) scores of 13 to 15. The prevalence persistent functional limitations for these patients is unclear.To characterize the natural history recovery daily function following mTBI vs peripheral orthopedic injury in first 12 months postinjury using data from Transforming Research and Clinical Knowledge Traumatic Brain Injury (TRACK-TBI) study, and, clinical computed tomographic (CT) scans,...
Traumatic brain injury (TBI) is among the leading causes of death and disability worldwide, with enormous negative social economic impacts. The heterogeneity TBI combined lack precise outcome measures have been central to discouraging results from clinical trials. Current approaches characterization disease severity not changed in more than three decades. This prospective multicenter observational pilot study aimed validate feasibility implementing Common Data Elements (TBI-CDEs). A total...
Significance Computed tomography (CT) of the head is workhorse medical imaging modality used worldwide to diagnose neurologic emergencies. However, these gray scale images are limited by low signal-to-noise, poor contrast, and a high incidence image artifacts. A unique challenge identify tiny subtle abnormalities in large 3D volume with near-perfect sensitivity. We single-stage, end-to-end, fully convolutional neural network achieve accuracy levels comparable that highly trained...
<h3>Importance</h3> Traumatic brain injury (TBI) has been associated with adverse mental health outcomes, such as posttraumatic stress disorder (PTSD) and major depressive (MDD), but little is known about factors that modify risk for these psychiatric sequelae, particularly in the civilian sector. <h3>Objective</h3> To ascertain prevalence of PTSD MDD among patients evaluated emergency department mild TBI (mTBI). <h3>Design, Setting, Participants</h3> Prospective longitudinal cohort study...
<h3>Importance</h3> Annually in the United States, at least 3.5 million people seek medical attention for traumatic brain injury (TBI). The development of therapies TBI is limited by absence diagnostic and prognostic biomarkers. Microtubule-associated protein tau an axonal phosphoprotein. To date, presence hypophosphorylated (P-tau) plasma from patients with acute chronic has not been investigated. <h3>Objective</h3> examine associations between P-tau total-tau (T-tau) levels presence,...
We evaluated 3T diffusion tensor imaging (DTI) for white matter injury in 76 adult mild traumatic brain (mTBI) patients at the semiacute stage (11.2±3.3 days), employing both whole-brain voxel-wise and region-of-interest (ROI) approaches. The subgroup of 32 with any intracranial lesion on either day-of-injury computed tomography (CT) or magnetic resonance (MRI) demonstrated reduced fractional anisotropy (FA) numerous tracts, compared to 50 control subjects. In contrast, 44 CT/MRI-negative...
<h3>Importance</h3> Moderate to severe traumatic brain injury (msTBI) is a major cause of death and disability in the US worldwide. Few studies have enabled prospective, longitudinal outcome data collection from acute chronic phases recovery after msTBI. <h3>Objective</h3> To prospectively assess outcomes areas life function at 2 weeks 3, 6, 12 months <h3>Design, Setting, Participants</h3> This cohort study, as part Transforming Research Clinical Knowledge TBI (TRACK-TBI) was conducted 18...
We report white matter changes after mild traumatic brain injury and their relationship with self-reported cognitive symptoms.
The prognostic value of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) as day-of-injury predictors functional outcome after traumatic brain injury is not well understood. GFAP a found in cells UCH-L1 neurons, these biomarkers have been cleared to aid decision making regarding whether CT should be performed injury. We aimed quantify their accuracy investigate contribute novel information existing clinical models.
<h3>Importance</h3> Knowledge of differences in mild traumatic brain injury (mTBI) recovery by sex and age may inform individualized treatment these patients. <h3>Objective</h3> To identify sex-related symptom from mTBI; secondarily, to explore within women, who demonstrate poorer outcomes after TBI. <h3>Design, Setting, Participants</h3> The prospective cohort study Transforming Research Clinical Traumatic Brain Injury (TRACK-TBI) recruited 2000 patients with mTBI February 26, 2014, July 3,...
