A5034137162- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Pituitary Gland Disorders and Treatments
- Immune Cell Function and Interaction
- Single-cell and spatial transcriptomics
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Brain Metastases and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Mathematical Biology Tumor Growth
- Cancer Research and Treatments
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- Adrenal and Paraganglionic Tumors
- EEG and Brain-Computer Interfaces
- Cancer Genomics and Diagnostics
- Neural dynamics and brain function
- Immune cells in cancer
- Virus-based gene therapy research
- Surgical Simulation and Training
- Neuroscience and Neural Engineering
- Adrenal Hormones and Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Head and Neck Surgical Oncology
Massachusetts General Hospital
2015-2025
Harvard University
2011-2024
University of California, San Diego
2018-2024
Neurological Surgery
2023
Fruit Research Institute
2020
Kagoshima University
2018
Kagoshima University Hospital
2018
Brigham and Women's Hospital
2015
Broad Institute
2015
Oncology Specialists
2015
We recently reported that BRAF V600E is the principal oncogenic driver of papillary craniopharyngioma, a highly morbid intracranial tumor commonly refractory to treatment. Here, we describe our treatment man age 39 years with multiply recurrent craniopharyngioma using dabrafenib (150mg, orally twice daily) and trametinib (2mg, daily). After 35 days treatment, volume was reduced by 85%. Mutations mediate resistance MAPK pathway inhibition were not detected in post-treatment sample whole exome...
This issue sees the launch of a new look and philosophy to publishing research in broad area mathematical modelling medicine.In its previous format, "Journal Theoretical Medicine" aimed provide forum for dissemination original emanating from collaborations between theoreticians experimentalists.While Journal has run successfully since 1997, it become apparent recent years that umbrella theoretical medicine expanded diversified incorporate not only areas traditional biology but also into such...
Papillary craniopharyngiomas (PCPs) are characterized by the presence of BRAF V600E mutations, which emerging as a useful guide for diagnosis and treatment decision making. The ongoing multicenter phase 2 Alliance A071601 trial is evaluating efficacy mitogen‐activated protein kinase (MEK) inhibitors patients with PCPs. With continued successful responses, it proposed that (and MEK) be evaluated neoadjuvant
Leptomeningeal disease (LMD) is a common complication from solid tumor malignancies with poor prognosis and limited treatment options. We present single arm Phase II study of 18 patients LMD receiving combined ipilimumab nivolumab until progression or unacceptable toxicity (NCT02939300). The primary end point overall survival at 3 months (OS3). Secondary points include toxicity, cumulative time-to-progression months, progression-free survival. A Simon two-stage design used to compare null...
Recent clinical trials have highlighted the limited efficacy of T cell-based immunotherapy in patients with glioblastoma (GBM). To better understand characteristics tumor-infiltrating lymphocytes (TIL) GBM, we performed cellular indexing transcriptomes and epitopes by sequencing single-cell RNA paired V(D)J sequencing, respectively, on TILs from two cohorts totaling 15 high-grade glioma, including GBM or astrocytoma, IDH-mutant, grade 4 (G4A). Analysis CD8+ TIL landscape reveals an...
Liquid biopsy offers a minimally invasive tool to diagnose and monitor the heterogeneous molecular landscape of tumors over time therapy. Detection TERT promoter mutations (C228T, C250T) in cfDNA has been successful for some systemic cancers but yet be demonstrated gliomas, despite high prevalence these glioma tissue (>60% all tumors).Here, we developed novel digital droplet PCR (ddPCR) assay that incorporates features improve sensitivity allows simultaneous detection longitudinal monitoring...
Surgical workflow analysis seeks to systematically break down operations into hierarchal components. It facilitates education, training, and understanding of surgical variations. There are known educational demands variations in practice endoscopic transsphenoidal approaches pituitary adenomas. Through an iterative consensus process, we generated a reflective contemporary practice.A mixed-methods process composed literature review Delphi surveys was carried out within the Pituitary Society....
Delays and risks associated with neurosurgical biopsies preclude timely diagnosis treatment of central nervous system (CNS) lymphoma other CNS neoplasms. We prospectively integrated targeted rapid genotyping cerebrospinal fluid (CSF) into the evaluation 70 patients lesions unknown cause. Participants underwent CSF-derived DNA using a quantitative polymerase chain reaction-based approach for parallel detection single-nucleotide variants in MYD88, TERT promoter, IDH1, IDH2, BRAF, H3F3A genes...
Recurrent malignant glioma carries a dismal prognosis, and novel therapies are needed. We examined the feasibility safety of vaccination with irradiated autologous cells mixed GM-K562 in patients undergoing craniotomy for recurrent glioma.We initiated phase I study examining 2 doses cells. Primary endpoints were safety. Feasibility was defined as ability 60% enrolled subjects to initiate vaccination. Dose-limiting toxicity assessed via 3+3 dose-escalation format, tumor 5 × 10(6) or 1 10(7)...
Despite ongoing advances in our understanding of local single-cellular and network-level activity neuronal populations the human brain, extraordinarily little is known about their "intermediate" microscale circuit dynamics. Here, we utilized ultra-high-density microelectrode arrays a rare opportunity to perform intracranial recordings across multiple cortical areas participants discover three distinct classes that are not locked natural brain rhythmic activity. The first included fast...
The limited radiation tolerance of the optic nerves and chiasm makes it a challenge to treat immediately adjacent lesions with radiosurgery. Staged or hypofractionated radiosurgery has virtue combining accuracy conformality normal tissue-sparing benefits fractionation. We describe consecutive series patients meningiomas pituitary adenomas abutting anterior visual pathways who were treated staged, image-guided radiosurgery.Thirty-four either (20 patients) (14 within 2 mm apparatus treated....
Abstract Purpose To determine the prevalence of insulin-like growth factor-1 (IGF-1) normalization with long-term multimodality therapy in a pituitary center and to assess changes over time. Methods Patients acromegaly (N = 409), ≥1 year data after surgery at least 2 subsequent clinic visits were included analysis 266). Biochemical data, clinical characteristics, therapeutic interventions reviewed retrospectively. Results At diagnosis, mean [standard deviation] age was 43.4 [14.3] years,...
Papillary craniopharyngiomas are characterized by BRAFV600E mutations. Targeted therapy can elicit a dramatic radiographic regression of these tumors. Therefore, prediction BRAF mutation status before definitive surgery could enable neoadjuvant treatment strategies.To establish preoperative criteria to identify patients with mutant craniopharyngioma.Sixty-four craniopharyngioma were included in this study. We determined targeted sequencing. After scoring interobserver variability between...
BackgroundMalignant gliomas are rapidly progressive brain tumors with high mortality. Fluorescence guided surgery (FGS) 5-aminolevulinic acid (5-ALA) provides fluorescent delineation of malignant tissue, which helps achieve maximum safe resection. 5-ALA-based fluorescence is due to preferential accumulation the fluorophore protoporphyrin-IX (PpIX) in glioma tissue. Additionally, cells release extracellular vesicles (EVs) carry biomarkers disease. Herein, we performed animal and human studies...