A5002161518- BRCA gene mutations in cancer
- Spinal Dysraphism and Malformations
- Traumatic Brain Injury and Neurovascular Disturbances
- Chromosomal and Genetic Variations
- Genetics, Bioinformatics, and Biomedical Research
- Traumatic Brain Injury Research
- Cerebrospinal fluid and hydrocephalus
- Surgical Simulation and Training
- Ethics in Clinical Research
- RNA and protein synthesis mechanisms
- Global Cancer Incidence and Screening
- Diversity and Career in Medicine
- Pediatric Urology and Nephrology Studies
- Ethics in medical practice
- Spine and Intervertebral Disc Pathology
- Plant Virus Research Studies
- Hernia repair and management
- Spinal Hematomas and Complications
- Head and Neck Surgical Oncology
- Nutrition, Genetics, and Disease
- Trauma and Emergency Care Studies
- Jewish and Middle Eastern Studies
- Congenital heart defects research
- Medical Imaging and Analysis
- Cancer Risks and Factors
Neurological Surgery
2019-2024
University of Washington
1994-2024
Seattle University
1996-2023
Seattle Children's Hospital
2022
Harborview Medical Center
2021
Virginia Mason Medical Center
2018-2020
Oxford University Press (United Kingdom)
2020
Illumina (United States)
2001
University of Washington Medical Center
1993-1998
University of California, Los Angeles
1997
We report on results of an interview study assessing women's attitudes toward and hypothetical interest in genetic susceptibility testing for breast cancer. Data are from 246 interviews with women varying ethnicity (African American, European Native Ashkenazi Jewish), family history cancer (negative, positive, borderline), educational level. Semistructured included questions general health beliefs; attitudes, experiences, concerns about cancer; testing. Influence specific test...
Abstract Background Most glioblastomas recur near prior radiation treatment sites. Future clinical success will require achieving and optimizing an “abscopal effect,” whereby unirradiated neoplastic cells outside sites are recognized attacked by the immune system. Radiation combined with anti–programmed cell death ligand 1 (PD-L1) demonstrated modest efficacy in phase II human glioblastoma trials, but mechanism relevance of abscopal effect during this response remain unknown. Methods We...
To understand evolutionary events in the formation of higher-order repeat units alpha satellite DNA, we have examined gorilla sequences homologous to human X chromosome satellite. In humans, on is organized as a tandemly repeated, 2.0 × 103 base-pairs (bp) unit, operationally defined by restriction enzyme BamHI. Each unit composed 12 tandem approximately 171 base-pair monomer that been classified into five distinct sequence homology groups. BamHI-digested genomic DNA hybridized with cloned 2...
<b>Objective:</b> Genetic testing for cancer risk will shortly enter medical practice. Our intent was to increase the understanding of public’s attitudes towards and potential demand genetic testing. <b>Methods:</b> We conducted a random-digit-dial survey 1,450 adults in Washington State assess toward investigate correlates intention be tested breast (women) prostate (men). No specific genes were mentioned, as understand general interest screening risks. The addressed...
OBJECTIVE In this research, the authors sought to characterize incidence and extent of cerebrovascular lesions after penetrating brain injury in a civilian population compare diagnostic value head computed tomography angiography (CTA) digital subtraction (DSA) their diagnosis. METHODS This was prospective multicenter cohort study patients with due any mechanism presenting at two academic medical centers over 3-year period (May 2020 May 2023). All underwent both CTA DSA. The sensitivity...
Subependymal giant cell astrocytoma (SEGA) is the most common CNS tumor in patients with tuberous sclerosis complex (TSC). Although these are benign, their proximity to foramen of Monroe frequently causes obstructive hydrocephalus, a potentially fatal complication. Open surgical resection has been mainstay treatment; however, this can cause significant morbidity. The development mTOR inhibitors changed treatment landscape, but there limitations use. Laser interstitial thermal therapy (LITT)...
Interlaminar endoscopic spine surgery has been introduced and utilized for lumbar lateral recess decompression. We modified this technique it bilateral stenoses without significant central stenosis. Here we present the surgical details clinical outcome of ligamentum flavum sparing unilateral laminotomy decompression (ULBRD).Prospectively collected registry full-endoscopic surgeries was reviewed retrospectively. One hundred eighty-two consecutive cases from a single center between September...
Tethered cord syndrome refers to a constellation of symptoms characterized by neurological, musculoskeletal, and urinary symptoms, caused traction on the spinal cord, which can be secondary various etiologies. Surgical management simple tethered etiologies (e.g., fatty filum) typically consists single-level lumbar laminectomy, intradural exploration, coagulation sectioning filum. More complex such as lipomyelomeningoceles or scar formation after myelomeningocele repair involve dissection...
OBJECTIVE Spina bifida represents one of the most common birth defects, occurring in approximately 1–2 children per 1000 live births worldwide. The functional level patients with spina is highly variable and believed to be correlated anatomical lesion. clinical picture well established, but correlation intraoperative neuromonitoring (IONM) data has not been investigated. Furthermore, potential for preserving function beyond apparent also objective this research was determine presence...
The identification of genetic mutations linked to breast cancer has made it possible test for the predisposition this disease. However, though may provide certain benefits, there are also potential risks involved with testing process, including social and economic considerations. In light these risks, we sought determine what information individuals receiving in informed decision making process. To learn minimal amount actual testees receive, obtained 10 consent forms from seven different...
While a select population of pediatric patients with Chiari malformation type I (CM-I) remain asymptomatic, some present tussive headaches, neurological deficits, progressive scoliosis, and other debilitating symptoms that necessitate surgical intervention. Surgery entails variety strategies to restore normal CSF flow, including increasing the posterior fossa volume via bone decompression only, or duraplasty, without obex exploration. The indications for duraplasty exploration following...
Purpose To identify demographic and clinical characteristics of patients with symptomatic pelvic floor mesh complications who underwent removal at our academic medical center. The secondary goal was to determine patient-reported outcomes after removal. Materials methods We conducted a retrospective review consecutive from 2011-2016 undergoing graft for treatment mesh-related complications. Patient demographics, comorbidities, symptoms, factors were evaluated. Outcomes explant determined by...
Abstract The identification of the common mutations cystic fibrosis (CF) transmembrane conductance regulator gene has made it feasible to consider population‐based CF carrier screening. However, demand for such programs will depend largely on attitudes and perceptions general public toward genetic testing. As part a high school science project, we initiated studies determine students screening other disorders. From class 120 biology students, 101 consented participate in study. Most were...