A5004229802- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- High Entropy Alloys Studies
- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Cancer Research and Treatments
- Immune Cell Function and Interaction
- High-Temperature Coating Behaviors
- Nanocomposite Films for Food Packaging
- Corrosion Behavior and Inhibition
- Engineering Structural Analysis Methods
- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Biochemical Acid Research Studies
- Pluripotent Stem Cells Research
- Pancreatic function and diabetes
- Ubiquitin and proteasome pathways
- Tissue Engineering and Regenerative Medicine
- Mechanical Engineering and Vibrations Research
- Genomics, phytochemicals, and oxidative stress
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Bioinformatics and Genomic Networks
- Advanced Cellulose Research Studies
- Cell Image Analysis Techniques
Allen Institute
2023-2024
Massachusetts Institute of Technology
2023-2024
Koch Institute for Integrative Cancer Research At MIT
2023
Rice University
2020-2022
Abstract Hunger and chronic undernourishment impact over 800 million people, which translates to ≈10.7% of the world's population. While countries are increasingly making efforts reduce poverty hunger by pursuing sustainable energy agricultural practices, a third food produced around globe still is wasted never consumed. Reducing shortages vital in this effort often addressed development genetically modified produce or chemical additives inedible coatings, create additional health...
Proinflammatory cytokines have been approved by the Food and Drug Administration for treatment of metastatic melanoma renal carcinoma. However, effective cytokine therapy requires high-dose infusions that can result in antidrug antibodies and/or systemic side effects limit long-term benefits. To overcome these limitations, we developed a clinically translatable delivery platform composed polymer-encapsulated human ARPE-19 (RPE) cells produce natural cytokines. Tumor-adjacent administration...
Despite decades of research, metallic corrosion remains a long-standing challenge in many engineering applications. Specifically, designing material that can resist both abiotic as well biotic environments elusive. Here lightweight sulfur-selenium (S-Se) alloy is designed with high stiffness and ductility serve an excellent corrosion-resistant coating protection efficiency ≈99.9% for steel wide range diverse environments. S-Se coated mild shows rate 6-7 orders magnitude lower than bare metal...
Intratumoral heterogeneity (ITH) and subclonal antigen expression blunt antitumor immunity are associated with poor responses to immune-checkpoint blockade immunotherapy (ICB) in patients cancer. The underlying mechanisms however thus far remained elusive, preventing the design of novel treatment approaches for high ITH tumors.
In article 1908291, Muhammad M. Rahman, Pulickel Ajayan, and co-workers present a conformal bio-nanocomposite coating based on cellulose nanocrystals poly(albumen) that increases the shelf-life of fresh produce by retarding ripening, dehydration, microbial attack. The is edible, easily washable, made from readily available inexpensive materials, which makes it promising solution to combat food wastage.
<h3>Background</h3> Glioblastoma (GBM) is an aggressive form of adult brain cancer with poor prognosis. Checkpoint inhibitors and other immunotherapies have shown limited efficacy in GBM, largely due to the immunosuppressive tumor microenvironment (TME). The GBM TME highly infiltrated associated macrophages (TAMs) that promote aggression impede cytotoxic T cell activities. Immunopeptidomics, profiling MHC-I peptides presented on surfaces using liquid chromatograph tandem mass spectrometry...
Abstract Coordination of adaptive metabolism through cellular signaling networks and metabolic response is essential for balanced flow energy homeostasis. Post-translational modifications such as phosphorylation offer a rapid, efficient, dynamic mechanism to regulate networks. Although numerous sites have been identified on enzymes, much remains unknown about their contribution enzyme function systemic metabolism. In this study, we stratify enzymes based location with respect functional...
Abstract Dysregulation of intracellular signaling networks underpins cancer. However, a systems-level elucidation how within distinct cell subpopulations drive cancer progression in vivo has been unattainable due to technical limitations. We developed INSIGHT (INvestigating SIGnaling network specific subpopulation Heterogeneous Tissue), new platform technology combining fluorescence-activated sorting with ultra-sensitive mass spectrometry enable phosphoproteomic characterization rare and...
This study focuses on the rivet early fatigue characteristics in a deep-groove ball bearing cage for transmission system turboprop engine. Nonlinear dynamic differential equations with two-piece were developed. The stress was used to identify failure mechanism of rivets. investigation revealed that by delivering an optimal preload causes two halves have less misalignment and lower stress. fit relationship between bore has significant influence Excessive clearance increases head rivet, while...
<h3>Background</h3> Intra-tumoral heterogeneity (ITH) and sub-clonal neoantigen presentation can impair anti-tumor T cell responses are closely linked to poor efficacy of checkpoint blockade immunotherapy. Yet, an understanding the mechanisms by which ITH facilitates immune evasion remains elusive, impeding rational design neoantigen-based immunotherapies, including cancer vaccines, for tumors. <h3>Methods</h3> We used lentiviral transduction express single or multiple neoantigens in a...
Despite decades of research, metallic corrosion remains a long-standing challenge in many engineering applications. Specifically, designing material that can resist both abiotic as well biotic environments elusive. Here we design lightweight sulfur-selenium (S-Se) alloy with high stiffness and ductility serve universal corrosion-resistant coating protection efficiency ~99.9% for steel wide range diverse environments. S-Se coated mild shows rate is 6-7 orders magnitude lower than bare metal...
Abstract Recombinant IL-2 has been approved for the treatment of melanoma and renal cancer. However, therapy is limited by its short half-life in circulation associated toxicities that emerge as a result high systemic exposure. To overcome these limitations, we developed localized cytokine LOCOcyteTM platform composed allogeneic engineered cells which produce potent immune effector molecules local delivery with temporal regulation activity. Administration AVB-001 mice non-human primates...
Background Pro-inflammatory cytokines have been approved by the FDA for treatment of metastatic melanoma and renal carcinoma. 1 2 However, effective cytokine therapy is limited its short half-life in circulation severe adverse effects associated with high systemic exposure. 3 To overcome these limitations, we developed a clinically translatable localized delivery platform composed polymer encapsulated epithelial cells that produce natural (IL2, IL7, IL10, or IL12) temporal regulation....