A5087748936- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Functional Brain Connectivity Studies
- Trauma and Emergency Care Studies
- S100 Proteins and Annexins
- Neural and Behavioral Psychology Studies
- Advanced Neuroimaging Techniques and Applications
- Memory and Neural Mechanisms
- Mental Health Research Topics
- Cognitive Abilities and Testing
- Cognitive Science and Mapping
- Advanced MRI Techniques and Applications
- Immune Response and Inflammation
- Neuroendocrine regulation and behavior
- Medical Imaging and Analysis
- Human-Automation Interaction and Safety
- Health Systems, Economic Evaluations, Quality of Life
- Health disparities and outcomes
- Health, Environment, Cognitive Aging
- Frailty in Older Adults
- Privacy-Preserving Technologies in Data
- Biomedical Ethics and Regulation
- Stress Responses and Cortisol
- Medical Imaging Techniques and Applications
Washington University in St. Louis
2016-2023
Wake Forest University
2022
University of California, San Francisco
2010-2017
Neurological Surgery
2011-2017
San Francisco General Hospital
2011-2017
University of California System
2011-2017
Erasmus MC
2015
Boston University
2009
Mild Traumatic Brain Injury (mTBI), or concussion, is a major public health concern. There controversy in the literature regarding true incidence of postconcussion syndrome (PCS), with constellation physical, cognitive, emotional, and sleep symptoms after mTBI. In current study, we report on evolution PCS patient outcomes mTBI at 3, 6, 12 months large, prospective cohort patients. Participants were identified as part prospective, multi-center Transforming Research Clinical Knowledge Study....
Biomarkers are important for accurate diagnosis of complex disorders such as traumatic brain injury (TBI). For a and multifaceted condition TBI, it is likely that single biomarker will not reflect the full spectrum response tissue to injury. Ubiquitin C-terminal hydrolase L1 (UCH-L1) glial fibrillary acidic protein (GFAP) among most widely studied biomarkers TBI. Because UCH-L1 GFAP measure distinct molecular events, we hypothesized analysis both would be superior each alone prognosis Serum...
Traumatic brain injury (TBI) is among the leading causes of death and disability worldwide, with enormous negative social economic impacts. The heterogeneity TBI combined lack precise outcome measures have been central to discouraging results from clinical trials. Current approaches characterization disease severity not changed in more than three decades. This prospective multicenter observational pilot study aimed validate feasibility implementing Common Data Elements (TBI-CDEs). A total...
<h3>Importance</h3> Annually in the United States, at least 3.5 million people seek medical attention for traumatic brain injury (TBI). The development of therapies TBI is limited by absence diagnostic and prognostic biomarkers. Microtubule-associated protein tau an axonal phosphoprotein. To date, presence hypophosphorylated (P-tau) plasma from patients with acute chronic has not been investigated. <h3>Objective</h3> examine associations between P-tau total-tau (T-tau) levels presence,...
We evaluated 3T diffusion tensor imaging (DTI) for white matter injury in 76 adult mild traumatic brain (mTBI) patients at the semiacute stage (11.2±3.3 days), employing both whole-brain voxel-wise and region-of-interest (ROI) approaches. The subgroup of 32 with any intracranial lesion on either day-of-injury computed tomography (CT) or magnetic resonance (MRI) demonstrated reduced fractional anisotropy (FA) numerous tracts, compared to 50 control subjects. In contrast, 44 CT/MRI-negative...
<h3>Importance</h3> The association between poverty and unfavorable cognitive outcomes is robust, but most research has focused on individual household socioeconomic status (SES). There increasing evidence that neighborhood context explains unique variance not accounted for by SES. <h3>Objective</h3> To evaluate whether (NP) associated with function prefrontal hippocampal brain structure in ways are dissociable from <h3>Design, Setting, Participants</h3> This cross-sectional study used a...
Reliable diagnosis of traumatic brain injury (TBI) is a major public health need. Glial fibrillary acidic protein (GFAP) expressed in the central nervous system, and breakdown products (GFAP-BDP) are released following parenchymal injury. Here, we evaluate diagnostic accuracy elevated levels plasma GFAP-BDP TBI. Participants were identified as part prospective Transforming Research And Clinical Knowledge Traumatic Brain Injury (TRACK-TBI) Study. Acute samples (<24 h post-injury) collected...
Although the majority of patients with mild traumatic brain injury (mTBI) recover completely, some still suffer from disabling ailments at 3 or 6 months. We validated existing prognostic models for mTBI and explored predictors poor outcome after mTBI. selected TRACK-TBI Pilot, an unselected observational cohort TBI three centers in United States. two Glasgow Outcome Scale Extended (GOS-E) months injury. One model was based on CRASH study data another Nijmegen, The Netherlands. Possible 3-...