Reliable diagnosis of traumatic brain injury (TBI) is a major public health need. Glial fibrillary acidic protein (GFAP) expressed in the central nervous system, and breakdown products (GFAP-BDP) are released following parenchymal injury. Here, we evaluate diagnostic accuracy elevated levels plasma GFAP-BDP TBI. Participants were identified as part prospective Transforming Research And Clinical Knowledge Traumatic Brain Injury (TRACK-TBI) Study. Acute samples (<24 h post-injury) collected...
Although the majority of patients with mild traumatic brain injury (mTBI) recover completely, some still suffer from disabling ailments at 3 or 6 months. We validated existing prognostic models for mTBI and explored predictors poor outcome after mTBI. selected TRACK-TBI Pilot, an unselected observational cohort TBI three centers in United States. two Glasgow Outcome Scale Extended (GOS-E) months injury. One model was based on CRASH study data another Nijmegen, The Netherlands. Possible 3-...
<h3>Importance</h3> Mild traumatic brain injury (mTBI) affects millions of Americans each year. Lack consistent clinical practice raises concern that many patients with mTBI may not receive adequate follow-up care. <h3>Objective</h3> To characterize the provision care to during first 3 months after injury. <h3>Design, Setting, and Participants</h3> This cohort study used data on enrolled in Transforming Research Clinical Knowledge Traumatic Brain Injury (TRACK-TBI) between February 26, 2014,...
Brain-derived neurotrophic factor (BDNF) is important for neuronal survival and regeneration. We investigated the diagnostic prognostic values of serum BDNF in traumatic brain injury (TBI). examined two independent cohorts TBI cases presenting to emergency departments (EDs) Johns Hopkins Hospital (JHH; n = 76) San Francisco General (SFGH, 80), a control group JHH ED patients without (n 150). Findings were subsequently validated prospective, multi-center Transforming Research Clinical...
Brain lesions are subtle or absent in most patients with mild traumatic brain injury (mTBI) and the standard clinical criteria not reliable for predicting long-term outcome. This study investigates resting-state functional MRI (rsfMRI) to assess semiacute alterations connectivity its relationship outcome measures assessed 6 months after injury. Seventy-five mTBI were recruited as part of prospective multicenter Transforming Research Clinical Knowledge TBI (TRACK-TBI) pilot compared matched...
The idea that multiple traumatic brain injury (TBI) can have a cumulative detrimental effect on functioning is widely accepted. Most research supporting this comes from athlete samples, and it not known whether remote history of previous TBI affects after subsequent in community-based samples. This study investigates with loss consciousness (LOC) associated worse health sample individuals who require emergency department care for current TBI. Twenty-three percent the 586 Transforming...
Glial fibrillary acidic protein and its breakdown products (GFAP-BDP) are brain-specific proteins released into serum as part of the pathophysiological response after traumatic brain injury (TBI). We performed a multi-center trial to validate characterize use GFAP-BDP levels in diagnosis intracranial broad population patients with positive clinical screen for head injury. This multi-center, prospective, cohort study included 16-93 years age presenting three level 1 trauma centers suspected...
<h3>BACKGROUND AND PURPOSE:</h3> Precision medicine is an approach to disease diagnosis, treatment, and prevention that relies on quantitative biomarkers minimize the variability of individual patient measurements. The aim this study was assess intersite after harmonization a high-angular-resolution 3T diffusion tensor imaging protocol across 13 scanners at 11 academic medical centers participating in Transforming Research Clinical Knowledge Traumatic Brain Injury multisite study....
Glial fibrillary acidic protein (GFAP) is cleared by the Food and Drug Administration (FDA) to determine need for head computed tomography (CT) within 12 h after mild traumatic brain injury (TBI) (Glasgow Coma Score [GCS] 13-15); S100 calcium-binding B (S100B) serves this function in Europe. This phase 1 biomarker cohort analysis of multi-center, observational Transforming Research Clinical Knowledge Traumatic Brain Injury (TRACK-TBI) study compares GFAP's diagnostic performance, measured on...