A5061582826- Thyroid Disorders and Treatments
- Neonatal Health and Biochemistry
- Thyroid Cancer Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Neuroscience of respiration and sleep
- Heavy Metal Exposure and Toxicity
- Birth, Development, and Health
- Folate and B Vitamins Research
- Pharmacological Effects and Toxicity Studies
- Effects and risks of endocrine disrupting chemicals
- Ion channel regulation and function
- Hormonal and reproductive studies
- Pregnancy and preeclampsia studies
- Mercury impact and mitigation studies
- Renal Transplantation Outcomes and Treatments
- Vitamin D Research Studies
- Prenatal Substance Exposure Effects
- Pharmaceutical studies and practices
- Trace Elements in Health
- Estrogen and related hormone effects
- Chemical Analysis and Environmental Impact
- Congenital Anomalies and Fetal Surgery
- Acute Lymphoblastic Leukemia research
- Pregnancy and Medication Impact
- Pharmacogenetics and Drug Metabolism
Georgetown University Medical Center
2007-2022
Georgetown University
2009-2022
American Thyroid Association
2011
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2010
Hospital Universitario Virgen de la Arrixaca
2010
Institute of Molecular Biology and Biophysics
2009
Children's National
2003-2009
George Washington University
2003-2009
Individual Differences
2005-2009
National Institutes of Health
2006-2009
Thyroid disease in pregnancy is a common clinical problem. Since the guidelines for management of these disorders by American Association (ATA) were first published 2011, significant and scientific advances have occurred field. The aim to inform clinicians, patients, researchers, health policy makers on evidence relating diagnosis thyroid women during pregnancy, preconception, postpartum period.The specific questions addressed based prior versions guidelines, stakeholder input, input task...
Objectives: To describe the interrelationships of thyroid functions based on trimester-specific concentrations in healthy, iodine-sufficient pregnant women across trimesters, and postpartum. Methods: Circulating total 3,5,3'- triidothyronine (T3) thyroxine (T4) were determined simultaneously using liquid chromatography tandem mass-spectrometry (LC/MS/MS). Free (FT4), thyroid-stimulating hormone (TSH), thyroglobulin (Tg) measured immunoassay techniques. Linear mixed effects models...
Objective: Pregnancy is a time of rapidly changing demands on the thyroid axis, and knowledge hormone levels, especially during first trimester, important for ensuring maternal fetal health. The assays currently in use become more inaccurate at extremes binding protein concentrations when heterophilic antibodies are present. characterized by both these conditions, making accurate determination free levels conventional direct analog immunoassay methods difficult. objective this study was to...
Increasing scientific evidence suggests that exposure to phthalates during pregnancy may be associated with an elevated risk of adverse reproductive outcomes such as preterm birth. Maternal endocrine disruption across one pathway mediating some these relationships. We investigated whether urinary phthalate metabolites were maternal serum thyroid (free thyroxine [FT4], free triiodothyronine [FT3], and thyroid-stimulating hormone [TSH]), sex (estradiol, progesterone, hormone-binding globulin...
Abstract Background: Accurate measurement of free thyroid hormones is important for managing disorders. Ultrafiltration liquid chromatography tandem mass spectrometry (LC-MS/MS) can reliably measure the concentrations small molecules, including hormones. Our study was designed to compare hormone measurements performed with immunoassay and LC-MS/MS. Methods: We studied performance LC-MS/MS in 4 different populations comprising pediatric patients, euthyroid adults, healthy nonpregnant pregnant...