The idea that multiple traumatic brain injury (TBI) can have a cumulative detrimental effect on functioning is widely accepted. Most research supporting this comes from athlete samples, and it not known whether remote history of previous TBI affects after subsequent in community-based samples. This study investigates with loss consciousness (LOC) associated worse health sample individuals who require emergency department care for current TBI. Twenty-three percent the 586 Transforming...
Glial fibrillary acidic protein and its breakdown products (GFAP-BDP) are brain-specific proteins released into serum as part of the pathophysiological response after traumatic brain injury (TBI). We performed a multi-center trial to validate characterize use GFAP-BDP levels in diagnosis intracranial broad population patients with positive clinical screen for head injury. This multi-center, prospective, cohort study included 16-93 years age presenting three level 1 trauma centers suspected...
Investigating individual differences in cognition requires addressing questions not often thought about standard experimental designs, especially regarding the psychometric properties of task. Using AX-CPT cognitive control task as a case study example, we address four concerns that one may encounter when researching topic cognition. First, demonstrate importance variability scores, which turn directly impacts reliability, particularly comparing correlations different populations. Second,...
Traumatic brain injury (TBI) is a complex disorder that traditionally stratified based on clinical signs and symptoms. Recent imaging molecular biomarker innovations provide unprecedented opportunities for improved TBI precision medicine, incorporating patho-anatomical mechanisms. Complete integration of these diverse data diagnosis patient stratification remains an unmet challenge.The Transforming Research Clinical Knowledge in Brain Injury (TRACK-TBI) Pilot multicenter study enrolled 586...
We described recently a subacute serum autoantibody response toward glial fibrillary acidic protein (GFAP) and its breakdown products 5–10 days after severe traumatic brain injury (TBI). Here, we expanded our anti-GFAP (AutoAb[GFAP]) investigation to the multicenter observational study Transforming Research Clinical Knowledge in TBI Pilot (TRACK-TBI Pilot) cover full spectrum of (Glasgow Coma Scale 3–15) by using acute (<24 h) plasma samples from 196 patients with admitted three Level I...
The admission noncontrast head computed tomography (CT) scan has been demonstrated to be one of several key early clinical and imaging features in the challenging problem prediction long-term outcome after acute traumatic brain injury (TBI). In this study, we employ two novel approaches classification TBI. First, technique quantitative CT (qCT) image analysis provide more objective, reproducible measures abnormal We show that incorporation quantitative, rather than qualitative, results a...
Post-traumatic stress disorder (PTSD) is a condition associated with traumatic brain injury (TBI). While the importance of PTSD and TBI among military personnel widely recognized, there less awareness civilian TBI. We examined incidence factors 6 months post-injury in emergency department population using measures from National Institute Neurological Disorders Stroke Common Data Elements Outcome Battery. Participants mild (mTBI) Transforming Research Clinical Knowledge Traumatic Brain Injury...
Abstract It has recently been demonstrated that specific patterns of correlation exist in diffusion tensor imaging (DTI) parameters across white matter tracts the normal human brain. These microstructural correlations are thought to reflect phylogenetic and functional similarities between different axonal fiber pathways. However, this earlier work was limited three major respects: (1) analysis restricted only a dozen selected tracts; (2) DTI measurements were averaged whole tracts, whereas...
Polytrauma and traumatic brain injury (TBI) frequently co-occur outcomes are routinely measured by the Glasgow Outcome Scale-Extended (GOSE). may confound GOSE measurement of TBI-specific outcomes. Adult patients with TBI from prospective Transforming Research Clinical Knowledge in Traumatic Brain Injury Pilot (TRACK-TBI Pilot) study had presented to a Level 1 trauma center after injury, received head computed tomography (CT) within 24 h, completed at 3 months 6 post-injury. was defined as...
The Glasgow Outcome Scale-Extended (GOSE) was designed to assess global outcome after traumatic brain injury (TBI). Since its introduction, several empirically founded criticisms of the GOSE have been raised, including poor reliability; an insensitivity small, but potentially meaningful, changes; a tendency produce ceiling effects; inconsistent associations with neurocognitive, psychological, and quality-of-life measures; inability multi-dimensional nature TBI outcome. current project took...
Traumatic brain injury (TBI) is a widespread global disease, often with widely varying outcomes. Standardization of care and adherence to established guidelines are central the effort improve At our level I urban trauma center, we developed implemented Joint Commission–certified TBI Program Care in 2011 compared post-implementation patient data set historical controls, using International Mission for Prognosis Analysis Clinical Trials (IMPACT) prognostic model. Historical controls were drawn...