A5036270328- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Antibiotics Pharmacokinetics and Efficacy
- Microfluidic and Capillary Electrophoresis Applications
- SARS-CoV-2 detection and testing
- Advanced Sensor and Energy Harvesting Materials
- Non-Invasive Vital Sign Monitoring
- Advanced Biosensing Techniques and Applications
- Sepsis Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Cardiovascular and exercise physiology
- Monoclonal and Polyclonal Antibodies Research
- Analytical Methods in Pharmaceuticals
- Innovative Microfluidic and Catalytic Techniques Innovation
- Green IT and Sustainability
- Cancer Cells and Metastasis
- Pneumonia and Respiratory Infections
- ECG Monitoring and Analysis
- Microfluidic and Bio-sensing Technologies
- Advanced Chemical Sensor Technologies
- 3D Printing in Biomedical Research
- Ergonomics and Musculoskeletal Disorders
- Analytical Chemistry and Sensors
- COVID-19 diagnosis using AI
University of Freiburg
2020-2024
Middle East Technical University
2018
Wearable electronic devices, which allow physiological signals to be continuously monitored, can used in the early detection of asymptomatic and pre-symptomatic cases COVID-19.
Abstract “Sample‐in‐answer‐out” type integrated diagnostic devices have been widely recognized as the ultimate solution to simplify testing across healthcare systems. Such systems are equipped with advanced fluidic, mechanical, chemical, biological, and electronic components handle patient samples without any manual steps therefore potential accelerate intervention improve outcomes. In this regard, combination of non‐invasive sampling has gained a substantial interest further comfort safety...
Abstract Personalized antibiotherapy ensures that the antibiotic concentration remains in optimal therapeutic window to maximize efficacy, minimize side effects, and avoid emergence of drug resistance due insufficient dosing. However, such individualized schemes need frequent sampling tailor blood concentrations. To optimally integrate monitoring (TDM) into clinical workflow, levels can either be measured using point‐of‐care testing (POCT), or rely on noninvasive sampling. Here, a versatile...
In late 2019 SARS-CoV-2 rapidly spread to become a global pandemic, therefore, measures attenuate chains of infection, such as high-throughput screenings and isolation carriers were taken. Prerequisite for reasonable democratic implementation measures, however, is the availability sufficient testing opportunities (beyond reverse transcription PCR, current gold standard). We, propose an electrochemical, microfluidic multiplexed polymer-based biosensor in combination with CRISPR/Cas-powered...
Abstract Clinical assessment based on a single biomarker is in many circumstances not sufficient for adequate diagnosis of disease or monitoring its therapy. Multiplexing, the measurement multiple analytes from one sample and/or same target different samples simultaneously, could enhance accuracy diseases and their therapy success. Thus, there great urgent demand multiplexed biosensors allowing low-cost, easy-to-use, rapid on-site testing. In this work, we present simple, flexible, highly...
Clinical studies investigating the benefits of beta-lactam therapeutic drug monitoring (TDM) among critically ill patients are hindered by small patient groups, variability between studies, heterogeneity, and inadequate use TDM. Accordingly, definitive conclusions regarding efficacy TDM remain elusive. To address these challenges, we propose an innovative approach that leverages data-driven methods to unveil concealed connections therapy effectiveness data, collected through a randomized...
Rituximab (RTX) is a specific monoclonal antibody for CD20 protein, which are mostly found in lymphocytes B. RTX notably indicated lymphomas, autoimmune disorders, leukemia and transplant rejections. A higher efficiency achieved by adjusted doses, tailored individual body weight pharmacokinetic parameters. Therefore, the individualized dosing usual practice to achieve therapeutic success of this expensive drug. Therapeutic monitoring commonly performed chromatographic methods or...
Abstract In late 2019 SARS-CoV-2 rapidly spread to become a global pandemic, therefore, measures attenuate chains of infection, such as high-throughput screenings and isolation carriers were taken. Prerequisite for reasonable democratic implementation measures, however, is the availability sufficient testing opportunities (beyond reverse transcription PCR, current gold standard). We, propose an electrochemical, microfluidic multiplexed biosensor in combination with CRISPR/Cas-powered assays...
Methods for isolation and quantification of circulating tumor cells (CTCs) are attracting more attention every day, as the data their unprecedented clinical utility continue to grow. However, challenge is that CTCs extremely rare (as low 1 in a billion blood cells) highly sensitive specific technology required isolate from cells. utilizing microfluidic systems immunoaffinity-based CTC capture preferred, especially when purity prime requirement. antibody immobilization strategy significantly...
Abstract Clinical studies investigating the benefits of beta-lactam therapeutic drug monitoring (TDM) among critically ill patients have been hindered by small patient group, variability between studies, heterogeneity and inadequate use TDM. Accordingly, definitive conclusions regarding efficacy TDM remained elusive. To address these challenges, we propose an innovative approach that leverages data-driven methods to unveil concealed connections therapy effectiveness data. Our findings reveal...
In article number 2010388, Can Dincer and co-workers present integrated “sample-to-answer” diagnostic platforms including wearable, handheld, tabletop devices for non-invasive monitoring. Factors influencing the translation of these from fundamental research phase through commercialization into our daily life are discussed via technology readiness level concept. Image designed by Ceren Ates created Ella Maru Studio.
Personalized Antibiotherapy In article number 2104555, Can Dincer and co-workers introduce an electrochemical multiplexed biosensor combined with a synthetic-biology-empowered assay, which enables simple, yet accurate method to provide insights regarding the antibiotic levels even in exhaled breath condensate. The validated findings demonstrate potential of system shift paradigm “one size-fits-all” strategy for combating resistance.
Abstract Antimicrobial resistance is increasing with an alarming rate for which the prime suspect “one size-fits-all” dosage strategies of antibiotics. Personalized antibiotherapy framework appears as a viable option to counteract inadequate dosage, it offers application optimal regimen each individual. Such individualized scheme, however, needs frequent sampling tailor blood antibiotic concentration respond unique pharmacokinetic/pharmacodynamic (PK/PD) patient. Herein, there are two...