A5077203436- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Memory and Neural Mechanisms
- Dementia and Cognitive Impairment Research
- Sleep and related disorders
- Health, Environment, Cognitive Aging
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Child and Animal Learning Development
- Sleep and Wakefulness Research
- Neural and Behavioral Psychology Studies
- Neurological Disease Mechanisms and Treatments
- Cognitive Abilities and Testing
- Memory Processes and Influences
- Biochemical and Structural Characterization
- Click Chemistry and Applications
- Cerebrovascular and Carotid Artery Diseases
- Systemic Lupus Erythematosus Research
- Mental Health and Psychiatry
- Long-Term Effects of COVID-19
- Cell Image Analysis Techniques
- Biotin and Related Studies
- BRCA gene mutations in cancer
- Pulmonary Hypertension Research and Treatments
University of Freiburg
2023-2024
National Institute of Mental Health
2016-2022
European Thermodynamics (United Kingdom)
2021
Office of the Director
2016-2017
National Institutes of Health
2013-2017
Institute on Aging
2014-2016
National Institute on Aging
2012-2016
Walter Reed National Military Medical Center
2014-2015
The University of Texas at Austin
2009-2014
Massachusetts General Hospital
2009-2011
Traumatic brain injury (TBI) is among the leading causes of death and disability worldwide, with enormous negative social economic impacts. The heterogeneity TBI combined lack precise outcome measures have been central to discouraging results from clinical trials. Current approaches characterization disease severity not changed in more than three decades. This prospective multicenter observational pilot study aimed validate feasibility implementing Common Data Elements (TBI-CDEs). A total...
We evaluated 3T diffusion tensor imaging (DTI) for white matter injury in 76 adult mild traumatic brain (mTBI) patients at the semiacute stage (11.2±3.3 days), employing both whole-brain voxel-wise and region-of-interest (ROI) approaches. The subgroup of 32 with any intracranial lesion on either day-of-injury computed tomography (CT) or magnetic resonance (MRI) demonstrated reduced fractional anisotropy (FA) numerous tracts, compared to 50 control subjects. In contrast, 44 CT/MRI-negative...
In two experiments, younger and older adults performed decision-making tasks in which reward values available were either independent of or dependent on the previous sequence choices made. The choice-independent task involved learning exploiting options that gave highest rewards each trial. this task, stability expected for option was not influenced by participants choice-dependent how choice future making best decisions based knowledge. Younger better when choice, whereas choice. These...
Variation in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) has been associated with heightened neural activity limbic and prefrontal regions response to emotional stimuli. The current study examined whether 5-HTTLPR polymorphism is also alterations microstructure of frontal-limbic white matter (WM) tracts. Thirty-seven (mean age, 20.51 years; range, 13–28) female participants were genotyped for polymorphism. Diffusion MRI was collected a probabilistically defined tract...
The idea that multiple traumatic brain injury (TBI) can have a cumulative detrimental effect on functioning is widely accepted. Most research supporting this comes from athlete samples, and it not known whether remote history of previous TBI affects after subsequent in community-based samples. This study investigates with loss consciousness (LOC) associated worse health sample individuals who require emergency department care for current TBI. Twenty-three percent the 586 Transforming...
To determine the association between self-reported sleep duration and cortical thinning among older adults.We studied 122 cognitively normal participants in Baltimore Longitudinal Study of Aging with a mean age = 66.6 y (range, 51-84) at baseline assessment 69.5 56-86) initial magnetic resonance imaging (MRI) scan. Participants reported average completed 7.6 1.5-T MRI scans 3-11), follow-up from scan 8.0 2.0-11.8).In analyses adjusted for age, sex, education, race, interval scan, reporting >...
Cortical surface area measures appear to be functionally relevant and distinct in etiology, development, behavioral correlates compared with other size characteristics, such as cortical thickness. Little is known about genetic environmental influences on individual differences regional humans. Using a large sample of adult twins, we determined relative contributions genes environment variations measured by magnetic resonance imaging before after adjustment for shared total area. We found...
Objectives:In other disciplines, white matter (WM) differences have been linked to cognitive impairments. This study sets out clarify whether similar microstructural in WM tracts predict a person's vulnerability the effects of total sleep deprivation (TSD).
Interleukin-6 (IL-6) is a pro-inflammatory cytokine produced by immune cells and other cell types such as microglia throughout the brain. Higher levels of IL-6 in older adults have been cross-sectionally longitudinally associated with physical cognitive impairment, well increased dementia risk. The association between structural functional brain changes less clear. In present study, we investigated relationship concentrations cortical thinning aging. Magnetic Resonance Imaging (MRI) scans...
Little is known about genetic influences on the volume of subcortical brain structures in adult humans, particularly whether there regional specificity effects. Understanding patterns covariation among volumes may provide insight into development individual differences that have consequences for cognitive and emotional behavior neuropsychiatric disease liability. We measured 19 (including ventricular regions) 404 twins (110 monozygotic 92 dizygotic pairs) from Vietnam Era Twin Study Aging...
Background: Cross-sectional studies of the association between hypertension (HTN) and brain atrophy have shown reductions in prefrontal, temporal, hippocampal volumes, identified thinner cortices across cortical mantle. Method: In current study, we followed 96 participants enrolled Baltimore Longitudinal Study Aging over a mean interval 8 years (mean age at baseline = 68.7) compared those who are hypertensive (n 49) throughout study with normotensive 47). Results: Hypertensive individuals...
Dissociable prototype learning systems have been demonstrated behaviorally and with neuroimaging in younger adults as well patient populations. In A/not-A (AN) learning, participants are shown members of category A during training, test asked to decide whether novel items or not A. Research suggests that AN is mediated by a perceptual system. A/B (AB) B B. contrast AN, research AB declarative memory The current study examined the effects normal aging on learning. We observed an age-related...
Longitudinal analysis of magnetic resonance images the human brain provides knowledge changes during both normal aging as well progression many diseases. Previous longitudinal segmentation methods have either ignored temporal information or incorporated consistency constraints within algorithm. In this work, we assume that some anatomical can be explained by transitions in image intensities. Once are aligned same space, intensities each scan at voxel constitute a (or 4D) intensity trend...
Abstract The site‐specific and covalent conjugation of proteins on solid supports in hydrogels is the basis for synthesis biohybrid materials offering broad applications. Current methods conjugating to desired targets are often challenging due unspecific binding, unstable (noncovalent) coupling, or expensive difficult‐to‐synthesize ligand molecules. Here, presented PenTag, an approach bioorthogonal, highly specific, a protein its various applications sciences. Penicillin‐binding 3 (PBP3)...