NFDI4DS | UHH-SEMS - Publication Details

Markus I. Anzaldua-Campos

ORCID: 0000-0003-4727-3404

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A5092707935

Research Areas

Cancer Immunotherapy and Biomarkers
CAR-T cell therapy research
Immune Cell Function and Interaction
Single-cell and spatial transcriptomics
T-cell and B-cell Immunology
Mathematical Biology Tumor Growth
Galectins and Cancer Biology
Nanoplatforms for cancer theranostics
Glioma Diagnosis and Treatment
Photoacoustic and Ultrasonic Imaging
Photodynamic Therapy Research Studies

Harvard University
2023-2024

Harvard University Press
2023-2024

Massachusetts General Hospital
2023-2024

Glioblastoma-Infiltrating CD8+ T Cells Are Predominantly a Clonally Expanded GZMK+ Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

Recent clinical trials have highlighted the limited efficacy of T cell-based immunotherapy in patients with glioblastoma (GBM). To better understand characteristics tumor-infiltrating lymphocytes (TIL) GBM, we performed cellular indexing transcriptomes and epitopes by sequencing single-cell RNA paired V(D)J sequencing, respectively, on TILs from two cohorts totaling 15 high-grade glioma, including GBM or astrocytoma, IDH-mutant, grade 4 (G4A). Analysis CD8+ TIL landscape reveals an...

10.1158/2159-8290.cd-23-0913 article EN Cancer Discovery 2024-02-27

Supplementary_Table_S4 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>Gene markers for Xenium in situ cell type identification.</p>

10.1158/2159-8290.25956905 preprint EN cc-by 2024-06-03

Supplementary_Fig_S11 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>Heatmap of top differentially expressed genes by CD8+ T cell states from cohorts 1 and 2.</p>

10.1158/2159-8290.25956959 preprint EN cc-by 2024-06-03

Supplementary_File_S4 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>scGSEA correlation values</p>

10.1158/2159-8290.25956917 preprint NL cc-by 2024-06-03

Supplementary_Fig_S4 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>Dot plot of select gene markers for cell type identification CD8+ T cells from cohort 1.</p>

10.1158/2159-8290.25956944 preprint EN cc-by 2024-06-03

Supplementary_Fig_S9 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>Comparison of CD8+ GZMK+ TIL from IDH-WT GBM and IDH-mut G4A samples.</p>

10.1158/2159-8290.25956929 preprint EN cc-by 2024-06-03

Supplementary_Table_S3 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>Antibody markers and respective clone numbers.</p>

10.1158/2159-8290.25956908 preprint EN cc-by 2024-06-03

Supplementary_Table_S1 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>Patient demographics and sample characteristics.</p>

10.1158/2159-8290.25956914 preprint EN cc-by 2024-06-03

Supplementary_Fig_S10 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>Comparison of TIL from primary and recurrent GBM samples.</p>

10.1158/2159-8290.25956962 preprint EN cc-by 2024-06-03

Supplementary_Fig_S12 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>Harmony integration of TIL from many cancer types.</p>

10.1158/2159-8290.25956956 preprint EN cc-by 2024-06-03

Supplementary_Fig_S8 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>Inhibitory score analysis of the integrated T cells from cohorts 1 and 2.</p>

10.1158/2159-8290.25956932 preprint EN cc-by 2024-06-03

Supplementary_Table_S2 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>Gene markers for cell type identification and gene signatures.</p>

10.1158/2159-8290.25956911 preprint EN cc-by 2024-06-03

Supplementary_Fig_S1 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>MAIT clonotype occurrence in T cells from cohort 1.</p>

10.1158/2159-8290.25956965 preprint EN cc-by 2024-06-03

Supplementary_Fig_S3 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>Analysis of RNA Tirosh exhaustion and inhibitory scores expressed by T cells from cohort 1.</p>

10.1158/2159-8290.25956947 preprint EN cc-by 2024-06-03

Supplementary_File_S2 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>Neighborhood enrichment raw z scores</p>

10.1158/2159-8290.25956923 preprint NL cc-by 2024-06-03

Supplementary_File_S1 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>DEGs of various T cell populations</p>

10.1158/2159-8290.25956926 preprint EN cc-by 2024-06-03

Supplementary_Fig_S7 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>Analysis of GBM tumor Xenium spatial sample.</p>

10.1158/2159-8290.25956935 preprint EN cc-by 2024-06-03

Supplementary_Fig_S13 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>TCR landscape of ex vivo expanded TIL does not recapitulate the initial TCR landscape.</p>

10.1158/2159-8290.25956953.v1 preprint EN cc-by 2024-06-03

Supplementary_File_S1 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>DEGs of various T cell populations</p>

10.1158/2159-8290.25956926.v1 preprint EN cc-by 2024-06-03

Supplementary_Fig_S9 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>Comparison of CD8+ GZMK+ TIL from IDH-WT GBM and IDH-mut G4A samples.</p>

10.1158/2159-8290.25956929.v1 preprint EN cc-by 2024-06-03

Supplementary_Table_S3 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>Antibody markers and respective clone numbers.</p>

10.1158/2159-8290.25956908.v1 preprint EN cc-by 2024-06-03

Supplementary_Fig_S4 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>Dot plot of select gene markers for cell type identification CD8+ T cells from cohort 1.</p>

10.1158/2159-8290.25956944.v1 preprint EN cc-by 2024-06-03

Supplementary_Table_S4 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>Gene markers for Xenium in situ cell type identification.</p>

10.1158/2159-8290.25956905.v1 preprint EN cc-by 2024-06-03

Supplementary_File_S3 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>Supplementary Fig. S10 genes and associated GO BPs</p>

10.1158/2159-8290.25956920.v1 preprint EN cc-by 2024-06-03

Supplementary_Fig_S12 from Glioblastoma-Infiltrating <i>CD8</i><sup>+</sup> T Cells Are Predominantly a Clonally Expanded <i>GZMK</i><sup>+</sup> Effector Population

OPENALEX - Publications

Anthony Z. Wang Bryce L. Mashimo Maximilian O. Schaettler Ngima D. Sherpa Lydia A. Leavitt and 16 more

<p>Harmony integration of TIL from many cancer types.</p>

10.1158/2159-8290.25956956.v1 preprint EN cc-by 2024-06-03

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