A5002215896- Gastrointestinal motility and disorders
- Natural Language Processing Techniques
- Diet and metabolism studies
- Testicular diseases and treatments
- Eosinophilic Esophagitis
- semigroups and automata theory
- Sexual Differentiation and Disorders
- Cerebrospinal fluid and hydrocephalus
- Logic, programming, and type systems
- Brain Metastases and Treatment
- Gastrointestinal disorders and treatments
- Breast Cancer Treatment Studies
- Glioma Diagnosis and Treatment
- Gene expression and cancer classification
- Infant Health and Development
- Traumatic Brain Injury and Neurovascular Disturbances
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- HER2/EGFR in Cancer Research
- Ethics and Legal Issues in Pediatric Healthcare
- Urologic and reproductive health conditions
- Protease and Inhibitor Mechanisms
- Pregnancy and preeclampsia studies
- COVID-19 Impact on Reproduction
- Gastroesophageal reflux and treatments
Norton Healthcare
2021-2025
University of Louisville
2016-2025
United States Army
2024
Oak Ridge Institute for Science and Education
2024
U.S. Army Research Institute of Environmental Medicine
2024
Oak Ridge Associated Universities
2024
Primary Source
2023
University of Louisville Hospital
2023
Quality Research
2021
University Ucinf
2020
Background: Patients with brain metastases and concurrent hydrocephalus warrant expedited treatment. This study evaluated survival outcomes of patients treated endoscopic third ventriculostomy (ETV) or ventriculoperitoneal shunt (VPS) placement. Materials methods: Twenty were ETV VPS over 10 years (July 18, 2013-November 20, 2023). Our findings juxtaposed against data from 77 published controls to assess whether management correlated enhanced survival. Results: The most common primary cancer...
Background Diffuse midline gliomas (DMG) are a subset of malignant that could be linked to an H3K27M mutation. Hydrocephalus may the initial presenting condition because its frequent pontine location. This study evaluated outcomes tumor resection, endoscopic third ventriculostomy (ETV), and ventriculoperitoneal shunt (VPS) placement in DMG patients compared wild-type (WT) tumors treating hydrocephalus. Materials methods We identified newly diagnosed pediatric adult with over eight-year...
Background Cerebral radiation necrosis (RN) is a chronic inflammatory process that may develop following radiotherapy for primary or metastatic brain tumor arteriovenous malformation (AVM). A single infusion dose of intra-arterial (IA) bevacizumab (BV) viable option. The aim this study was to assess the safety and efficacy IA BV in patients with steroid-refractory cerebral RN. Materials methods total 33 imaging-confirmed RN underwent at least one over 9-year duration. administered as 2.5...
Background The impact of SARS-CoV-2 on pregnancy outcomes is unclear, but evidence suggests increased perinatal loss due to placental damage and fetal oxygen deprivation. Objective This study compared findings between pre-COVID-19 COVID-19 periods assess the association abnormal pathology complications. It was hypothesized that COVID-19-positive pregnancies would have higher rates intrauterine demise growth restriction virus-induced injury. Study Design A retrospective analysis 34,102...
Abstract Mutations in oncogenes and tumor suppressor genes engender unique metabolic phenotypes crucial to the survival of cells. EGFR signaling has been linked rewiring metabolism non–small cell lung cancer (NSCLC). We have integrated use a functional genomics screen metabolomics identify vulnerabilities induced by inhibition. These studies reveal that following inhibition, EGFR-driven NSCLC cells become dependent on urea cycle and, particular, enzyme CPS1. Combining knockdown CPS1 with...
Background: Frameless image-guided radiosurgery (IGRS) is an effective and non-invasive method of treating patients who are unresponsive to medical management for trigeminal neuralgia (TN). This study evaluated the use frameless IGRS treat with medically refractory TN. Methods: We performed a retrospective review records 116 diagnosed TN underwent using linear accelerator (LINAC) over 10 years (March 2012-February 2023). All had failed Facial pain was graded Barrow Neurological Institute...
Cognitive dysfunction occurs in up to 70% of aneurysmal subarachnoid hemorrhage (aSAH) survivors. Low-dose intravenous heparin (LDIVH) infusion using the Maryland protocol was recently shown reduce clinical vasospasm and vasospasm-related infarction. In this study, Montreal Assessment (MoCA) used evaluate cognitive changes aSAH patients treated with LDIVH compared controls.
