A5003327429- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Spine and Intervertebral Disc Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Fractures and Fixation Techniques
- Cerebrospinal fluid and hydrocephalus
- Vascular Malformations Diagnosis and Treatment
- Musculoskeletal pain and rehabilitation
- Cerebrovascular and Carotid Artery Diseases
- Glioma Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Pituitary Gland Disorders and Treatments
- Bone Tumor Diagnosis and Treatments
- Spinal Hematomas and Complications
- History of Medical Practice
- Spinal Cord Injury Research
- Craniofacial Disorders and Treatments
- Spinal Dysraphism and Malformations
- Anesthesia and Pain Management
- Moyamoya disease diagnosis and treatment
- Nerve Injury and Rehabilitation
- Pain Management and Opioid Use
- Acute Ischemic Stroke Management
- Surgical Simulation and Training
University of Wisconsin–Madison
2022-2024
Hamad Medical Corporation
2024
Brigham and Women's Hospital
2015-2024
Harvard University
2015-2024
Commonwealth Medical College
2023-2024
Neurological Surgery
2017-2024
Spaulding Rehabilitation Hospital
2015-2024
Mass General Brigham
2023-2024
Geisinger Health System
2024
University of Washington
2021-2022
Significance We developed a platform technology to determine therapeutic mechanisms of human mesenchymal stromal stem cells (hMSCs) in dorsal root ganglion coculture system and an intraspinal cord implantation model. The unique poly(lactic- co- glycolic) acid scaffolding augments hMSC stemness, engraftment, function without neural transdifferentiation or lineage development, resulting robust motosensory improvement, pain tissue damage mitigation, myelin preservation adult rat spinal after...
Cranioplasty is a technically simple procedure, although one with potentially high rates of complications. The ideal timing cranioplasty should minimize the risk complications, but research investigating and complications has generated diverse findings. Previous studies have included mixed populations patients undergoing following decompression for traumatic, vascular, other cerebral insults, making results challenging to interpret. objective current study was examine associated...
OBJECTIVE The opioid crisis is identified as a national emergency and epidemic in the United States. aim of this study was to identify risk factors associated with dependence patients undergoing surgery for degenerative spondylolisthesis (DS). METHODS authors queried MarketScan databases investigate affecting postsurgery use DS between 2000 2012. outcome interest dependence, which defined continued use, > 10 prescriptions, or diagnosis prescription disorder period 1 year before 3-15 months...
Cognitive dysfunction occurs in up to 70% of aneurysmal subarachnoid hemorrhage (aSAH) survivors. Low-dose intravenous heparin (LDIVH) infusion using the Maryland protocol was recently shown reduce clinical vasospasm and vasospasm-related infarction. In this study, Montreal Assessment (MoCA) used evaluate cognitive changes aSAH patients treated with LDIVH compared controls.
There are currently no satisfactory treatments or experimental models showing autonomic dysfunction for intramedullary spinal cord gliomas (ISCG).To develop a rat model of ISCG and investigate whether genetically engineered human neural stem cells (F3.hNSCs) could be developed into effective therapies ISCG.Immunodeficient/Rowett Nude rats received C6 implantation G55 glioblastoma (10K/each). F3.hNSCs to express either cytosine deaminase gene only (i.e., F3.CD) dual genes CD thymidine kinase...
Central nervous system infection with Cladophialophora bantiana (Black Mold) is rare. It carries a high mortality rate, that more than 70%, despite multimodal therapy.We present rare case of "black mold" fungal brain abscess was successfully treated good patient outcome. The unusual because there were two abscesses located bilaterally symmetrically in the mesial frontal lobes, and response to different treatment strategies well documented by over 25 magnetic resonance imaging (MRI) scans....
Cranioplasty is a neurosurgical procedure to repair skull defects. Sometimes, the patients' bone flap cannot be used for various reasons. Alternatives include custom polyether ether ketone (PEEK) implant or titanium mesh; both incur an additional cost. We present technique that uses 3D printer create patient- specific model mold mesh preoperatively.We included three patients whose could not used. collected demographics, cost, and time data implants printer. The computed tomography DICOM...
Given the complexity of clinical course, psychosocial, operative, and postoperative nature, accompanying significant rates morbidity mortality associated with
OBJECTIVE Opioid abuse is highly prevalent in patients with back pain. The aim of this study was to identify health care utilization and overall costs associated opioid dependence undergoing surgery for degenerative spondylolisthesis (DS). METHODS authors queried the MarketScan database using ICD-9 CPT-4 codes from 2000 2012. dependency defined as having a diagnosis use disorder, prescription or 10 more prescriptions. evaluated 12-month period leading 3-15 months following procedure....
The adult rodent spinal cord presents an inhibitory environment for donor cell survival, impeding efficiency xenograft-based modeling of gliomas. We postulated that mild thermal preconditioning may influence the fate implanted tumor cells. To test this hypothesis, high-grade human astrocytoma G55 and U87 cells were cultured under 37C 38.5C to mimic regular experimental or core body temperatures rodents, respectively. In vitro, 38.5C-conditioned cells, relative 37C, grew slightly faster....
Dorsal arachnoid webs (DAWs) are rare clinical entities that can mimic other conditions on magnetic resonance imaging (MRI). Here, we present a case of DAW was misdiagnosed MR as ventral cord herniation.A 35-year-old female presented with 1-year history lower extremity weakness and numbness. The MRI the thoracic spine showed displacement syringomyelia. computed tomography myelogram demonstrated herniation. Intraoperatively, patient had dorsal web in absence Within 8 postoperative weeks,...
Tarlov (perineural) cysts of the nerve root are common and usually incidental findings during magnetic resonance imaging (MRI) lumbosacral spine. There a few case reports where symptomatic thoracic perineural have been described in literature. We report high cyst that failed conservative therapy, requiring surgical intervention. Our patient presented with radicular symptoms involving left hand. Imaging workup revealed cystic lesion T1 at level foramen. Surgical resection resulted significant...
OBJECTIVE The purpose of this study was to describe effects adjuvant radiotherapy (RT) for anaplastic meningiomas (AMs) on long-term survival, and analyze patient RT characteristics associated with survival. METHODS authors queried a retrospective cohort patients AM from the National Cancer Database (NCDB) diagnosed between 2004 2015 treatment trends. For outcome analysis, at least 10 years follow-up were included, they stratified based status propensity matched controls covariates. Survival...