The intervertebral disc (IVD) is an avascular structure, and therefore stable under hypoxic conditions. Previous studies have demonstrated that hypoxia might be related to symptomatic degenerative diseases (DDDs); however, the pathomechanism still poorly understood.To identify effect of on production inflammatory mediators, angiogenic factors, extracellular matrix-regulating enzymes IVD cells during reactions.Human nucleus pulposus (NP) annulus fibrosus (AF) harvested surgery for DDDs were...

A retrospective review.We investigated the longitudinal change of cervical alignment parameters including C2-7 lordosis, sagittal vertical axis (SVA), T1 slope, and segmental angle (SA) after two-level anterior discectomy fusion (ACDF).Cervical may influence postoperative clinical outcomes. Several studies have suggested that serve as a parameter for assessing deformities similar to those used assess thoracolumbar spine deformities. However, our knowledge, no effect ACDF on alignment.We...

Bleeding is a commonly encountered problem in spine surgery. The increasing popularity of endoscopic surgery poses new challenges to surgeons, especially those who are embarking on the learning curve. Hemostasis can be difficult due narrow working channel and bleeding obscuring view, which hinders hemostasis effective continuation operation. To minimize risk improve hemostasis, multimodal approach should employed, including appropriate strategies for perioperative prevention, intraoperative...

We aimed to investigate operating conditions, postoperative pain, and overall satisfaction of surgeons using deep neuromuscular blockade (NMB) vs. no NMB in patients undergoing lumbar spinal surgery under general anesthesia. Eighty-three fusion were randomly assigned receive (n = 43) or 40). In the deep-NMB group, rocuronium was administered maintain (train-of-four count 0, post-tetanic 1–2) until end surgery. no-NMB sugammadex 4 mg/kg at train-of-four (TOF) 0–1 2 TOF ≥2 reverse 10 min after...

Our purpose of this study was to assess the cerebral hemodynamic improvement with perfusion computed tomography (CT), before and after superficial temporal artery (STA) middle (MCA) bypass surgery in patients cerebrovascular steno-occlusive diseases including both moyamoya disease nonmoyamoya steno-occlusions.Twenty-four STA-MCA bypasses were performed 22 symptomatic diseases, diseases. Brain CT images obtained surgery. The relative parameters such as blood volume (CBV), flow (CBF), mean...

Objective: To demonstrate the non-inferiority of novel hemostatic agent, Hemofence ® (BMI Korea Co. Ltd., Jeju Korea, thrombin cross-linked sodium hyaluronate gel matrix) compared to established Floseal Hemostatic Matrix (Baxter, thrombin-gelatin in achieving hemostasis for spinal surgeries, with secondary objectives assess additional efficacy and safety.Methods: This clinical trial was a multicenter, randomized, subject-blinded, active-controlled, parallelgroup, phase 3...

ABSTRACT Ligamentum flavum hypertrophy (LFH) is the most important component of lumbar spinal canal stenosis. Although pathophysiology LFH has been extensively studied, no method proposed to prevent or treat it. Since transforming growth factor‐β (TGF‐β) pathway known be critical in pathology, we investigated whether could prevented by blocking modulating TGF‐β mechanism. Human LF cells were used for experiments. First, created receptor 1 (TGFBR1) knock out (KO) with CRISPR (clustered...

The aneurysm arising from fenestrated proximal anterior cerebral artery (ACA) is considered to be unique. authors report a case of 59-year-old woman who presented with subarachnoid hemorrhage (SAH) secondary ruptured originating the A1 segment right ACA. patient had another unruptured which was located at middle bifurcation. She successfully treated surgical clipping for both aneurysms. From previously existing literatures, we found 18 more cases (1983-2011) aneurysms associated segment. All...

Interlaminar endoscopic spine surgery has been introduced and utilized for lumbar lateral recess decompression. We modified this technique it bilateral stenoses without significant central stenosis. Here we present the surgical details clinical outcome of ligamentum flavum sparing unilateral laminotomy decompression (ULBRD).Prospectively collected registry full-endoscopic surgeries was reviewed retrospectively. One hundred eighty-two consecutive cases from a single center between September...

Fully endoscopic lumbar surgery has emerged as an alternative technique to classic open microscopic laminectomy or discectomy. It is gaining popularity due its advantages in terms of minimal invasiveness, while achieving equivalent clinical outcomes. Remarkable technical developments surgical techniques and instruments have expanded the indications this method. However, utilization increases, related complications inevitably arise become major issues. Frequent include failure achieve...

Ligamentum flavum hypertrophy (LFH) is a known contributor to lumbar spinal canal stenosis (LSCS). However, the clinical significance and quantitative role of LFH compared other components, such as disc bulging facet hypertrophy, have not yet been examined. We investigated correlation between radiological factors, symptoms, outcomes in patients with LSCS. In total, 163 diagnosed single-level (L4–L5) were included. The divided into 2 groups according claudication severity: >100 m for mild...

Since the first discovery of 2019 novel coronavirus (COVID-19), rapid and wide spread disease has been reported World Health Organization announced that a 'pandemic' started. Up to date there is little known regarding impact this outbreak on spinal specialists' daily clinical practice. We intended evaluate how COVID-19 affected number patients we meet operate in practice.The de-identified data visiting spine clinic at tertiary referral hospital secondary level from January, February March...

Objective The feasibility and usefulness of transradial catheterization for coronary neuro-intervention are well known. However, the anatomical change in catheterized radial artery (RA) is not understood. Herein, we present results ultrasonographic observation RA after routine cerebral angiography (TRCA). Methods Patients who underwent TRCA with pre- post-procedure Doppler ultrasonography (DUS) were enrolled. We then recorded retrospectively reviewed diameter any complicated features...