(Ingria 1990)'s claims that both feature neutrality, where a sign acts in sentence as though it simultaneously had multiple values for single feature, and the coordination of unlike categories, features two or more conjuncts differ from each other, pose fundamental problems unification-based theories grammar do not apply to constraint-based like HPSG.
 New types can be introduced into hierarchy appropriate any given directly represent neutralizations coordinations. In this manner,...
This study describes the clinical and electrodiagnostic (EDX) findings as well occupations hobbies in 613 patients diagnosed with carpal tunnel syndrome (CTS).Patients moderate, moderately severe, or severe CTS based on EDX criteria were included.The most common included workers offices, construction/maintenance, assembly lines. The occupation severity scores greatest garment workers, musicians, landscapers. Regardless of occupation, patient age duration significantly correlated ( P <...
Perioperative hypothermia (PH) is a preventable, pathological, and iatrogenic state that has been shown to result in increased surgical blood loss, site infections, hospital length of stay, patient discomfort. Maintenance normothermia recommended by multiple quality organizations; however, no group yet provides an ergonomic, evidence-based protocol reduce PH for pediatric neurosurgery patients. The authors' aim was evaluate the efficacy prevention population.
Linearization-based HPSG theories are widely used for analyzing languages with relatively free constituent order.This paper introduces the Generalized ID/LP (GIDLP) grammar format, which supports a direct encoding of such theories, and discusses key aspects parser that makes use dominance, precedence, linearization domain information explicitly encoded in this format.We show GIDLP grammars avoid explosion number rules required under traditional phrase structure analysis order.As result,...
Occult spinal dysraphism is a congenital failure of fusion the posterior vertebral arches with intact skin overlying defect. Lumbosacral cutaneous manifestations are associated variable risk occult dysraphism. Tethered cord syndrome type that puts abnormal traction on cord. This study analyzed neonates and infants who were referred to our pediatric urology practice had evidence lumbosacral manifestation physical examination.We reviewed presence in evaluated clinic at Institution over 6-year...
Testicular torsion poses a pediatric surgical emergency that necessitates rapid diagnosis and surgery to prevent testicular loss. We sought determine whether any particular findings on Doppler ultrasound (US) were predictive of viability in patients with torsion.We identified males between ages one 18 years who experienced over six-year period (January 1, 2015-December 31, 2020). All evaluated at our institution's department by urologist underwent scrotal US.Of the 140 torsion, 56 (40%) had...
Abstract Background uPA, its receptor uPAR, and inhibitors PAI‐1 PAI‐2 play key roles in membrane remodeling/invasion predicting response to chemotherapy. We identified novel relationships of these biomarkers with ER/PR that indicate clinical utility for assessing breast carcinoma outcomes. Methods Retrospective studies were performed de‐identified results (a) PAI‐1; (b) estrogen (ER) progestin (PR); (c) Relative expression 22 000 genes from microarray RNA LCM‐procured cancer cells was used...
Patients with intellectual/developmental disabilities are at risk of delayed diagnosis testicular torsion due to their inability effectively communicate symptoms. We identified males ages 1 18 years between January 1, 2015 and December 31, 2020, focusing on patients intellectual and/or developmental disabilities. Of the 140 torsion, 5 (3.6%) exhibited an verbalize testicular/groin/scrotal pain. The underwent more orchiectomies (5/5, 100%, P = .009) had a longer duration symptoms (median 48...
Background: Patients with recurrent glioblastoma (GBM) have limited treatment options. This study determined whether patients GBM treated initial radiation/temozolomide (TMZ) and reirradiation using fractionated stereotactic radiotherapy (FSRT) had improved outcomes. Materials methods: We identified 95 GBM, 50 of whom underwent FSRT at recurrence 45 who systemic only (control). The median total dose the time was 30 Gy in five fractions gadolinium-enhanced tumor only. Results: With a...
Background Early post-traumatic seizures (PTSs) may occur within seven days of traumatic brain injury (TBI). Although levetiracetam is frequently used for early PTS prophylaxis, it not recommended in current guidelines due to insufficient evidence. The objective this study was further evaluate dosing strategies prophylaxis. Methods A single-center retrospective cohort conducted utilizing the electronic medical record and a trauma database. primary outcome an incidence seizure TBI, defined as...