A5102743313- Animal Nutrition and Physiology
- Growth Hormone and Insulin-like Growth Factors
- Mitochondrial Function and Pathology
- Hypothalamic control of reproductive hormones
- Diabetes Management and Research
- Biochemical Acid Research Studies
- Diabetes and associated disorders
- Plant Reproductive Biology
- Pancreatic function and diabetes
- Genomics, phytochemicals, and oxidative stress
- Estrogen and related hormone effects
Massachusetts Institute of Technology
2024
Harvard Stem Cell Institute
2024
Indian Veterinary Research Institute
2011
Abstract Islet transplantation for treatment of diabetes is limited by availability donor islets and requirements immunosuppression. Stem cell-derived might circumvent these issues. SC-islets effectively control glucose metabolism post transplantation, but do not yet achieve full function in vitro with current published differentiation protocols. We aimed to identify markers mature subpopulations SC-β cells studying transcriptional changes associated vivo maturation using RNA-seq...
Abstract Coordination of adaptive metabolism through cellular signaling networks and metabolic response is essential for balanced flow energy homeostasis. Post-translational modifications such as phosphorylation offer a rapid, efficient, dynamic mechanism to regulate networks. Although numerous sites have been identified on enzymes, much remains unknown about their contribution enzyme function systemic metabolism. In this study, we stratify enzymes based location with respect functional...