A5058359516- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Microfluidic and Capillary Electrophoresis Applications
- Molecular Communication and Nanonetworks
- Antibiotics Pharmacokinetics and Efficacy
- Biochemical and Structural Characterization
- Ophthalmology and Visual Health Research
- SARS-CoV-2 detection and testing
- Innovative Microfluidic and Catalytic Techniques Innovation
- CRISPR and Genetic Engineering
- Click Chemistry and Applications
- Neuroscience and Neural Engineering
- Diatoms and Algae Research
- Biotin and Related Studies
- Ottoman and Turkish Studies
- Date Palm Research Studies
- RNA Interference and Gene Delivery
- Molecular Junctions and Nanostructures
- Nuts composition and effects
- Advanced MEMS and NEMS Technologies
- Polymer Surface Interaction Studies
- Anodic Oxide Films and Nanostructures
- Microbial Fuel Cells and Bioremediation
- 3D Printing in Biomedical Research
- Reproductive tract infections research
University of Freiburg
2020-2025
Leibniz-Institute for New Materials
2023-2025
Saarland University
2023-2024
Abstract Personalized antibiotherapy ensures that the antibiotic concentration remains in optimal therapeutic window to maximize efficacy, minimize side effects, and avoid emergence of drug resistance due insufficient dosing. However, such individualized schemes need frequent sampling tailor blood concentrations. To optimally integrate monitoring (TDM) into clinical workflow, levels can either be measured using point‐of‐care testing (POCT), or rely on noninvasive sampling. Here, a versatile...
In late 2019 SARS-CoV-2 rapidly spread to become a global pandemic, therefore, measures attenuate chains of infection, such as high-throughput screenings and isolation carriers were taken. Prerequisite for reasonable democratic implementation measures, however, is the availability sufficient testing opportunities (beyond reverse transcription PCR, current gold standard). We, propose an electrochemical, microfluidic multiplexed polymer-based biosensor in combination with CRISPR/Cas-powered...
Abstract Clinical assessment based on a single biomarker is in many circumstances not sufficient for adequate diagnosis of disease or monitoring its therapy. Multiplexing, the measurement multiple analytes from one sample and/or same target different samples simultaneously, could enhance accuracy diseases and their therapy success. Thus, there great urgent demand multiplexed biosensors allowing low-cost, easy-to-use, rapid on-site testing. In this work, we present simple, flexible, highly...
Synthetic biology applies concepts from electrical engineering and information processing to endow cells with computational functionality. Transferring the underlying molecular components into materials wiring them according topologies inspired by electronic circuit boards has yielded systems that perform selected operations. However, limited functionality of available building blocks is restricting implementation advanced information-processing circuits materials. Here, a set protease-based...
Abstract In late 2019 SARS-CoV-2 rapidly spread to become a global pandemic, therefore, measures attenuate chains of infection, such as high-throughput screenings and isolation carriers were taken. Prerequisite for reasonable democratic implementation measures, however, is the availability sufficient testing opportunities (beyond reverse transcription PCR, current gold standard). We, propose an electrochemical, microfluidic multiplexed biosensor in combination with CRISPR/Cas-powered assays...
Information-Processing Materials Biohybrid materials that communicate with each other via diffusible inhibitory or activating signals are assembled in a circuit topology inspired by an electronical binary 2-input/4-output decoder. The biomolecular decoder is programmed to convert specific molecular inputs into the release of distinct protease outputs. Such information-processing biohybrid material circuits can be used for computing and sensor signal processing. More details found article...
Abstract The functional integration of biological switches with synthetic building blocks enables the design modular, stimulus-responsive biohybrid materials. By connecting individual modules via diffusible signals, information-processing circuits can be designed. Such systems are, however, mostly limited to respond either small molecules, proteins, or optical input thus limiting sensing and application scope material circuits. Here, we a highly modular based on CRISPR-Cas13a translate...
Abstract The functional integration of biological switches with synthetic building blocks enables the design modular, stimulus‐responsive biohybrid materials. By connecting individual modules via diffusible signals, information‐processing circuits can be designed. Such systems are, however, mostly limited to respond either small molecules, proteins, or optical input thus limiting sensing and application scope material circuits. Here, a highly modular is based on CRISPR/Cas13a translate...
Abstract The site-specific and covalent conjugation of proteins on solid supports in hydrogels is the basis for synthesis biohybrid materials offering broad applications. Current methods conjugating to desired targets are often challenging due unspecific binding, unstable (non-covalent) coupling, or expensive difficult-to-synthesize ligand molecules. Here, we present PenTag, an approach biorthogonal, highly-specific a protein its various applications sciences. We engineered penicillin-...
Abstract The site‐specific and covalent conjugation of proteins on solid supports in hydrogels is the basis for synthesis biohybrid materials offering broad applications. Current methods conjugating to desired targets are often challenging due unspecific binding, unstable (noncovalent) coupling, or expensive difficult‐to‐synthesize ligand molecules. Here, presented PenTag, an approach bioorthogonal, highly specific, a protein its various applications sciences. Penicillin‐binding 3 (PBP3)...
Personalized Antibiotherapy In article number 2104555, Can Dincer and co-workers introduce an electrochemical multiplexed biosensor combined with a synthetic-biology-empowered assay, which enables simple, yet accurate method to provide insights regarding the antibiotic levels even in exhaled breath condensate. The validated findings demonstrate potential of system shift paradigm “one size-fits-all” strategy for combating resistance.
Abstract Antimicrobial resistance is increasing with an alarming rate for which the prime suspect “one size-fits-all” dosage strategies of antibiotics. Personalized antibiotherapy framework appears as a viable option to counteract inadequate dosage, it offers application optimal regimen each individual. Such individualized scheme, however, needs frequent sampling tailor blood antibiotic concentration respond unique pharmacokinetic/pharmacodynamic (PK/PD) patient. Herein, there are two...
Abstract Synthetic biology applies concepts from electrical engineering and information processing to endow cells with computational functionality. Transferring the underlying molecular components into materials wiring them according topologies inspired by electronic circuit boards has yielded systems that perform selected operations. However, limited functionality of available building blocks is restricting implementation advanced information-processing circuits materials. Here, we engineer...